dangleping@tju.edu.cn
化学工程
未公开
副研究员
干法中和过程碱基替代物的选择

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微流体界面作用对药物多晶型成核与生长的影响规律及机制

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微流体环境下界面作用对药物多晶型形成的影响规律及机制

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膜定向分子组装共结晶技术及机理的研究

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药物多晶型研究及其成核和生长机理探索

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能否将洗涤剂有效成分做成有机晶体

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电池级磷酸铁制备工艺研究

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有机药物超分子共结晶机理的探索

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基于熔融层结晶+减压发汗的油脂高效分提过程关键技术理论基础的研究

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批操作混合器中虫状胶束流体的流场表征与评估

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***工业化制造技术

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牙膏半连续过程生产能力和原料的研究

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牙膏中清凉/香味剂的沉积强化研究

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制药过程和生物材料过程工艺改造和优化研究
一种膜技术定向制备茶碱-糖精共晶的方法

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新美罗培南晶型及其制备方法

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乙水杨胺-糖精共晶晶型II的制备方法

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一种木糖醇/薄荷醇共结晶体及制备方法

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一种基于熔融层结晶技术分离乳脂肪的方法

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基于离子液体的诱导结晶效应调控溶菌酶生物活性的方法
本发明公开了一种膜技术定向制备茶碱-糖精共晶的方法,步骤为：(1)将玻璃片浸入Piranha溶液中,加热,取出,洗涤,干燥,得到羟基化玻璃片,放入含有硅烷偶联剂的水溶液中,室温、密闭放置,得到表面硅烷化的玻璃片；清洗,烘干,在玻璃片表面得到硅烷单分子自组装膜；(

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本发明涉及一种新美罗培南晶型及其制备方法。

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将步骤(1)获得的基片的一端固定放入混合液中，覆盖容器口部，室温下蒸发，使析出的乙水杨胺-糖精共晶晶体附着在所述基片上，乙水杨胺、糖精晶体沉到容器底部，取出基片，清洗，干燥，将乙水杨胺-糖精共晶晶体从基片上取下。本发明使脂肪酸在铝表面自组装产生的单分子自组装膜，使膜分子与药物分子之间的相互作用力定向诱导共晶的生长，在比较宽的浓度范围内，均能得到乙水杨胺-糖精共晶晶型II。

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本发明公开了一种木糖醇/薄荷醇共结晶体及制备方法,制备方法为：按质量比为5-15：1的比例称取原料木糖醇和薄荷醇,加入水或体积浓度为0.1%-10%的乙醇水溶液；所述原料与水或乙醇水溶液的质量比为5-2：1,在50℃-70℃在转速为200-350r/min的条件下搅拌,使木糖醇和薄荷醇溶解；在时间为3-30min降温至5℃-20℃,搅拌,使溶液转变成白色晶浆,抽滤,干燥,得到木糖醇/薄荷醇共结晶体。

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本发明公开了一种基于熔融层结晶技术分离乳脂肪的方法，包括以下步骤：（1）将无水乳脂肪搅拌下升高温度至60℃，恒温保持30min。待全部溶解后加入带双夹套结晶罐体中，（2）通过循环制冷液控制外层夹套温度40-45℃，30-60min内将内层结晶管温度降至35℃。（3）然后60-120min分别降至24-27℃、15-18℃及8-11℃。然后维持120min，内管外壁均匀生长晶层。

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本发明公开了一种基于离子液体的诱导结晶效应调控溶菌酶生物活性的方法,包括以下步骤：(1)将水溶性咪唑基离子液体加入到溶液A中,A溶液为pH值为4-6.5的、质量浓度为3-6%的NaCl的乙酸钠缓冲溶液；(2)将鸡蛋清溶菌酶加入到步骤(1)获得的液体中,使所述溶菌酶在20-30℃下过饱和比为1-3；(
Thermodynamics study on the theophylline-nicotinamidecocrystal

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Indicator of Cocrystal Stoichiometry in Solution: Local Composition and Its Application on Selective Cocrystal Growth

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Determination of Operating Conditions for Controlled Batch Crystallization of Mitomycin C

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Dehydration Mechanism and Kinetics of Monohydrate Racemic Tartaric Acid

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The Effect of Ionic Liquids on Solubility and Morphology of Lysozyme

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The Effect of Ionic Liquids on Solubility and Morphology of Lysozyme

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Dehydration Kinetics of Monohydrate Racemic Tartaric acid

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Is Stoichiometric Diversity of Cocrystals Determined by Solution Microstructure? Molecular Dynamics Approach And a Case Study

