马克.巴特兰姆



招生专业： 生物化学与分子生物学
电话： 无

邮箱： bartlam@nankai.edu.cn
办公地点： 天津市南开区卫津路94号南开大学药化生国重楼402







个人资料
性别： 男
部门： 生物化学与分子生物学系
联系电话： 无
通讯地址： 天津市南开区卫津路94号南开大学药化生国重楼402
职称： 教授
电子邮箱： bartlam@nankai.edu.cn
办公地址： 天津市南开区卫津路94号南开大学药化生国重楼402


教育经历
1995.9–1999.12, 牛津大学, 生物物理, 博士, 导师: David Stuart1992.9–1995.8, 帝国理工大学, 物理, 学士, 导师: Raymond Rivers

工作经历
2007.10-至今, 南开大学, 生命科学学院, 教授2003.9-2007.9, 清华大学, 生命科学学院, 副教授2000.1-2003.8, 清华大学, 生命科学学院, 外籍专家


个人简介
Mark Bartlam (马克.巴特兰姆)，博士生导师。1995年于英国帝国理工大学取得学士学位，1999年于英国牛津大学取得博士学位。Bartlam教授一直从事与重要人类疾病相关的蛋白质结构与功能，以及新型药物创制的研究。至今已解析140余个蛋白晶体结构，在Nature，Cell，PNAS，PLoS Biology, EMBO Journal，Nature Structural & Molecular Biology等国际顶尖级学术杂志上发表SCI论文140余篇，单篇引用率600余次。 Bartlam教授为外专局认证的外籍专家，2010年获天津市海河友谊奖、教育部新世纪优秀人才，2011年获得中国国家友谊奖，天津市国际科学技术合作奖。现兼任生物物理学会理事会理事及秘书会委员。担任《Scientific Reports》等国际知名期刊编委。主持并参与国家“973”，“863”，重大专项，国家基金委面上项目，天津市重点项目，欧盟第六框架(EU-FP6)，中英联合项目（Wellcome Trust, Royal Society）等多项国内以及国际合作科研项目。


研究方向
研究方向：与病毒和致病菌相关的蛋白质结构与功能；与肿瘤相关的蛋白质结构与功能；基于蛋白质结构的新型药物设计。



科研成果
1.Che S., Chen Y., Liang Y., Zhang Q., Bartlam M. Crystal structure of RecR, a member of the RecFOR DNA-repair pathway, from Pseudomonas aeruginosa PAO1. (2018) Acta Crystallographica Section:F Structural Biology Communications, 74, pp. 222-230.
2. Wu, Z., Xie, M., Li, Y., Gao, G., Bartlam, M., Wang, Y. Biodegradation of decabromodiphenyl ether (BDE 209) by a newly isolated bacterium from an e-waste recycling area (2018) AMB Express, 8 (1), 27.
3. Wu, Z., Bartlam, M., Wang, Y.Complete genome sequence of Stenotrophomonas sp. strain WZN-1, which is capable of degrading polybrominated diphenyl ethers (2017) Genome Announcements, 5 (31), e00722-17.
4. Li, S., Teng, X., Su, L., Mao, G., Xu, Y., Li, T., Liu, R., Zhang, Q., Wang, Y., Bartlam, M. Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1 (2017) FEBS Letters, 591 (12), pp. 1785-1797.
5. Xu, J., Wang, M., Sun, X., Ren, Q., Cao, X., Li, S., Su, G., Tuerhong, M., Lee, D., Ohizumi, Y., Bartlam, M., Guo, Y. Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS (2016) Journal of Natural Products, 79 (11), pp. 2924-2932.
6. Han, T., Zhao, Z., Bartlam, M., Wang, Y. Combination of biochar amendment and phytoremediation for hydrocarbon removal in petroleum-contaminated soil (2016) Environmental Science and Pollution Research, 23 (21), pp. 21219-21228.
7. Ji, Y., Postis, V.L.G., Wang, Y., Bartlam, M., Goldman, A. Transport mechanism of a glutamate transporter homologue GltPh (2016) Biochemical Society Transactions, 44 (3), pp. 898-904.
