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云南大学自然资源药物化学重点实验室导师教师师资介绍简介-熊文勇研究员

本站小编 Free考研考试/2021-11-06




熊文勇
邮箱:xwy@ynu.edu.cn
职称:研究员,博士生导师
地址:云南省昆明市翠湖北路2号云南大学化学楼




教育及工作经历
1995-1999,陕西师范大学,学士
1999-2004,中国科学院昆明动物研究所,博士(导师:徐林 研究员)
2004-2007,美国南加州大学医学院 (University of Southern California) ,博士后
2007-2011,美国康乃尔大学医学院(Cornell University),博士后
2011-2020,中国科学院昆明植物研究所,研究员
2019-今,云南大学,研究员
荣誉及奖励
1999,陕西省优秀毕业生
2012,中国科学院****
2013,云南省高端科技人才
科研领域描述
利用分子生物学及生物化学、细胞生物学、生物物理及药理学等多种研究手段开展治疗2型糖尿病等代谢性疾病的药物发现与药理研究工作。围绕脂肪细胞分化的调控、胰岛素受体信号通路、GLUT4、SGLT2、胰岛素分泌、非酒精性脂肪肝等开展研究工作。近几年在GLUT4和GLUT1的研究中取得一系列重要进展并逐步形成系统和自身特色;发现一批新颖活性的天然产物,开展了药用功能及药理研究,以通讯作者在Journal of Cell Science (2017)、Proc. Natl. Acad. Sci. U. S. A. (2018)、Nanoscale Horizons (2018)、Journal of Biological Chemistry (2019)等国际著名期刊发表研究论文30多篇,申请并获得专利多项。先后获得国家自然科学基金委、云南省科技厅以及国家重点研发计划项目支持。
代表性论文:
1. Fang Wang#, Xiaoyan Yang#, Yanting Lu, Zhenghui Li, Yuhui Xu, Jing Hu, Jikai Liu* and Wenyong Xiong*. The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. Journal of Biological Chemistry. 2019, 294(27), 10415-10427.
2. Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong*, Jing Gao,* Hongda Wang*. Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging. Proceedings of the National Academy of Sciences of the United States of America. 2018, 115 (27), 7033-7038.
3. Yangang Pan#, Yuebin Zhang#, Pianchou Gongpan#, Bin Wang, Bingqian Xu, Yuping Shan*, Wenyong Xiong*, Guohui Li* and Hongda Wang*. Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations. Nanoscale Horizons. 2018, 3(5), 517-524.
4. Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu*, and Wenyong Xiong*. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. Journal of Natural Products. 2017, 80, 2319?2327.
5. Lan Gao, Junling Chen, Jing Gao, Hongda Wang*, Wenyong Xiong*. Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance. Journal of Cell Science. 2017, 130, 396-405.
6. Qinghua Kong#, Lan Gao#, Yanfen Niu, Pianchou Gongpan, Yuhui Xu, Yan Li*, Wenyong Xiong*. RACK1 is required for adipogenesis. American Journal of Physiology-Cell Physiology. 2016, 311(5), C831-C836.
7. Pianchou Gongpan, Yanting Lu, Fang Wang, Yuhui Xu & Wenyong Xiong*. AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21. Cell Cycle. 2016, 15(13), 1733-41.

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