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Simulation of microwave thin layer drying process by a new theoretical model

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Journal of the Taiwan Institute of Chemical Engineers

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Insights into the dissolution mechanisms of detergent agglomerates: An approach to assess dissolution heterogeneity

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Gel formation and transformation of Moxidectin during the anti-solvent crystallization

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Insights into the Dissolution Kinetics of NaLAS Tablets

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Determination and correlation of solubility and solution thermodynamics of ethenzamide in different pure solvents

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Insights into Cocrystal Polymorphic Transformation Mechanism of Ethenzamide-Saccharin: A Combined Experimental and Simulative

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Solid-liquid phase equilibrium and ternary phase diagrams of ethenzamide-saccharin cocrystals in different solvents

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Phase Behavior of Commercial AES/Ethanol/H2O Ternary System

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Monitoring of Cocrystallization of Ethenzamide–Saccharin: Insight into Kinetic Process by In Situ Raman Spectroscopy

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Effect of supersaturation on l-glutamic acid polymorphs under droplet-based microchannels

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Selective Crystal Growth of Theophylline-Saccharin Cocrystal on Self-Assembled Monolayer from Incongruent System

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The in situ monitoring of transformation of Moxidectin Ethanol Solvate to Form Ⅰ in Ethanol-Water Mixture

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Crystallization Behavior of Palm Kernel Oil Monitored by in-situ FBRM and PVM during Suspension Crystallization

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谷胱甘肽在水-乙醇混合溶剂中的溶解度测定及关联

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Salting effects on the solubility and transformation kinetics of l -phenylalanine anhydrate/monohydrate in aqueous solutions

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Solid-liquid equilibrium of theophylline in solvent mixtures

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茶碱、烟酰胺与异丙醇三元系统在298.15和308.15K的相图研究

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Solid-liquid phase equilibrium of nicotinamide in different pure solvents: Measurements and thermodynamic modeling

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On the measurement of solubility

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Facile method for the prediction of anhydrate/hydrate transformation point

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The water activity aT[H2O] that corresponds to the transformation between hydrate and anhydrate forms of a drug is important

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Thermodynamic analysis of lipoic acid crystallized with additives

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Influence of polymorphs on the transformation water activity of theophylline

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Thermal, phase transition, and thermal kinetics studies of carbamazepine

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Nucleation behavior of glutathione polymorphs in water

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Solubility and pseudopolymorphic transitions in mixed solvent: Meropenem in methanol–water solution

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Ionic liquids as selectors for controlling the crystallization nucleation of hen egg white lysozyme

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Solid–liquid equilibrium of some polycyclic aromatic hydrocarbons in wash oil

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Analyzing Solution Complexation of Cocrystals by Mathematic Models and In-Situ ATR-FTIR Spectroscopy

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How to crystallize anhydrous racemic tartaric acid from an ethanol-water solution

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Solid-liquid phase equilibrium and solubility of dibenzo[ b, d ]furan and 9 H -fluoren-9-one in organic solvents

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Solid–liquid phase equilibrium of 9-fluorenone and several polynuclear aromatic hydrocarbons

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Crystallization of the polymorphs of succinic acid via sublimation at different temperatures in the presence or absence of wa

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Solid-liquid equilibrium of D- and L-tartaric acid and their importance for enantioseparation

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Solubility and metastable zone width of DL-tartaric acid in aqueous solution

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Solid-liquid phase equilibrium and phase diagram for the ternary carbamazepine-succinic acid-ethanol or acetone system at (29

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L-glutamic acid polymorph control using amino acid additives

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The Crystallization Control of Thermal Stability and Morphology of Hen Egg White Lysozyme crystals by Ionic Liquids

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Effects of ionic impurities on the crystal morphology of phosphoric acid hemihydrate

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Solubility of 5-(Dithiolan-3-yl)pentanoic acid in the mixed solvents of cyclohexane + ethyl acetate, heptane + ethyl acetate,

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Crystallization control of thermal stability and morphology of hen egg white lysozyme crystals by ionic liquids

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Cooling crystallization kinetics of acenaphthene by using a batch dynamic method

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The effect of temperature and solvent composition on transformation of β to α glycine as monitored in situ by FBRM and PVM

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Solubility of Carbamazepine (Form III) in Different Solvents from (275 to 343) K.

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Solubility of Fumaric Acid in Propan-2-ol, Ethanol, Acetone, Propan-1-ol, and Water

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Measurement of solubility of erythromycin acetone solvate in aqueous acetone solution between 298 K and 323 K

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Solubility of fluorene in Different Solvents from 278.98 K to 338.35 K