赵立兴

邮箱：lixingzhao@ynu.edu.cn
职称：研究员
地址：云南昆明呈贡区大学城东外环南路云南大学化学楼5楼




个人简历
教育经历
1997.8 – 2000.6，理学博士，微生物学，中国科学院应用生态研究所
1994.9 – 1997.7，理学硕士，植物学，中国林业科学研究院
1990.9 – 1994.7，农学学士，林学，安徽农业大学林学系

工作经历
2018.11 – 至今，研究员，云南大学，教育部自然资源药物化学重点实验室、云南省微生物研究所
2012.11 – 2018.10，副研究员，云南大学，云南省微生物研究所
2007.05 – 2012.10，助理研究员，云南大学，云南省微生物研究所
2007.08 – 2008.07，访问****，美国University of Wisconsin-Madison，药学院
2000.06 – 2007.05，工程师，昆明制药集团，药物研究院

研究领域
1） 药用微生物资源收集及筛选：微生物药物在临床和农业生产中都占据着重要的位置。从微生物资源中发现新型的微生物药物是解决耐药性和开发新药的一个重要途径。
2） 微生物天然药物研究：微生物是临床使用的抗感染、抗肿瘤等药物的重要来源，在农畜牧业生产中也广泛；从各种环境下收集到的活性菌株中发现微生物天然药物分子或先导化合物，进行微生物天然药物的研究与开发。
代表性论文
1. Wang, Y.-L.; Hu, B.-Y.; Qian, M.-A.; Wang, Z.-H.; Zou, J.-M.; Sang, X.-Y.; Li, L.; Luo, X.-D.^*; Zhao, L.-X.^* Koninginin W, a new polyketide from the endophytic fungus Trichoderma koningiopsis YIM PH30002. Chemistry & Biodiversity, 2021, doi: 10.1002/cbdv.
2. Sang, X.-Y.; Wang, Z.-J.; Yang, Y.-B.; Wang, Y.-L.; Xiang, M.-L.; Zhou, D.-Y.; Luo, X.-D. ; Zhao, L.-X.^* Antimicrobial natural products produced by soil-derived fungus Penicillium cremeogriseum W1-1. Indian Journal of Microbiology, 2021, doi: 10.1007/s12088-021-00957-z
3. Hu, B.-Y.; Zhao, Y.-L.; Xiong, D.-S.; He, Y.-J.; Zhou, Z.-S.; Zhu, P.-F.; Wang, Z.-J.; Wang, Y.-L.; Zhao, L.-X.^*; Luo, X.-D.^* Potent antihyperuricemic triterpenoids based on two unprecedented scaffolds from the leaves of Alstonia scholaris. Organic Letter, 2021, 23:4158-4162
4. Xiong, D.-S.; Yang, Y.-B.; Hu, B.-Y.; Miao, C.-P.; Wang, Y.-L.; Zou, J.-M.; Li, L.; Li, Y.Q.; Luo, X.-D.^*; Zhao, L.-X.^* Myrothins A-F from endophytic fungus Myrothecium sp. BS-31 harbored in Panax notoginseng. Chemistry & Biodiversity, 2021, doi: 10.1002/CBDV.
5. Hu, J.-Y.; Li, L.; Peng, G.; Li, Y.-Q.; Xu, L.-H.; Guan, H.-L.; Zhao, L.-X.^*; Miao, C.-P.^* Nocardia panacis sp. nov., a novel actinomycete with antiphytopathogen activity isolated from the rhizosphere of Panax notoginseng. Antoni van Leeuwenhoek, 2020,113:165-174
6. Peng, G.; Xiong, D.-S.; Li, L.-C.; Hu, J.-Y.; Bao, S.; Chen, Y.-W.; Li, Y.-Q.; Xu, L.-H.; Miao, C.-P.; Zhao, L.-X.^* Amycolatopsis panacis sp. nov., isolated from Panax notoginseng rhizospheric soil. International Journal of Systematic and Evolutionary Microbiology, 2019, 69:567-571
7. Luo, N.; Yang, Y.-B.; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Xu, L.-H.; Ding, Z.-T.; Zhao, L.-X.^* The streptazolin- and obscurolide-type metabolites from soil-derived Streptomyce alboniger YIM20533 and the mechanism of influence of γ-butyrolactone on the growth of Streptomyces by their non-enzymatic reaction biosynthesis. RSC Advances, 2018, 8:35042-35049
