韩际宏



招生专业： 生物化学与分子生物学
电话： **

邮箱： jihonghan2008@nankai.edu.cn
办公地点： 新生物站A-306







个人资料
性别： 男
部门： 生物化学与分子生物学系
联系电话： **
通讯地址： 天津南开大学生命科学学院
职称： 教授
电子邮箱： jihonghan2008@nankai.edu.cn
办公地址： 新生物站A-306


教育经历
1987: 学士, 化学, 南开大学, 中国天津；1989: 硕士, 化学, 南开大学，中国天津；1995: 博士, 生物化学, 康乃尔大学医学院 (Cornell Univ Med Coll)，美国纽约

工作经历
1994-1995: 分子生物学博士后 (Post-doctoral Fellow in Molecular Biology), 西奈山医学院 (Mount Sinai School of Medicine), 美国纽约；1996-1999: 血管生物学研究员(Research Associate in Vascular Biology), 康乃尔大学医学院,血管生物学中心, 美国纽约(Center of Vascular Biology, Cornell University Medical College, New York, USA)；1999–2004: 助理教授 (Assistant Professor of Pathology), 血管生物学中心, 康乃尔大学医学院, 美国纽约；2004–2007: 副教授 (Associate Professor of Pathology), 血管生物学中心, 康乃尔大学医学院, 美国纽约； 2007-至今: 南开大学生命科学学院特聘杰出教授；2007-2015：南开大学生命科学学院生物化学与分子生物学系系主任；2010-2014: 科技部973计划首席科学家；2014-2017: 南开大学生命科学学院副院长


个人简介
韩际宏，理学博士、教授、博导。1987年毕业于南开大学化学系、获学士学位，1989年毕业于南开大学高分子研究所、获硕士学位，1995年毕业于美国康奈尔大学医学院（Cornell University Medical College）、获博士学位。曾任美国康奈尔大学副教授（2004年）、南开大学杰出****（2007年）；973首席科学家（2010）；国家重大研究计划与专项、国家自然科学基金委、科技部科技奖励等评审专家；Scientific Reports编委，ATVB、Circulation、Cir Res、JBC、JLR等国际知名期刊审稿人。主持多项国家自然科学基金委、科技部、横向合作课题。主要研究动脉粥样硬化发病机制、糖尿病、脂代谢对肺癌的影响、中药防治重大疾病机理；在Circulation、Hepatology、PNAS、Immunity、ATVB、Am J Pathol、JBC等期刊发表论文，论文被引近3000次，获中国发明专利授权1项，获教育部高等学校科学研究优秀成果自然科学二等奖（第一完成人），中华医学会医学科学技术奖三等奖（第一完成人），2015年、2017年南开大学优秀博士论文指导教师。


