袁春华^1,2, 王江¹, 邓斌¹
AuthorsHTML:袁春华^1,2, 王江¹, 邓斌¹
AuthorsListE:Yuan Chunhua^1,2, Wang Jiang¹, Deng Bin¹
AuthorsHTMLE:Yuan Chunhua^1,2, Wang Jiang¹, Deng Bin¹
Unit:1. 天津大学电气自动化与信息工程学院，天津 300072；2. 沈阳理工大学自动化与电气工程学院，沈阳 110159
Unit_EngLish:1. School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China
2. School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang 110159, China
Abstract_Chinese:外电场会对神经系统的动力学行为产生影响, 但其作用机制尚不明确. 放电频率适应性是神经元动力学的一个显著特征, 它在神经系统的信息处理过程中起到了重要的作用. 为了研究不同神经元模型的适应性机制以及不同机制之间的对比, 基于Leaky Integrate-and-Fire(LIF)模型和Ermentrout模型, 建立了在直流外电场作用下改进的LIF和Ermentrout适应性模型. 通过分析不同模型的放电序列、初始和稳态放电频率曲线, 发现LIF模型有两种产生适应性的机制, 适应性电流机制使放电频率曲线水平移向高输入方向, 且斜率保持不变; 动态阈值机制使放电频率曲线呈发散状, 斜率递减. 而Ermentrout模型只有一种产生适应性的机制. 另外通过分析噪声下放电峰峰间期的相关系数和变异系数, 进一步阐明直流外电场对不同适应性机制的影响.
Abstract_English:The external electric field has effects on neuronal dynamics but its mechanisms are unknown. Spike-frequency adaption is an important characteristic of dynamics in nervous systems，which has been proved to process neuronal information by various ion channels. In order to investigate different spike-frequency mechanisms of diverse neuron models，based on Leaky Integrate-Fire (LIF) model and Ermentrout model，modified LIF models and Ermentrout model under external direct electric field are established in this paper. By analyzing the spiking trains，the curves of the onset spike frequency and the curves of the spike frequency of the steady state，different effects induced by the adaption under external electric field are shown in this paper. There are two mechanisms that can produce spike-frequency adaptation in LIF models. The adaptive current mechanism shifts the frequency curves to higher inputs without affecting its slope. On the other hand，the dynamic threshold mechanism has a divisive effect on the frequency curves. However，there is only one mechanism that can produce spike-frequency adaptation in Ermentrout model. The coefficient of correlation and the coefficient of variation of the inter-spike intervals are also studied to further illustrate the effects of external direct electric field on different kinds of adaption mechanisms.
Keyword_Chinese:放电频率适应性; 直流外电场; LIF模型; Ermentrout模型
Keywords_English:spike-frequency adaptation; external direct electric field; LIF model; Ermentrout model

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