8. Wang, Q.; Yang, Y.-B.; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Liu, S.-X.; Luo, N.; Ding, Z.-T.; Zhao, L.-X.^* Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711. Phytochemistry, 2018,145(1):146-152
9. Zheng, Y.-K.; Miao, C.-P.; Chen, H.-H.; Huang, F.-F.; Xia, Y.-M.; Chen, Y.-W.; Zhao L.-X.^*. Endophytic fungi harbored in Panax notoginseng - diversity and potential as biological control agents against host plant pathogens of root-rot disease. Journal of Ginseng Research, 2017, 41:353-360
10. Chen, J.-L.; Sun, S.-Z.; Miao, C.-P.; Wu, K.; Chen Y.-W.; Xu, L.-H.; Guan, H.-L; Zhao L.-X.^* Endophytic Trichoderma gamsii YIM PH30019: a promising biocontrol agent with hyperosmolar, mycoparasitism, and antagonistic activities of induced volatile organic compounds on root-rot pathogenic fungi of Panax notoginseng. Journal of Ginseng Research. 2016, 40:315-324
11. Miao, C.-P.; Mi, Q.-L.; Qiao, X.-G.; Zheng, Y.-K.; Chen, Y.-W.; Xu, L.-H.; Guan H.-L.; Zhao L.-X.^* Rhizospheric fungi of Panax notoginseng: diversity and antagonism to host phytopathogens. Journal of Ginseng Research. 2016, 40:127-134
12. Fan, Z.-Y.; Miao, C.-P.; Qiao, X.-G.; Zheng, Y.-K.; Chen, H.-H.; Chen, Y.-W.; Xu, L.-H.; Zhao L.-X.;^* Guan, H.-L. Diversity, distribution, and antagonistic activities of rhizobacteria of Panax notoginseng. Journal of Ginseng Research. 2016, 40:97-104
13. Cao, P.; Yang, J.; Miao, C.-P.; Yan, Y.J.; Ma, Y.-T.; Li, X.-N.; Zhao L.-X.;^* Huang, S.-X. New duclauxamide from Penicillium manginii YIM PH30375 and structure revision of the duclauxin family. Organic Letters. 2015, 17:1146-1149
14. Liu, K.; Yang, Y.-B.; Miao, C.-P.; Zheng, Y.-K.; Chen, J.-L.; Chen, Y.-W.; Xu, L.-H.; Guan, H.-L.; Ding, Z.-T.; Zhao L.-X.^* Koningiopsins A-H, polyketides with synergistic antifungal activities from the endophytic fungus Trichoderma koningiopsis. Planta Medica. 2016, 82:371-376
15. Xiong, Z.-J.; Miao, C.-P.; Zheng, Y.-K.; Liu, K.; Li, W.-J.; Liu, W.-H.; Xu, L.-H.; Zhao L.-X.^* Stackebrandtia endophytica sp. nov., an actinobacterium isolated from Tripterygium wilfordii. International Journal of Systematic and Evolutionary Microbiology. 2015, 65:1709-1713
16. Zhao, L.-X.; Xu, L.-H.; Jiang, C.-L. Methods for the study of endophytic microorganisms from traditional Chinese medicine plants. Methods in Enzymology. 2012, 517:3-21
17. Zhao, L.-X.; Huang, S.-X.; Tang, S.-K.; Jiang, C.-L.; Duan, Y.; Beutler, J.-A.; Henrich, C.-J.; McMahon, J.-B., Schmid, T.; Blees, J.-S.; Colburn, N.-H.; Rajski, S.-R.; Shen, B. Actinopolysporins A-C and Tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Journal of Natural Products. 2011, 74:1990-1995

执教课程
《微生物学概论》