研究方向
动脉粥样硬化发病机制；糖尿病发病机制与治疗；脂代谢在肺癌发生与治疗中的作用；中药防治重大疾病机理；胆汁淤积性肝病病理机制与防治



科研成果
2010年后发表的论文(*: 通讯作者)
1.Liang Y, Han H, Liu L, Duan Y, Yang X, Ma C, Zhu Y, Han J, Li X, Chen Y. CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells. Oncogenesis2018, in revision.
2. Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J*, Yang X*. LongShengZhi capsule reduces established atherosclerotic lesions in apoE deficient mice. Journal of Cardiovascular Pharmacology2018, accepted.
3. Liu L, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J*, Chen Y. Inhibition of vascular calcification—A new anti-atherogenic mechanism of DNA topoisomerase II inhibitors. Arteriosclerosis, Thrombosis and Vascular Biology,2018;38:2382-2395.
4. Liu Y, Wei Z, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Gu J, Liu J, Han J, Yang X, Duan Y. Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. Journal of Lipid Research, 2018, in revision.
5. Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y, Gao X, Li X, Duan Y, Han J*, Yang X*. NaoXinTong capsule inhibits carrageenan-induced thrombosis in mice. Journal of Cardiovascular Pharmacology2018;72:49-59.
6. Yang, S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J*,Yang X*. NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/dbmice. Scientific Reports2018;8:9158.
7. Ma C, Zhang W, Liu Y, Liu L, Yang X, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Miao QR, Zhu Y, Han J*, Chen Y*, Duan Y*. Functional interplay between LXR and AMPKalpha reduces inhibits atherosclerosis tic lesions in apoE knockout mice-deficient mice--A new anti-atherogenic strategy. British Journal of Pharmacology2018;175:1486-1503.
8. Owoicho Orgah J, Wang M, Yang X, Wang Z, Wang D, Zhang Q, Fan G, Han J, Qin G, Gao X, Zhu Y. Danhong Injection protects against hypertension-induced renal injury viadown-regulation of myoglobin expression in spontaneously hypertensive rats. Kidney Blood Press Res. 2018;43:12-24.
9. Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Yu M, Ma C, Gu J, Miao RQ, Hajjar DP, Han J*, Duan Y*. 25-Hydroxycholesterol induces its own production by activating cholesterol 25-hydroxylase expression in an LXR dependent mechanism. Journal of Lipid Research, 2018;59:439-451.
10. Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao QR*, Han J*, Duan Y*. Activation of hepatic Nogo-B receptor expression--A new anti-liver steatosis mechanism of statins. BBA-Molecular Cell Biology of Lipid, 2018;1863:177-190.
11. Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J, Zhu Y. Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis.Journal of Ethnopharmacology.2018;211:358-365.
12. Lyu M, Yan C, Liu H, Chen X, Wang Y, Han J, Fan G, Zhu Y. Network pharmacology exploration reveals endothelial inflammation as a common target for coronary artery disease and stroke treatment by Danhong injection. Scientific Reports2017;7:15427.
13. Yang X, Orgah J, Wang D, Fan G, Jingyang H, Han J,Qin G, Gao X, Zhu Y. Danhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive rats. Scientific Reports.2017;7:4308.
14. Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao Q, Han J*, Duan Y*. Activation of adiponectin receptor regulates proprotein convertase subtilisin/kexin type 9 expression and inhibits lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology2017;37:1290-1300.
15. Yu M, Liu Y, Duan Y, Chen Y, Han J, Sun L, Yang X. Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis--a unique anti-oxidative stress mechanism in mice. Biochemical and Biophysical Research Communications2017;484:56-63.
16. Yang X, Li Y, Sun L, Liu Y, Ma C, Chen Y, Tan H, Li Q, Li X, Wang Y, Duan Y, Zhao B*, Han J*.NaoXinTong enhances atorvastatin-reduced atherosclerosis while antagonizing atorvastatin-induced hepatic inflammation. Journal of Cardiovascular Pharmacology2017;69:55-64.
17. He S, Zhao T, Guo H, Meng Y, Qin G, Goukassian DA, Han J, Gao X, Zhu Y. Coordinated activation of VEGF/VEGFR-2 and PPARdpathways by a multi-component Chinese medicine DHI accelerated recovery from peripheral arterial disease in type 2 diabetic mice. PLoS One. 2016;11:e**.
18. Zhang K, Cai HX, Gao S, Yang GL, Deng HT, Xu GC, Han J, Zhang QZ, Li LY. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression viaactivation of JNK-GATA3 signals. Oncotarget2016;7:69436-69449.
19. Hu W, Zhang W, Chen Y, Rana U, Teng R, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J*, Miao QR*. Nogo-B receptor deficiency increases LXRalphanuclear translocation and hepatic lipogenesis. Hepatology2016;64:1559-1576.
20. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*. 2016. Inhibition of macrophage CD36 expression and cellular oxLDL accumulation by tamoxifen--A PPARgammadependent mechanism. The Journal of Biological Chemistry2016;291:16977-89 (封面论文).
21. Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Yajun Duan*. 2016 Activation of PPARgammaand CD36 expression--the dual pathophysiological role of progesterone. The Journal of Biological Chemistry2016;291:15108-18.
22. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li LY, Miao QR, Hajjar DP, Duan Y*, Han J*. 2016. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport--an anti-atherogenic function of ERK1/2 inhibition. BBA-Molecular and Cell Biology of Lipid2016;1861:1180-1191.
23. Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. 2016. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene. Scientific Reports2016;6:27295.