8. Hao, Z., Thomsen, M., Postis, V.L.G., Lesiuk, A., Sharples, D., Wang, Y., Bartlam, M., Goldman, A. A novel and fast purification method for nucleoside transporters (2016) Frontiers in Molecular Biosciences, 3 (JUN), 23.
9.Xu, J., Sun, X., Liu, X., Peng, M., Li, S., Jin, D.-Q., Lee, D., Bartlam, M., Guo, Y. Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells (2016) Journal of Functional Foods, 23, pp. 565-572.
10. Liu, J., Hao, Z., Ma, L., Ji, Y., Bartlam, M., Wang, Y. Spatio-temporal variations of high and low nucleic acid content bacteria in an exorheic river
(2016) PLoS ONE, 11 (4), e**.
11. Zhang, Q., Yan, D., Guo, E., Ding, B., Yang, W., Liu, R., Yamamoto, T., Bartlam, M. Structural basis for inhibition of the deadenylase activity of human CNOT6L (2016) FEBS Letters, 590 (8), pp. 1270-1279.
12. Ma, L., Mao, G., Liu, J., Gao, G., Zou, C., Bartlam, M.G., Wang, Y.
Spatial-temporal changes of bacterioplankton community along an exhorheic river (2016) Frontiers in Microbiology, 7 (MAR), 论文编号250, .
13. Ma, D., Hao, Z., Sun, R.,Bartlam, M., Wang, Y. Genome sequence of a typical ultramicrobacterium, Curvibacter sp. strain PAE-UM, capable of phthalate ester degradation (2016) Genome Announcements, 4 (1), e01510-15.
14. Zhang, A., Guo, E., Qian, L., Tang, N.-Y., Watt, R.M., Bartlam, M. Purification, crystallization and X-ray crystallographic analysis of a putative exopolyphosphatase from Zymomonas mobilis(2016) Acta Crystallographica Section:F Structural Biology Communications, 72, pp. 172-178.
15. Bai, Y., Tashiro, S., Nagatoishi, S., Suzuki, T., Yan, D., Liu, R., Tsumoto, K., Bartlam, M., Yamamoto, T. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach (2015) Protein and Cell, 6 (12), pp. 924-928.
16. Xie, C., Sun, L., Liao, K., Liu, S., Wang, M., Xu, J., Bartlam, M., Guo, Y.
Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi (2015) Journal of Natural Products, 78 (11), pp. 2800-2807.
17. Li, S., Li, T., Xu, Y., Zhang, Q., Zhang, W., Che, S., Liu, R., Wang, Y., Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 (2015) Scientific Reports, 5, 16915.
18. Ma, C., Hao, Z., Huysmans, G., Lesiuk, A., Bullough, P., Wang, Y., Bartlam, M., Phillips, S.E., Young, J.D., Goldman, A., Baldwin, S.A., Postis, V.L.G. A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters (2015) PLoS ONE, 10 (11), e**.
19.Xie, C., Wang, H., Sun, X., Meng, L., Wang, M.,Bartlam, M., Guo, Y.
Isolation, Characterization, and Antiproliferative Activities of Eudesmanolide Derivatives from the Flowers of Inula japonica (2015) Journal of Agricultural and Food Chemistry, 63 (41), pp. 9006-9011.
20. Liu, J., Yu, Y., Cai, Z., Bartlam, M., Wang, Y. Comparison of ITS and 18S rDNA for estimating fungal diversity using PCR–DGGE (2015) World Journal of Microbiology and Biotechnology, 31 (9), pp. 1387-1395.
21. Xie, C., Sun, L., Meng, L., Wang, M., Xu, J., Bartlam, M., Guo, Y. Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism (2015) Bioorganic and Medicinal Chemistry Letters, 25 (22), pp. 5409-5411.
22. Xu, K., Li, S., Yang, W., Li, K., Bai, Y., Xu, Y., Jin, J., Wang, Y., Bartlam, M.
Structural and biochemical analysis of tyrosine phosphatase related to biofilm formation A (TpbA) from the opportunistic pathogen pseudomonas aeruginosa PAO1 (2015) PLoS ONE, 10 (4), 论文编号e**, .
