李艳
邮箱：yan.li@ynu.edu.cn
职称：研究员，博士生导师
地址：云南省昆明市翠湖北路2号





受教育经历及工作经历：
1991.09-1995.07，山东大学，生物学，学士
1995.09-1998.07，山东大学，细胞生物学，硕士
1998.09-2001.12，山东大学/德国癌症研究中心，分子发育生物学，联合培养博士
2002.01-2003.11，德国癌症研究中心，博士后
2003.12-2007.12，美国辛辛那提儿童医院医学中心，research fellow
2008.01-2021.06，中国科学院昆明植物研究所，研究员
2021.06-至今,云南大学自然资源药物化学教育部重点实验室，研究员

荣誉及奖励
云南省“高端科技人才引进计划，2009年度
中国科学院“****”，2010年度
云南省首批“百名海外高层次人才引进计划”,2011年度
云南省政府特殊津贴人才，2014年度

研究领域
依托云南省及西南地区丰富的生物资源和中医药资源，通过生物和化学学科交叉，围绕肿瘤发生相关信号通路，肿瘤干细胞，肿瘤免疫等，开展肿瘤新靶点，新机制，新药物分子的药理学和化学生物学创新研究。研究成果发表于Nature, Genes & Development, Oncogene, Cell Chemical Biology, Journal of Biological Chemistry, Biochemical Pharmacology, Organic Letters 等重要期刊，申请授权专利多项，主持 973 课题、国家基金重点项目（云南联合）及面上基金等项目。

代表性论文
1. Zhang SH, Ju XM, Yang QH, ZhuYY, Fan DM, Su GF, Kong LM, Li Y*. USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide. Biochem. Biophys. Res. Commun, 2021, 562:21-28
2. Li X, Kong LM, Yang QH, Duan AZ, Ju XM, Cai BC, Chen L, An T*, Li Y*. Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth. J. Biol. Chem, 2020, 295: 3576-3589
3. Ma PC#, An T#, Zhu L, Zhang LL, Wang HS, Ren BY, Sun B, Zhou X, Li Y*, Mao BY*. RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling. Development, 2020, 147, dev188078
4. Chen L, Fan DM, Tang JW, An T, Li X, Kong LM*, Puno PT*, Li Y*. Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization. Biochem. Biophys. Res. Commun, 2020, 525:303-307
5. Zhu HF#, Wang B#, Kong LM, An T, Li GT, Zhou HY, Gong L, Zhao ZX, Gong YX, Sun HD, Puno PT*, Li Y*. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin. Cell. Chem. Biol, 2019, 26(8):1122-1132
6. Zhou HY#, Yu CL#, Kong LM#, Xu XL, Yan JM, Li YC, An T, Gong L, Gong YX, Zhu HF, Zhang HB*, Yang XD*, Li Y*. B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells. Oncogene, 2019, 38:3371-3386
7. Tang JW#, Kong LM#, Zu WY, Hu K, Su XZ, Li XN, Yan BC, Wang WG, Sun HD, Li Y*, Puno PT*. Isopenicins A–C: Two Types of Novel Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. Org. Lett, 2019, 21:771-775
8. Wang LL#, Kong LM#, Liu H, Zhang YQ, Zhang L, Liu XY, Yuan F, Li Y*, Zuo ZL*. Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo. Eur. J. Med. Chem, 2019, 182:111665
9. An T, Gong YX, Li X, Kong LM, Ma PC, Gong L, Zhu HF, Yu CL, Liu JM, Zhou HY, Mao BY, Li Y*. USP7 inhibitor P5091 inhibits Wnt signaling and coloreal tumor growth. Biochem. Pharmacol, 2017, 131(1):29-39
10. Yu CL, Gong YX, Zhou HY, Wang M, Kong LM, Liu JM, An T, Zhu HF, Li Y*. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthpic humanbreast cancer model. Cell Death Dis, 2017, 8 (2): e2582.
11. Shao LD#, Su J#, Ye BX#, Liu JX#, Zuo ZL, Li Y, Wang YY*, Xia CF*, Zhao QS*. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors. J. Med. Chem., 2017, 60 (21): 9053–9066 60(21).
12. Zhou HY#, Shang CW#, Wang M, Shen T, Kong LM, Yu CL, Ye ZN, Luo Y, Liu L, Li Y*, Huang SL*. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Biochem. Pharmacol, 2016, 16:39-50
13. Wang M, Zhou AK, An T, Kong LM, Yu CL, Liu JM, Xia CF*, Zhou HY*, Li Y*. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res, 2016, 35:41
14. Kong LM, Mao BY, Zhu HJ*, Li Y*. Novel β-carbolines inhibit Wnt/β-catenin signaling. Cell Death Dis, 2015, 6, e1983