李磊



招生专业： 植物学
电话： 022-2350 8469

邮箱： lei.li@nankai.edu.cn
办公地点： 生物楼122







个人资料
性别： 男
部门： 植物生物学和生态学系
联系电话： 022-2350 8469
通讯地址： 天津市卫津路94号南开大学生物站106（实验室）
职称： 教授
电子邮箱： lei.li@nankai.edu.cn
办公地址： 生物楼122


教育经历
2009-2013年于澳大利亚西澳大学获得植物生物化学博士学位

工作经历
2012.11-2018.9任澳大利亚植物能源中心（ARC Centre of Excellence in Plant Energy biology）助理研究员


个人简介
2009-2013年于澳大利亚西澳大学获得植物生物化学博士学位，2012.11-2018.9任澳大利亚植物能源中心（ARC Centre of Excellence in Plant Energy biology）助理研究员，期间至比利时VIB所短期合作研究，2018年9月受聘南开大学生命科学学院教授。李磊教授一直致力于植物生物化学研究，开展了蛋白稳定性、蛋白复合体组装和蛋白降解途径的研究。已发表学术论文14篇，累计影响因子超过80，H-index为11，其中第一作者文章七篇，包括Trends in Plant Science (1篇)、 Plant Cell (1篇)、Molecular & Cellular Proteomics (1篇)、Plant Journal (1篇)和JBC（2篇），多次受邀在全澳生物化学和国际蛋白组学会议做主题报告，2017年被中澳科学和技术创新大会授予“青年科学家奖”。担任知名植物学期刊Frontiers in Plant Science蛋白组学方向审稿编辑，同时为Nature Plants、Plant Journal、Plant Physiology、New Phytologist、Journal of Proteome Research等重要学术期刊审稿。


研究方向
我们课题组主要利用生物化学，质谱蛋白质组学和细胞生物学等技术手段进行植物线粒体和叶绿体蛋白质稳态调控的研究。蛋白质周转率即蛋白的合成和降解循环是生物细胞内重要的能量消耗过程，蛋白质周转率研究是蛋白质组学研究的新热点，单个蛋白质分子合成和降解速率及其耗能测定平台的建立为回答：mRNA和其所翻译蛋白丰度不匹配，蛋白水解酶和自噬选择性降解途径调控，线粒体和叶绿体功能受损引发的植物生长和发育受损及衰老机制等一系列生物学问题提供了新的思路。欢迎访问李磊实验室https://leililab2018.wixsite.com/leililab




科研成果
1. Li, L, Aro E-M, Millar AH (2018) Mechanisms of Photodamage and Protein Turnover in Photoinhibition. Trends in plant science10.1016/j.tplants.2018.05.004
2. Li L, Nelson CJ, Trosch J, Castleden I, Shaobai H, Millar AH (2017) Protein degradation rate in Arabidopsis thaliana leaf gowth and development. The Plant Cell10.1105/tpc.16.00768
F1000 Recommendations http://f1000.com/prime/?bd=1
Research Highlight by ARC http://www.arc.gov.au/teaching-plants-be-better-spenders
Altmetric Attention score is No.1of 54 similar age publications in The Plant Cell; and TOP 1% over nearly 2400 outputs from The Plant Cell https://plant.altmetric.com/details/**#score
3. Li L, Nelson CJ, Trosch J, Pruzinska A, Millar AH and Shaobai Huang (2016)Changes in specific protein turnover in Arabidopsis reveal multiple roles of Lon1 in mitochondrial protein homeostasis The Plant Journal 89 (3): 458-471
Media Release https://www.scimex.org/newsfeed/unravelling-the-role-of-plant-growth-protein-could-provide-clues-for-human-health
4. Li L, Nelson CJ, Solheim C, Whelan J, Millar AH (2012) Determining degradation and synthesis rates of arabidopsis proteins using the kinetics of progressive ¹⁵N labeling of two-dimensional gel-separated protein spots. Mol Cell Proteomics 11: M111 010025
5. Li L, Nelson CJ, Carrie C, Gawryluk R, Solheim C, Gray MW, Whelan J, Millar AH(2013) Subcomplexes of ancestral respiratory complex I subunits rapidly turn over in vivoas producible assembly intermediates in Arabidopsis. J Biol Chem 288: 5707-5717
6. Li L, Carrie C, Nelson C, Whelan J, Millar AH (2012) Accumulation of Newly Synthesized F₁in vivoin Arabidopsis Mitochondria Provides Evidence for Modular Assembly of the Plant F1Fo ATP Synthase. J Biol Chem 287: 25749-25757
7. Li L, Millar AH and Shaobai Huang (2017)Mitochondrial Lon1 has a role in homeostasis of the mitochondrial ribosome and pentatricopeptide repeat proteins in plants. Plant Signaling&Behavior 12(2): e**
8. Solheim C,Li L, Hatzopoulos P, Millar AH (2012) Loss of Lon1 in Arabidopsis changes the mitochondrial proteome leading to altered metabolite profiles and growth retardation without an accumulation of oxidative damage. Plant Physiol 160: 1187-1203
9. Huang S, Nelson CJ,Li L, Taylor NL, Stroher E, Peteriet J, Millar AH (2015) INTERMEDIATE CLEAVAGE PEPTIDASE55 Modifies Enzyme Amino Termini and Alters Protein Stability in Arabidopsis Mitochondria. Plant Physiol 168: 415-427
10. Huang S, Jacoby RP, Shingaki-Wells RN,Li L, Millar AH (2013) Differential induction of mitochondrial machinery by light intensity correlates with changes in respiratory metabolism and photorespiration in rice leaves. New Phytol 198: 103-115
11. Jacoby RP,Li L, Huang S, Lee CP, Millar AH, Taylor NL (2012) Mitochondrial Composition, Function and Stress Response in Plants. J Integr Plant Biol 54(11): 887-906
12. Nelson CJ, Li L, Jacoby RP, Millar AH (2013) Degradation rate of mitochondrial proteins in Arabidopsis thaliana cells. J Proteome Res 12: 3449-3459
13.Nelson CJ,Li L, Millar AH(2013) Quantitative analysis of protein turnover in plants. Proteomics 12: 3449-3459
14.Simmons LW, Beveridge M, Li L, Tan YF, Millar AH (2014) Ontogenetic changes in seminal fluid gene expression and the protein composition of cricket seminal fluid. Evolution & Development 16: 101-109




社会兼职
中国植物生理与植物分子生物学学会（CSPB）理事
天津市植物生理与分子生物学学会（TSPB）秘书长



教学经历



荣誉称号
南开大学“百青计划”