23. Liu, J., Wang, J., Gao, G., Bartlam, M.G., Wang, Y. Distribution and diversity of fungi in freshwater sediments on a river catchment scale
(2015) Frontiers in Microbiology, 6 (APR), 329.
24. Zheng, Q., Jiang, D., Zhang, W., Zhang, Q., Zhao, Q., Jin, J., Li, X., Yang, H., Bartlam, M., Shaw, N., Zhou, W., Rao, Z. Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase (2014) Journal of Biological Chemistry, 289 (31), pp. 21242-21251.
25. Xu, K., Bai, Y., Zhang, A., Zhang, Q., Bartlam, M.G.Insights into the structure and architecture of the CCR4-NOT complex (2014) Frontiers in Genetics, 5 (MAY), 137.
26. Jiang, D., Zhang, Q., Zheng, Q., Zhou, H., Jin, J., Zhou, W., Bartlam, M., Rao, Z. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine (2014) FEBS Journal, 281 (1), pp. 331-341.
27. Li, P., Xu, Y., Li, X., Bartlam, M. Crystallization and preliminary X-ray crystallographic analysis of the human CKIP-1 pleckstrin homology domain
(2013) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (3), pp. 324-327.
28. Ji, Y., Mao, G., Wang, Y., Bartlam, M. Crystallization and preliminary X-ray characterization of an NAD(P)-dependent butanol dehydrogenase A from Geobacillus thermodenitrificans NG80-2 (2013) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (2), pp. 184-187.
29. Hao, Z., Li, L., Liu, J., Ren, Y., Wang, L., Bartlam, M., Egli, T., Wang, Y.
Genome sequence of a freshwater low-nucleic-acid-content bacterium, betaproteobacterium strain CB (2013) Genome Announcements, 1 (2), e00135-13.
30. Bell, S.G., Yang, W., Yorke, J.A., Zhou, W., Wang, H., Harmer, J., Copley, R., Zhang, A., Zhou, R., Bartlam, M., Rao, Z., Wong, L.-L. Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: An aromatic hydrocarbon-binding P450 enzyme (2012) Acta Crystallographica Section D: Biological Crystallography, 68 (3), pp. 277-291.
31. Zhang, W., Fu, S., Liu, X., Zhao, X., Zhang, W., Peng, W., Wu, C., Li, Y., Li, X.,Bartlam, M., Zeng, Z.-H., Zhan, Q., Rao, Z. Erratum to: Crystal structure of human Gadd45γ reveals an active dimer (2012) Protein and Cell, 3 (3), p. 239.
32. Yang, W., Chen, W.-Y., Wang, H., Ho, J.W.S., Huang, J.-D., Woo, P.C.Y., Lau, S.K.P., Yuen, K.-Y., Zhang, Q., Zhou, W., Bartlam, M., Watt, R.M., Rao, Z.
Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis (2011) Nucleic Acids Research, 39 (22), pp. 9803-9819.
33. Whitehouse, C.J.C., Yang, W., Yorke, J.A., Tufton, H.G., Ogilvie, L.C.I., Bell, S.G., Zhou, W., Bartlam, M., Rao, Z., Wong, L.-L. Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450 BM3) variant (2011) Dalton Transactions, 40 (40), pp. 10383-10396.
34. Zhang, W., Peng, W., Zhao, M., Lin, D., Zeng, Z., Zhou, W., Bartlam, M.
Expression, purification and preliminary crystallographic analysis of human thyroid hormone responsive protein (2011) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67 (8), pp. 941-946.
35. Yu, J., Li, X., Wang, Y., Li, B., Li, H., Li, Y., Zhou, W., Zhang, C., Wang, Y., Rao, Z., Bartlam, M., Cao, Y. PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza a virus NS1 (2011) PLoS ONE, 6 (5), e19511 .
36. Lu, K., Li, P., Zhang, M., Xing, G., Li, X., Zhou, W., Bartlam, M., Zhang, L., Rao, Z., He, F. Pivotal role of the C2 domain of the smurf1 ubiquitin ligase in substrate selection (2011) Journal of Biological Chemistry, 286 (19), pp. 16861-16870.
37. Hou, H., Wang, F., Zhang, W., Wang, D., Li, X., Bartlam, M., Yao, X., Rao, Z. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response (2011) Journal of Biological Chemistry, 286 (11), pp. 9623-9635.
38. Yang, W., Bell, S.G., Wang, H., Zhou, W., Bartlam, M., Wong, L.-L., Rao, Z.
The structure of CYP101D2 unveils a potential path for substrate entry into the active site (2011) Biochemical Journal, 433 (1), pp. 85-93.
39. Ma, M., Bell, S.G., Yang, W., Hao, Y., Rees, N.H., Bartlam, M., Zhou, W., Wong, L.-L., Rao, Z. Structural analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444 (2011) ChemBioChem, 12 (1), pp. 88-99.
40. Zhang, W., Fu, S., Liu, X., Zhao, X., Zhang, W., Peng, W., Wu, C., Li, Y., Li, X., Bartlam, M., Zeng, Z.-H., Zhan, Q., Rao, Z. Crystal structure of human Gadd45 reveals an active dimer (2011) Protein and Cell, 2 (10), pp. 814-826.
41. Whitehouse, C.J.C., Yang, W., Yorke, J.A., Rowlatt, B.C., Strong, A.J.F., Blanford, C.F., Bell, S.G., Bartlam, M., Wong, L.-L., Rao, Z. Structural basis for the properties of two single-site proline mutants of CYP102A1 (P450BM3) (2010) ChemBioChem, 11 (18), pp. 2549-2556.
42. Yang, W., Li, K., Bai, Y., Zhou, R., Zhou, W., Bartlam, M. Expression, purification, crystallization and preliminary crystallographic analysis of PA3885 (TpbA) from Pseudomonas aeruginosa PAO1 (2010) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (11), pp. 1473-1476.
43. Huo, Y., Hu, Z., Zhang, K., Wang, L., Zhai, Y., Zhou, Q., Lander, G., Zhu, J., He, Y., Pang, X., Xu, W., Bartlam, M., Dong, Z., Sun, F. Crystal structure of group II chaperonin in the open state (2010) Structure, 18 (10), pp. 1270-1279.
44. Yang, W., Bell, S.G., Wang, H., Zhou, W., Hoskins, N., Dale, A., Bartlam, M., Wong, L.-L., Rao, Z. Molecular characterization of a class I P450 electron transfer system from Novosphingobium aromaticivorans DSM12444 (2010) Journal of Biological Chemistry, 285 (35), pp. 27372-27384.
45. Wang, H., Morita, M., Yang, X., Suzuki, T., Yang, W., Wang, J., Ito, K., Wang, Q., Zhao, C., Bartlam, M., Yamamoto, T., Rao, Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity (2010) EMBO Journal, 29 (15), pp. 2566-2576.
46. Xue, F., Sun, Y., Yan, L., Zhao, C., Chen, J., Bartlam, M., Li, X., Lou, Z., Rao, Z. The crystal structure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1β reveals a novel metal-dependent nuclease
(2010) Journal of Virology, 84 (13), pp. 6461-6471.
47. Feng, X., Bell, S.G., Ying, P., Johnson, E.O.D., Bartlam, M., Rao, Z., Luet-Lok, W. Erratum: Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris (2010) Proteins: Structure, Function and Bioinformatics, 78 (2), p. 501.
48. Liao, S., Tung, E.T.K., Zheng, W., Chong, K., Xu, Y., Dai, P., Guo, Y., Bartlam, M., Yuen, K.-Y., Rao, Z. Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein (2010) Journal of Biological Chemistry, 285 (12), pp. 9211-9220.
49. Djordjevic, S., Zhang, X., Bartlam, M., Ye, S., Rao, Z., Danpure, C.J. Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting (2010) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (3), pp. 233-236.
50. Bell, S.G., Xu, F., Johnson, E.O.D., Forward, I.M., Bartlam, M., Rao, Z., Wong, L.-L. Protein recognition in ferredoxin-P450 electron transfer in the class i CYP199A2 system from Rhodopseudomonas palustris (2010) Journal of Biological Inorganic Chemistry, 15 (3), pp. 315-328.
51. Zhang, C., Wu, Y., Sun, Y., Hong, C., Xiang, K., Guo, Y., Bartlam, M., Lou, Z.
A novel non-radioactive assay for HIV-RT (RdDp) based on pyrosequencing for high-throughput drug screening (2010) Protein and Cell, 1 (3), pp. 284-290.
52. Zhou, X., Lou, Z., Fu, S., Yang, A., Shen, H., Li, Z., Feng, Y., Bartlam, M., Wang, H., Rao, Z. Crystal structure of argp from mycobacterium tuberculosis confirms two distinct conformations of full-length lysr transcriptional regulators and reveals its function in dna binding and transcriptional regulation (2010) Journal of Molecular Biology, 396 (4), pp. 1012-1024.
53. Bartlam, M., Yamamoto, T. The structural basis for deadenylation by the CCR4-NOT complex (2010) Protein and Cell, 1 (5), pp. 443-452.
54. Li, S., Zhao, Q., Zhang, Y., Zhang, Y., Bartlam, M., Li, X., Rao, Z. New nsp8 isoform suggests mechanism for tuning viral RNA synthesis (2010) Protein and Cell, 1 (2), pp. 198-204.
55. Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z. Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity (2010) FASEB Journal, 24 (1), pp. 242-252.
56. Zhao, X., Pang, H., Wang, S., Zhou, W., Yang, K., Bartlam, M. Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein (2010) Protein and Cell, 1 (8), pp. 771-779.
57. Wu, Y., Lou, Z., Miao, Y., Yu, Y., Dong, H., Peng, W., Bartlam, M., Li, X., Rao, Z. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China (2010) Protein and Cell, 1 (5), pp. 491-500.
58. Xu, F., Bell, S.G., Peng, Y., Johnson, E.O.D., Bartlam, M., Rao, Z., Wong, L.-L. Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris (2009) Proteins: Structure, Function and Bioinformatics, 77 (4), pp. 867-880.
59. Wang, B., Yang, L.-P., Zhang, X.-Z., Huang, S.-Q., Bartlam, M., Zhou, S.-F. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme Structural features of CYP2D6 B. (2009) Drug Metabolism Reviews, 41 (4), pp. 573-643.
60. Tian, X., Lu, G., Gao, F., Peng, H., Feng, Y., Ma, G., Bartlam, M., Tian, K., Yan, J., Hilgenfeld, R., Gao, G.F. Structure and Cleavage Specificity of the Chymotrypsin-Like Serine Protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) (2009) Journal of Molecular Biology, 392 (4), pp. 977-993.
61. Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Zhang, L., Chen, S., Li, X., Liu, Y., Bartlam, M., Rao, Z. Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center (2009) Journal of Virology, 83 (18), pp. 9024-9030.
62. Cao, Y., Lou, Z., Sun, Y., Xue, F., Feng, C., Gong, X., Yang, D., Bartlam, M., Meng, Z., Zhang, K. Crystallization and preliminary X-ray characterization of a PaaX-like protein from Sulfolobus solfataricus P2 (2009) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65 (8), pp. 776-778.
63. Wang, X., Lou, Z., Dong, X., Yang, W., Peng, Y., Yin, B., Gong, Y., Yuan, J., Zhou, W., Bartlam, M., Peng, X., Rao, Z. Crystal Structure of the C-Terminal Domain of Human DPY-30-Like Protein: A Component of the Histone Methyltransferase Complex (2009) Journal of Molecular Biology, 390 (3), pp. 530-537.
64. Xu, X., Lou, Z., Ma, Y., Chen, X., Yang, Z., Tong, X., Zhao, Q., Xu, Y., Deng, H., Bartlam, M., Rao, Z. Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59
(2009) PLoS ONE, 4 (7), e6217.
65. Whitehouse, C.J.C., Bell, S.G., Yang, W., Yorke, J.A., Blanford, C.F., Strong, A.J.F., Morse, E.J., Bartlam, M., Rao, Z., Wong, L.-L. A highly active single-mutation variant of P450BM3 (CYP102A1) (2009) ChemBioChem, 10 (10), pp. 1654-1656.
66. Wu, L., Wang, L., Hua, G., Liu, K., Yang, X., Zhai, Y.,Bartlam, M., Sun, F., Fan, Z. Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M (2009) Journal of Immunology, 183 (1), pp. 421-429.
67. Zhang, W., Wang, L., Liu, Y., Xu, J., Zhu, G., Cang, H., Li, X., Bartlam, M., Hensley, K., Li, G., Rao, Z., Zhang, X.C. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione (2009) Genes and Development, 23 (12), pp. 1387-1392.
68. Liu, Y., Lou, Z., Bartlam, M., Rao, Z. Structure-function studies of the influenza virus RNA polymerase PA subunit (2009) Science in China, Series C: Life Sciences, 52 (5), pp. 450-458.
69. Yuan, P., Bartlam, M., Lou, Z., Chen, S., Zhou, J., He, X., Lv, Z., Ge, R., Li, X., Deng, T., Fodor, E., Rao, Z., Liu, Y. Crystal structure of an avian influenza polymerase PA N reveals an endonuclease active site (2009) Nature, 458 (7240), pp. 909-913.
70. Hong, C., Bell, S.G., Yang, W., Wang, H., Hao, Y., Li, X., Zhou, W., Bartlam, M., Wong, L.-L. Purification, crystallization and preliminary X-ray analysis of cytochrome P450 219A1 from novosphingobium aromaticivorans DSM 12444
(2009) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65 (4), pp. 364-367.
71. Meng, Z., Liu, Z., Lou, Z., Gong, X., Cao, Y., Bartlam, M., Zhang, K., Rao, Z. Purification, characterization and crystallization of pyrroline-5-carboxylate reductase from the hyperthermophilic archeon Sulfolobus Solfataricus (2009) Protein Expression and Purification, 64 (2), pp. 125-130.
72. Dong, H., Lou, Z., Xu, X., Su, D., Zhou, X., Li, X., Bartlam, M. Crystallization and preliminary crystallographic analysis of recombinant human calcyphosine (2009) Protein and Peptide Letters, 16 (3), pp. 339-341.
73. Xu, Y., Cong, L., Chen, C., Wei, L., Zhao, Q., Xu, X., Ma, Y., Bartlam, M., Rao, Z. Crystal structures of two coronavirus ADP-ribose-1″-monophosphatases and their complexes with ADP-ribose: A systematic structural analysis of the viral ADRP domain (2009) Journal of Virology, 83 (2), pp. 1083-1092.
74. Yang, X., Morita, M., Wang, H., Suzuki, T., Yang, W., Luo, Y., Zhao, C., Yu, Y., Bartlam, M., Yamamoto, T., Rao, Z. Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity (2008) Nucleic Acids Research, 36 (21), pp. 6872-6881.
75. Bell, S.G., Xu, F., Forward, I., Bartlam, M., Rao, Z., Wong, L.-L. Crystal Structure of CYP199A2, a Para-Substituted Benzoic Acid Oxidizing Cytochrome P450 from Rhodopseudomonas palustris (2008) Journal of Molecular Biology, 383 (3), pp. 561-574.
76. Dong, H., Li, X., Lou, Z., Xu, X., Su, D., Zhou, X., Zhou, W., Bartlam, M., Rao, Z. Crystal-Structure and Biochemical Characterization of Recombinant Human Calcyphosine Delineates a Novel EF-Hand-Containing Protein Family
(2008) Journal of Molecular Biology, 383 (3), pp. 455-464.
77. Zhao, X., Wang, S., Pang, H., Yang, K., Bartlam, M. Crystallization and preliminary X-ray diffraction studies of the calcium-binding protein CalD from Streptomyces coelicolor (2008) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64 (9), pp. 816-818.
78. Zhao, Q., Li, S., Xue, F., Zou, Y., Chen, C., Bartlam, M., Rao, Z.
Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1 (2008) Journal of Virology, 82 (17), pp. 8647-8655.
79. He, X., Zhou, J., Bartlam, M., Zhang, R., Ma, J., Lou, Z., Li, X., Li, J., Joachimiak, A., Zeng, Z., Ge, R., Rao, Z., Liu, Y. Crystal structure of the polymerase PAC-PB1N complex from an avian influenza H5N1 virus (2008) Nature, 454 (7208), pp. 1123-1126.
80. Li, X., Lou, Z., Li, X., Zhou, W., Ma, M., Cao, Y., Geng, Y., Bartlam, M., Zhang, X.C., Rao, Z. Structure of human cytosolic X-prolyl aminopeptidase: A double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit (2008) Journal of Biological Chemistry, 283 (33), pp. 22858-22866.
81. Zhang, R., Zhu, G., Zhang, W., Cao, S., Ou, X., Li, X., Bartlam, M., Xu, Y., Zhang, X.C., Rao, Z. Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity (2008) Protein Science, 17 (8), pp. 1412-1423.
82. Guo, D., Xu, F., Bell, S.G., Pang, X., Bartlam, M., Wong, L.-L. Purification, crystallization and preliminary crystallographic analysis of CYP 195A2, a P450 enzyme from Rhodopseudomonas palustris (2008) Protein and Peptide Letters, 15 (4), pp. 423-426.
83. Li, M., Li, S., Lou, Z., Liao, X., Zhao, X., Meng, Z., Bartlam, M., Rao, Z. Crystal structure of human transgelin (2008) Journal of Structural Biology, 162 (2), pp. 229-236.
84. Xue, X., Yu, H., Yang, H., Xue, F., Wu, Z., Shen, W., Li, J., Zhou, Z., Ding, Y., Zhao, Q., Zhang, X.C., Liao, M., Bartlam, M., Rao, Z. Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design (2008) Journal of Virology, 82 (5), pp. 2515-2527.
85. Li, L., Liu, X., Yang, W., Xu, F., Wang, W., Feng, L., Bartlam, M., Wang, L., Rao, Z. Crystal Structure of Long-Chain Alkane Monooxygenase (LadA) in Complex with Coenzyme FMN: Unveiling the Long-Chain Alkane Hydroxylase
(2008) Journal of Molecular Biology, 376 (2), pp. 453-465.
86. Bartlam, M., Xue, X., Rao, Z. The search for a structural basis for therapeutic intervention against the SARS coronavirus (2008) Acta Crystallographica Section A: Foundations of Crystallography, 64 (1), pp. 204-213.
87. Bartlam, M., Xu, Y., Rao, Z. Structural proteomics of the SARS coronavirus: A model response to emerging infectious diseases (2007) Journal of Structural and Functional Genomics, 8 (2-3), pp. 85-97.
88. Li, Z., Huang, Y., Ge, J., Fan, H., Zhou, X., Li, S., Bartlam, M., Wang, H., Rao, Z. The Crystal Structure of MCAT from Mycobacterium tuberculosis Reveals Three New Catalytic Models (2007) Journal of Molecular Biology, 371 (4), pp. 1075-1083.
89. Wu, B., Liu, Y., Zhao, Q., Liao, S., Zhang, J., Bartlam, M., Chen, W., Rao, Z.
Crystal Structure of RS21-C6, Involved in Nucleoside Triphosphate Pyrophosphohydrolysis (2007) Journal of Molecular Biology, 367 (5), pp. 1405-1412.
90. Zheng, W., Sun, F., Bartlam, M., Li, X., Li, R., Rao, Z. The Crystal Structure of Human Isopentenyl Diphosphate Isomerase at 1.7 ? Resolution Reveals its Catalytic Mechanism in Isoprenoid Biosynthesis (2007) Journal of Molecular Biology, 366 (5), pp. 1447-1458.
91. Huo, X., Su, D., Wang, A., Zhai, Y., Xu, J., Li, X., Bartlam, M., Sun, F., Rao, Z. Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart (2007) FEBS Journal, 274 (6), pp. 1524-1529.
92. Xue, X., Yang, H., Shen, W., Zhao, Q., Li, J., Yang, K., Chen, C., Jin, Y., Bartlam, M., Rao, Z. