姓名
董彩霞
职称
讲师
所在部门
药学院
研究方向
生药学


办公室
药学院A417
办公电话

电子邮箱
dongcaixia@tmu.edu.cn

教育背景

2003年7月 河北科技大学，化工学院，制药工程专业，工学学士学位
2006年7月 陕西中医药大学，药学院，中药学专业，医学硕士学位
北京大学医学部，药学院，天然药物学专业，联合培养硕士研究生(2004年8月—2006年5月)
2011年9月 日本富山大学，医学药学教育部，生药学专业，药学博士学位

工作经历

2013年11月—今 讲师，天津医科大学
2011年11月—2013年10月 博士后研究员，香港浸会大学
2006年7月—2008年9月 研究员，以岭医药集团北京以岭医药研究院

研究成果（本人具有代表性的论著、论文及主持的科研项目）

论著及编著
Caixia Dong, Quanbin Han.Ganoderma lucidum(Lingzhi, Ganoderma). Yanze Liu, Zhimin Wang, Junzeng Zhang (Eds),Dietary Chinese Herbs.Springer Vienna,DOI 10.1007/978-3-211-99448-1_85. 2015, pp759-766.

论文

1. Cai-Xia Dong*, Wensheng Zhang, Qi-Li Sun , Yun-Jia Jiang, Zheng Fu, Ying Zhang, Juan Du, Yuanxia Sun, Ning Tao*, Zhi Yao*. Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression..Int J Biol Macromol. 2018,115:1233-1240. (IF: 3.929) PMID: ** DOI: 10.1016/j.ijbiomac.2018.04.153

2. Cai-Xia Dong*, Liu Liu, Chang-Ying Wang, Zheng Fu, Ying Zhang, Xuan Hou, Chao Peng, Rui-Xue Ran, Zhi Yao*. Structural characterization of polysaccharides from Saposhnikovia divaricata and their antagonistic effects against the immunosuppression by the culture supernatants of melanoma cells on RAW264.7 macrophages. Int J Biol Macromol. 2018, 113, 748-756. (IF: 3.929) PMID: ** DOI: 10.1016/j.ijbiomac.2018.03.022

3. Zhuo-Er Chen, Reziyamu Wufuer, Jin-Hu Ji, Jin-Fang Li, Yu-Feng Cheng, Cai-Xia Dong*, Hailiqian Taoerdahong*. Structural characterization and immunostimulatory activity of polysaccharides from Brassica rapa L.. J Agric Food Chem. 2017. 65(44): 9685-9692. (SCI, IF: 3.504)

4. Cai-Xia Dong*, Li-Jiao Zhang, Rong Xu, Gong Zhang, Ying-Biao Zhou, Xiao-Qiang Han, Ying Zhang, Yuan-Xia Sun*, Structural Characterization and Immunostimulating Activities of a Levan-type Fructan from Curcuma kwangsiensis. Int J Biol Macromol. 2015, 77, 99-104. (SCI, 5-Year IF: 3.929)

5. Jing Xu, Dan Chen, Chang Liu, Xiong-Zhi Wu, Cai-Xia Dong*, Jing Zhou*, Structural Characterization and Anti-tumor Effects of an Inulin-type Fructan Isolated from Atractylodes chinensis. Int J Biol Macromol. 2016, 82, 765-771. (SCI,5-Year IF: 3.929)

6. Cai-Xia Dong, Kyoko Hayashi, Yusuke Mizukoshi, Jung-Bum Lee, Toshimitsu Hayashi. Structures of pectic polysaccharides from Basella rubra L. and their antiviral effects. Carbohydr polym. 2011,84 (3):1084-1092. (SCI, IF: 5.158)

7. Cai-Xia Dong, Kyoko Hayashi, Yusuke Mizukoshi, Jung-Bum Lee, Toshimitsu Hayashi. Characterization of structures and anti-herpetic effects of neutral polysaccharides from Basella rubra L. Int J Biol Macromol. 2012,50 (1): 245-249. (SCI, IF: 3.929)

8. Cai-Xia Dong, Kyoko Hayashi, Jung-Bum Lee and Toshimitsu Hayashi. Characterization of structures and antiviral effects of polysaccharides from Portulaca oleracea L., Chem & Pharm Bulletin. 2010,58(4): 507-510. (SCI, IF: 1.698)