24. Yang M, Orgah J, Zhu J, Fan G, Han J, Wang X, Zhang B, Zhu Y. Danhong Injection attenuates cardiac injury induced by ischemic and reperfused neuronal cells through regulating arginine vasopressin expression and secretion. Brain Research 2016;1642:516-23.
25. Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X. JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes viadistinct mechanisms. Oncotarget2016;7:29387-99.
26. Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J,Duan Y, Chen Y. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochemical and Biophysical Research Communications2016;473:939-46.
27. Liu M, Zhang W, Li X, Han J, Chen Y, Duan Y. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications2016;469;456-462.
28. Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology2016;67:203-11.
29. Yang X, Yao H, Chen Y, Sun L, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. The Journal of Biological Chemistry2015;290:21788-21799.
30. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J^*, Duan Y*. Administration of Danhong Injection to diabetic db/dbmice inhibits the development of diabetic retinopathy and nephropathy. Scientific Reports2015;5,11219; doi: 10.1038/srep11219.
31. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang X, Duan Y, Han J*. Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II. The Journal of Biological Chemistry2015;290:14418–14429.
32. Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE^-/-mice. Journal of Cardiovascular Pharmacology2015;66:189-95.
33. Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*.Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. BBA-Molecular Basis of Diseases2015;1852:1038-1048.
34. Chen Y, Duan Y, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J*.Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology2015;35:948-959.
35. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J,Li X*, Duan Y*. NaoXinTong inhibits the development of diabetic retinopathy in db/dbmice. Evidence-Based Complementary and Alternative MedicineVolume 2015; Article ID 242517, 8 pages, http://dx.doi.org/10.1155/2015/242517.
36. Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*.Inhibition of tumor growth by U0126 is associated with induction of interferon-gproduction.International Journal of Cancer2015;136:771-783(封面论文).
37. Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*.Identification of interferon-gammaas a new molecular target of liver X receptor. Biochemical Journal2014;459:345-354 (专评论文: Biochemical Journal. 2014;459:e1-e3).
38. Chen Y,Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong Injection inhibits the development of atherosclerosis in both Apoe^-/-and Ldlr^-/-mice. Journal of Cardiovascular Pharmacology2014;63:441-452.
39. Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin2014;59:1366-1373.
40. Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells2013;31:2538-2550.
41. Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of GR and PPARgamma pathways. Biochemical Journal2013;454:467-477.
42. Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochemical Biophysical Research Communication2013;432:643-649.
43. Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux---an LXR-dependent mechanism. BBA-Molecular and Cell Biology of Lipids2013;1831:1134-1145.
44. Meng X, Zhang Y, Jia Z, Huo X, He X, Tian G, Wu M, Wang Z, Zhou X, Xiong S, Gao X, Wu Z, Han J, Zhao L, Wang P, Hong Z, Wang Q, Yin Z. A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis. Journal of Leukocyte Biology2013;93:83-93.
45. Chen Y, Duan Y*, Kang Y, Yang X, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, HanJ*. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry 2012;287:43340-43350.
46. Duan Y, Chen Y, Hu W, Li X, ZhouX, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q, Han J*.PPARgammaactivation by ligands and dephosphorylation induces PCSK9 and LDLR expression.The Journal of Biological Chemistry2012;287:23667-23677.
47. Hu W, Zhou X, Jiang N, Duan Y, Chen Y, Li X, Yin Z, He G, Yao Z, Zhu Y, Hajjar DP, Han J*.Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis 2012;222:434-443.
48. Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials2012;33:2880-2891.
49. Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, Yin Z. Vgamm4gammadelta T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis.The Journal of Immunology2011;187:5007-5014.
50. Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'Brien RL, Born WK, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. Regulatory role ofVgamm4gammadeltacells in tumor immunity through IL-4 production.The Journal of Immunology2011;187:4979-4986.
51. Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J*.Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis2011;218:435-442.
52. He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated Vgamma4deltaT cells play a protective role in tumor immunity through expression of eomesodermin.The Journal of Immunology2010;185:126-133.
53. Zhou X, Yin Z, Guo X, Hajjar DP, Han J*. Inhibition of ERK1/2 and activation of LXR synergistically induce macrophage ABCA1 expression and cholesterol efflux. The Journal of Biological Chemistry 2010;285:6316-6326.



社会兼职
中国生物化学与分子生物学会脂质与脂蛋白专业委员会常务委员
天津生物化学与分子生物学会理事会副理事长
天津神经学会理事会副理事长



教学经历
本科生“英文生物化学”
研究生“心血管生物学研究进展”



荣誉称号
“中药大品种丹红注射液药效物质基础、作用机制、质量控制及产业化” 中华中医药学会科学技术奖一等奖，2015年，证书号：201501-07 ZY-13-R-4，第四完成人;
“动脉粥样硬化干预靶点与机制研究”，教育部高等学校科学研究优秀成果自然科学二等奖，2017年，第一完成人;
Acta Pharmacologica SinicaOutstanding Reviewer Award in 2016;
2015年、2017年南开大学优秀博士论文指导教师.