Fumihiko Nakamura——Professor
Nationality:


Phone:


Email:
fnakamura@tju.edu.cn

Office:
B210, 2F Building 24, School of Pharmaceutical Science and Technology, Tianjin University

School:
School of Pharmaceutical Science and Technology

ResearcherID:
N-5476-2016

Group weblink








Education Experience
1990-1993 Ph. D. Animal Science Tohoku University, Japan
1994-1995 Postdoctoral Cell Biology Stanford University

Professional Experience
1995-2000 Associate Professor Tohoku University
2001-2005 Research Fellow Brigham and Women's Hospital/Harvard Medical School
2006-2008 Instructor Brigham and Women's Hospital/Harvard Medical School
2008-2016 Assistant Professor Brigham and Women's Hospital/Harvard Medical School
2016- Professor Tianjin University

Research Area
The Nakamura group focuses on the regulation of the cellular actin cytoskeleton and in particular on the molecular mechanisms of chemical and mechanical signal transduction (mechanotransduction), a conversion of mechanical forces into cellular biochemical signals. Mechanotransduction is essential for many physiological processes in diverse organisms during development and maintenance of all tissues. Defects in mechanotransduction, often caused by mutations or deregulation of proteins that disturb cellular or extracellular mechanics, are implicated in the development of various diseases, ranging from muscular dystrophies and hypertension-induced vascular and cardiac hypertrophy to cancer progression and metastasis. Despite its importance, little is known about the underlying mechanisms of mechanotransduction. The group uses a wide range of techniques including proteomics, microscopy, molecular biology, and cell biology, and appreciate collaboration with expertises in structural biology, mechanical engineering, single molecular analysis, computer simulation, and drug design.




Honors and Awards
Japan society for the promotion of science for Japanese junior scientists
Nissan Science Foundation, Japan
Kurita Water and Environment Foundation, Japan
Naito Foundation, Japan
The HUSEC grant for an interdisciplinary seed proposal project, Harvard University, USA

Patents


Highlighted Publications
Wang, J., *Nakamura, F. Identification of Filamin A Mechanobinding Partner II: Fimbacin Is a Novel Actin Cross-Linking and Filamin A Binding Protein, Biochemistry, 2019, 10.1021/acs.biochem.9b00101
Wang, L., *Nakamura, F. Identification of Filamin A Mechanobinding Partner I: Smoothelin Specifically Interacts with the Filamin A Mechanosensitive Domain 21, Biochemistry, 2019, 10.1021/acs.biochem.9b00100
*Nakamura, F. Mechanotransduction in blood cells. Asia-Pacific Journal of Blood Types and Genes, 2017;1(1):1-9
Song M, He Q, Berk BA, Hartwig JH, Stossel TP, *Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016;469(3):659-64 PMID **
*Nakamura F, Song M, Hartwig JH, Stossel TP. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014;5:4656 PMID **, PMC **
*Nakamura F. FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration. Biochem J. 2013;453(1):17-25 PMID **
Ehrlicher AJ, *Nakamura F (co-first and corresponding author), Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 PMID **
Playford MP, Nurminen E, Pentikainen OT, Milgram SL, Hartwig JH, Stossel TP, *Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010;285(22):17156-65 PMID **, PMC **
*Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007;179(5):1011-25 PMID **
Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpelainen I, Munday AD, Hartwig JH, Stossel TP, Ylanne J. The structure of the GPIb-filamin A complex. Blood. 2006;107(5):1925-32 PMID **
Hishiya A, Ohnishi M, Tamura S, *Nakamura F. Protein phosphatase 2C inactivates F-actin binding of human platelet Moesin. J Biol Chem. 1999;274(38):26705-12
Nakamura F, Huang L, Pestonjamasp K, Luna EJ, Furthmayr H. Regulation of F-actin binding to platelet moesin In vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell. 1999;10(8):2669-85

ResearcherID Publications
Year Title Author(s) Source Volume
2016 An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu) Song, Mia; He, Qianjing; Berk, Benjamin-Andreas; et al. Biochemical and Biophysical Research Communications 469
2016 Arterial Myogenic Activation through Smooth Muscle Filamin A Retailleau, Kevin; Arhatte, Malika; Demolombe, Sophie; et al. Cell Reports 14
2016 DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk Justa-Schuch, Daniela; Silva-Garcia, Maria; Pilla, Esther; et al. Elife 5
2015 Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors Gomez-Mouton, Concepcion; Fischer, Thierry; Peregil, Rosa M.; et al. Blood 125
2015 FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets Begonja, Antonija Jurak; Pluthero, Fred G.; Suphamungmee, Worawit; et al. Blood 126
2014 Binding of WIP to Actin Is Essential for T Cell Actin Cytoskeleton Integrity and Tissue Homing Massaad, Michel J.; Oyoshi, Michiko K.; Kane, Jennifer; et al. Molecular and Cellular Biology 34
2014 Documentation and localization of force-mediated filamin A domain perturbations in moving cells Nakamura, Fumihiko; Song, Mia; Hartwig, John H.; et al. Nature Communications 5
2014 Remodeling of the Intestinal Brush Border Underlies Adhesion and Virulence of an Enteric Pathogen Zhou, Xiaohui; Massol, Ramiro H.; Nakamura, Fumihiko; et al. Mbio 5
2013 Domain-Domain Interactions in Filamin A (16-23) Impose a Hierarchy of Unfolding Forces Xu, Tianyou; Lannon, Herbert; Wolf, Sebastein; et al. Biophysical Journal 104
2013 Filamin-A Regulates Neutrophil Uropod Retraction through RhoA during Chemotaxis Sun, Chunxiang; Forster, Carol; Nakamura, Fumihiko; et al. Plos One 8