姓名 韩贵芳
职称
讲师
所在部门
药学院
研究方向
药物化学
有机化学


办公室
药学院B楼409
办公电话

电子邮箱
hanguifang@tmu.edu.cn

教育背景

2003.09–2007.07 北京化工大学专业：制药工程 学士
2010.09–2015.06 南开大学专业：农药学（元素有机化学国家重点实验室） 农药学博士

工作经历

2015.07–至今天津医科大学药学院药物化学讲师
2007.07–2010.09 药明康德新药开发有限公司助理研究员

研究成果（本人具有代表性的论著、论文及主持的科研项目）

论文增加

1.Guifang Han,# Li Xue,# Lili Zhao, Tiaozhen Zhu, Jingli Hou, Yuguang Song*, Yangping Liu*Access to CF₃‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction. Adv. Synth. Catal. 2019,361, 678-682.(VIP Paper) (IF: 5.123)
2.Guifang Han, Linwei Chen, Qiang Wang, Meng Wu, Yuxiu Liu, and QingminWang*Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids. J. Agric. Food Chem., 2018, 66 (4), 780–788. (IF: 3.412)
3. Yuxiu Liu, Lihua Qing, ChuisongMeng, Jiajie Shi, Yan Yang, Ziwen Wang, Guifang Han, Yi Wang, Jian Ding, Ling-huaMeng*, and Qingmin Wang* 6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression. J. Med. Chem., 2017, 60 (7), 2764–2779.
4.Guifang Han, Qiang Wang, Linwei Chen, Yuxiu Liu, and Qingmin Wang* Copper-Catalyzed Trifluoromethylation of Acrylamide Coupled with Dearomatization of Indole: Access to CF3?Containing Spiro[indole-3,3'-pyrrolidine]. Adv. Synth. Catal. 2016, 358(4), 561-566. (IF: 5.123)
5.Guifang Han, Yuxiu Liu, and Qingmin Wang*. Copper-Catalyzed IntramolecularTrifluoromethylation of N?Benzylacrylamides Coupled with Dearomatization: Access to CF3?Containing 2?Azaspiro[4.5]decanes. Org. Lett. 2014, 16, 3188?3191. (IF: 6.492)
6.Guifang Han, Qiang Wang, Yuxiu Liu, and Qingmin Wang* Copper-Mediated α-Trifluoromethylation of N-phenylcinnamamides Coupled with Dearomatization: Access to Trifluoromethylated 1-Azaspiro[4.5]decanes. Org. Lett. 2014, 16, 5914-5917. (IF: 6.492)
7. Guifang Han, Yuxiu Liu, and Qingmin Wang*. Total Synthesis of Phenanthroindolizidine Alkaloids through an Amidyl Radical Cascade/Rearrangement Reaction. Org. Lett. 2013, 15, 5334?5337. (IF: 6.492)
8. Wenbo Liu, JiangpingNie, Xiaoli Tan, Huiqiang Liu, Nannan Yu, Guifang Han, Yutian Zhu, Frederick A. Villamena, Yuguang Song, Jay L. Zweier,*and Yangping Liu*. Synthesis and Characterization of PEGylated Trityl Radicals: Effect of PEGylation on Physicochemical Properties. J. Org. Chem. 2017, 82, 588-596
9.Qiang Wang, Guifang Han, Yuxiu Liu, and Qingmin Wang*. Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2(1H)-ones. Adv. Synth. Catal. 2015, 357, 2464–2468.
10. Meng Wu, Guifang Han, Chuisong Meng, Ziwen Wang, Yuxiu Liu, and Qingmin Wang*. Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of glycoconjugates of phenanthroindolizidines alkaloids. Mol. Divers. 2014, 18, 25?37.
11.Meng Wu, Guifang Han, Ziwen Wang, Yuxiu Liu, and Qingmin Wang*.Synthesis and Antiviral Activities of Antofine Analogues with Different C-6 Substituent Groups.J. Agric. Food Chem.2013, 61, 1030?1035.
12.Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Meng Wu, Guifang Han, Yaxin Lu*, Qingming Wang*, and Zheng Yin*. Optimization of on-line solid phase extraction and HPLC conditions using response surface methodology for determination of WM-5 in mouse plasma and its application to pharmacokinetic study. J. Chromatogr. B2013, 923?924.
13. Ziwen Wang, Meng Wu, Yi Wang, Zheng Li, Lei Wang,Guifang Han, Fazhong Chen, Yuxiu Liu, Kailiang Wang, Ao Zhang*,LinghuaMeng*, and Qingmin Wang*.Synthesis and SAR Studies of Phenanthroindolizidine and Phenanthroquinolizidine Alkaloids as Potent Anti-tumor Agents. Eur. J. Med. Chem. 2012, 51, 250?258.

科研项目

1.基于可逆反应与谱线比例方式检测谷胱甘肽新型EPR探针的设计、合成及性能研究.国家自然科学青年基金主持在研
2.含三氟甲基氮杂螺环的高效构筑及顺磁共振在反应机理中应用研究. 天津市自然科学基金青年项目主持.在研
3.交换相互作用和弛豫时间可调的杂化双自由基的设计合成与高场动态核极化性能研究，国家自然科学基金面上项目.参与在研
4.基于p7三维核磁结构抗丙肝病毒抑制剂研究.国家自然科学面上基金参与在研

荣誉奖励

1. 2016年天津市“131”创新性人才第三层次
2. 2015年获得南开大学优秀毕业生；