9.Longhai Dai, Can Liu, Jiao Li, Caixia Dong, Jiangang Yang, Zhubo Dai, Xueli Zhang, Yuanxia Sun*. One-Pot Synthesis of Ginsenoside Rh2 and bioactive unnatural ginsenoside by coupling promiscuous glycosyltransferase from Bacillus subtilis 168 to sucrose synthase, J Agric Food Chem. 2018, 66(11):2830-2837. (5-Year IF: 3.504) PMID: ** DOI: 10.1021/acs.jafc.8b00597

10.Jiangang Yang, Yueming Zhu, Ge Qu, Yan Zeng, Chaoyu Tian, Caixia Dong, Yan Men, Longhai Dai, Zhoutong Sun*, Yuanxia Sun, Yanhe Ma*. Biosynthesis of dendroketose from different carbon sources using in vitro and in vivo metabolic engineering strategies. Biotechnol Biofuels. 2018; 11: 290. (IF: 5.497) PMID: ** PMCID: PMC** DOI: 10.1186/s13068-018-1293-7.

11.Longhai Dai, Jiao Li, Jiangang Yang, Yueming Zhu, Yan Men, Yan Zeng, Yi Cai, Caixia Dong, Zhubo Dai, Xueli Zhang*, Yuanxia Sun*. Use of a Promiscuous Glycosyltransferase from Bacillus subtilis 168 for the Enzymatic Synthesis of Novel Protopanaxatriol-Type Ginsenosides. J Agric Food Chem. 2018, 66(4):943-949. (SCI, 5-Year IF: 3.504)

12.Yingbiao Zhou, Yueming Zhu, Yan Men, Caixia Dong, Yuanxia Sun*, Juankun Zhang*. ConstructionofengineeredSaccharomycescerevisiaestraintoimprovethatwhole-cell biocatalytic production of melibiose from raffinose. J Ind Microbiol. 2017.44(3):489-501. (SCI, IF: 2.870)

13.Jitao Li, Jiangang Yang, Yan Men, Yan Zeng, Yueming Zhu, Caixia Dong, Yuanxia Sun, Yanhe Ma, Biosynthesis of 2-deoxysugars using whole-cell catalyst expressing 2-deoxy-D-ribose 5-phosphate aldolase. Appl Microbiol Biotechnol. 2015, 99 (19): 7963-7972. (SCI, IF: 3.337)

14.Gopinath C. B. Subash, Kyoko Hayashi, Jung-Bum Lee, Tomoko Kamori, Cai-Xia Dong, Toshimitsu Hayashi. Analysis of compounds that interfere with herpes simplex virus-host receptor interactions using surface plasmon resonance. Anal Chem. 2013, 85(21):10455-10462. (SCI, IF: 5.695)

15.Quan-Bin Han, Wai-Lun Tang, Cai-Xia Dong, Hong-Xi Xu, Zhi-Hong Jiang. An interesting two-phase solvent system and its use in preparative isolation of aconitines from aconite roots by counter-currentchromatography. J Sep Sci. 2013, 36(7):1304-1310. (SCI, IF: 2.733)

16.Xiao-Qiang Han, Gar-Lee Yue., Rui-Qi Yue, Cai-Xia Dong, Chung-Lap Chan, Chun-Hay Ko, Wing Shing Cheung1, Ke-Wang Luo1, Hui Dai, Chun-Kwok Wong, Ping-Chung Leung, Quan-Bin Han. Structure Elucidation and Immunomodulatory Activity of A Beta Glucan from the Fruiting Bodies of Ganoderma sinense. Plos One. 2014 9(7):1-10. (SCI, IF: 3.73)

17.Xiao-Qiang Han, Ben Chung Lap Chan, Cai-Xia Dong, Yin-Hua Yang, Chun-Hay Ko, et al. Isolation, structure characterization, and immunomodulating Activity of a hyperbranched polysaccharide from the fruiting bodies of Ganoderma sinense. J Agric Food Chem. 2012, 60(17): 4267-4281. (SCI, IF: 2.823)

18.Xiao-qiang Han, Ben Chung Lap Chan, Hua Yu, Yin-Hua Yang, Shui-Qing Hu, Chun-Hay Ko, Cai-xia Dong, et al.Structural characterization and immunomodulating activities of a polysaccharide fromGanoderma sinense. Int J Biol Macromol. 2012, 51, 597-603. (SCI,5-Year IF: 3.929)





19.Cai-Xia Dong, She-Po Shi, Ming-Bo Zhao, Peng-Fei Tu. A new glucopyranosyl naphthalene from Clematis hexapetala Pall. Chinese Journal of Natural Medicines. 6(1): 0023-0025, 2008. (SCI, IF: 1.114)

20. Cai-Xia Dong, She-Po Shi, Ke-Si Wu, Peng-Fei Tu. Chemical constituents from the roots andrhizomes of Clematis hexapetala Pall. Zeitschrift für Naturforschung B-Chemical Sciences. 2007,62b(6): 854-858. (SCI, IF: 0.772)

21. Cai-Xia Dong, Ke-Si Wu, She-Po Shi, Peng-Fei Tu. Flavanoids from Clematis hexapetala. J Chin Pharm Sci. 2006,15(1): 15-20.

22.She-Po Shi, Cai-Xia Dong, Dan Jiang, Peng-Fei Tu. Macrocyclic Glycosides from Clematis hexapetala. Helvetic Chimica Acta. 2006,89(12): 3002-3006. (SCI, IF: 1.383)

23.She-Po Shi, Dan Jiang, Cai-Xia Dong, Peng-Fei Tu. Macrocyclic glucosides from Clematis mandshurica. Biochem Syst Ecol2007,35(1): 57-60. (SCI, IF: 0.967)

24.Shi She-po, Jang Dan, Dong Cai-xia, Tu Peng-fei. Triterpene saponins from Clematis mandshurica. J Nat Prod. 2006,69 (11): 1591-1595. (SCI, IF: 3.798)

25.She-Po Shi, Dan Jiang, Cai-Xia Dong, Peng-Fei Tu. New Phenolic Glycosides from Clematis mandshurica. Helv Chim Acta. 2006,89(5): 1023-1029. (SCI, IF: 1.383)

26.She-Po Shi, Dan Jiang, Cai-Xia Dong, and Pengd-Fei Tu. Lignans from the roots and rhizomes of Clematis manshurica. Zeitschrift für Naturforschung B-Chemical Sciences. 2006, 61(10): 1299-1303. (SCI, IF: 0.772)

27.She-Po Shi, Peng-Fei Tu, Cai-Xia Dong, Dan Jiang. Alkaloids from Clematis manshurica Rupr. J Asi Nat Prod Res. 2006, 8(1-2): 73-78. (SCI, IF: 0.913)

28. 董彩霞, 史社坡, 武可泗, 屠鹏飞. 棉团铁线莲化学成分研究I. 中国中药杂志31 (20): 1696-1699, 2006.

29.史社坡, 蒋丹, 董彩霞, 屠鹏飞.东北铁线莲化学成分研究. 中草药. 38(3): 335-337, 2007. （CSCI: 1.453; ID: 0253-2670）











科研项目

1.国家自然科学青年基金：莪术多糖CKAP-2逆转髓源抑制细胞（MDSC）介导免疫功能抑制的作用机制研究（**），2019.01-2021.12，主持
2.天津市科委项目：亨氏马尾藻抗II型疱疹病毒的药效物质基础及作用机理研究项目 （15JCYBJC50700），2015.4-2018.3，主持
3.横向课题：某植物多糖组分化学结构特征分析及结构鉴定，2018.11-2019.12，主持
4.横向课题：新疆特色资源库尔勒香梨均一多糖的分离、结构分析与鉴定，2018.8-2019.04，主持
5.横向课题：维药恰麻古多糖的分离纯化及结构特征分析, 2016.5-2016.12，主持


其他事项


主讲课程：
药学、药物制剂专业《药用植物学》、《药用植物学实验》
药学、药物制剂专业《生药学实验》

研究方向：
1.中药及天然药物中糖类药效物质的研究及其在抗病毒、抗肿瘤及机体免疫调节方面的功能评价
2.基于药食两用植物的功能食品的研究开发
3.基于糖类成分的中药及天然药物的质量控制

社会兼职
1. Pharmacon (ISSN: 1411-4283) 杂志编委（Editorial Board）
2. Carbohydrate Polymers, Journal of Agricultural and Food Chemistry, Food and Chemical Toxicology, International Journal of Biological Macromolecules, Process Biochemistry, Biomedicine & Pharmacotherapy等杂志审稿人
3. 中国民族医药学会药用资源分会常务理事
4. 世界中医药联合会中医药免疫专业委员会会员