E-mail: tant@lpbr.cn






一、受教育及工作经历 Education and Academic Positions



2000年―2004年， 兰州大学生命科学学院，生物科学学士学位。
2004年―2010年， 中国科学院昆明动物研究所，动物学专业，干细胞生物学研究方向获理学博士学位
2010年4月—2012年5月，中国科学院昆明动物研究所，助理研究员
2012年6月—2014年9月，云南中科灵长类生物医学重点实验室，副研究员
2014年10月—，昆明理工大学灵长类转化医学研究中心，副教授
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2000.09-2004.06: School of Life Sciences, Lanzhou University, B. S. in Biological Science
2004.09-2010.02: Kunming Institute of Zoology, Chinese Academy of Sciences, Ph. D. in Animal Science.
2010.4-2012.9: Assistant professor, Kunming Institute of Zoology, Chinese Academy of Sciences.
2014.10-Now: Associate professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology



二、主要研究方向 Research interests



胚胎干细胞自我更新机制；
灵长类早起胚胎发育；
干细胞及胚胎发育表观遗传学；
Primates pre- and post-implantation development.
Self-organization of primates pluripotency stem cells.
primates primordial germ cell, spermatogenesis.




三、科研领域描述



长期从事直从事干细胞及表观遗传学其相关工作，并成功从兔胚胎干细胞中诱导分化并建立滋养层干细胞系。现从事干细胞自我更新及定向分化中的表观遗传学调控机理，同时开展早期胚胎发育表观遗传学研究。



四、承担科研项目情况 Research funding



国家自然科学基金青年基金项目，**、RhoGDI在兔滋养层干细胞自我更新及分化中的作用及机理、2012/01-2014/12、 主持。
国家自然科学基金面上项目，**、DNA甲基化与早期胚胎发育的相关性研究、2014/01-2014/12、主持。
国家自然科学基金地区基金，**、运用正反向遗传学手段在猕猴单倍体胚胎干细胞中开展灵长类胚胎干细胞自我更新机制的研究、2015/01-2018/12、主持。
973, 帕金森氏病干细胞治疗的研究 2012/1-2016/8、研究骨干。
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2019-2024: “Study non-human primates peri-and post-implantation embryonesis”, Science and Technology Planning Project of Yunnan Province, 2,000,000, PI.
2019-2024: Yunan Ten Thousand Talents Plan Young & Elite Talents Projects, 500,000.
2018-2021: " Using embryo in vitro culture system and single cell transcriptome to study cynomolgus monkey post-implantation development and lineage determination", National Natural Science Foundation of China, 340,000, PI.
2017-2019: “Obtaining functional gametes from primates pluripotency stem cells", Science and Technology Planning Project of Yunnan Province, 1,200,000, PI.
2017-2020: “Study of PGC specification of non-human primates ", Science and Technology Planning Project of Yunnan Province, 5000,000, PI.



五、代表性论文和专著 Publications



Yuyu Niu*,Nianqin Sun,Chang Li,Ying Lei,Zhihao Huang,Jun Wu,Chenyang Si,Xi Dai,Chuanyu Liu,Longqi Liu,Su Feng,Yu Kang,Wei Si,Hong Wang,E. Zhang,Lu Zhao,Ziwei Li,Xi Luo,Guizhong Cui,Guangdun Peng,Juan Carlos Izpisúa Belmonte*,Weizhi Ji*,Tao Tan*. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science. 366(6467),[IF:41.037]
Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells.Hanlin Lu 1, Zhimei Yuan, Tao Tan, Junwen Wang, Juyong Zhang, Hui-Juan Luo, Yudong Xia, Weizhi Ji, Fei Gao*. Epigenomics. 2015 Feb;7(1):47-56. doi: 10.2217/epi.14.76.
miRNA signature in mouse spermatogonial stem cells revealed by high-throughput sequencing.Tao Tan, Yanfeng Zhang, Weizhi Ji*, Ping Zheng*. Biomed Res Int. 2014;2014:154251. doi: 10.1155/2014/154251.
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.Tao Tan, Bin Lu, Jing Zhang, Yuyu Niu, Wei Si, Qiang Wei, Weizhi Ji*. Stem Cells Dev. 2014 Apr 15;23(8):813-22. doi: 10.1089/scd.2013.0280.
Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and in-vitro-matured oocytes.Yong Fan, Hong-Cui Zhao, Jianqiao Liu, Tao Tan, Ting Ding, Rong Li, Yue Zhao, Jie Yan, Xiaofang Sun, Yang Yu, Jie Qiao.Sci Rep. 2015 Feb 3;5:8192. doi: 10.1038/srep08192.
Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji*. PLoS One. 2011 Feb 17;6(2):e17124. doi: 10.1371/journal.pone.**.
TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.Hailiang Liu #, Yongchang Chen #, Yuyu Niu #, Kunshan Zhang #, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou, Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li*, Yi Eve Sun*, Weizhi Ji*. Cell Stem Cell. 2014 Mar 6;14(3):323-8. doi: 10.1016/j.stem.2014.01.018
Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiaoyang Zhao, Wei Si, Wei Li, Andy Peng Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuomin Zhou, Tianqing Li, Tao Tan, Xiuqiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang*, Weizhi Ji*, Jiahao Sha*. Cell. 2014 Feb 13;156(4):836-43. doi: 10.1016/j.cell.2014.01.027.
Derivation of rhesus monkey parthenogenetic embryonic stem cells and its microRNA signature.Qiang Wei, Zhenghua Sun, Xiechao He, Tao Tan, Bin Lu, Xiangyu Guo, Bing Su, Weizhi Ji*. PLoS One. 2011;6(9):e25052. doi: 10.1371/journal.pone.**.
Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector.Yuyu Niu, Yang Yu, Agnieszka Bernat, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Lv, Tao Tan, Qiang Wei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, Pierre Savatier, Kang Zhang, Qi Zhou*, Weizhi Ji*. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17663-7. doi: 10.1073/pnas..
Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm.Wei Si, Yongqing Lu, Xiechao He, Shaohui Ji, Yuyu Niu, Tao Tan, Weizhi Ji*. Theriogenology. 2010 Nov;74(8):1431-8. doi: 10.1016/j.theriogenology.
Netrin-1 signaling mediates NO-induced glial precursor migration and accumulation.Hongwei Chen, Qiang Wei, Jing Zhang, Chuangkun Xu, Tao Tan, Weizhi Ji*. Cell Res. 2010 Feb;20(2):238-41. doi: 10.1038/cr.2010.7.



六、研究人员








郭荣荣

博士，讲师

主要研究方向：
早期胚胎发育
体外非人灵长类干细胞的配子发生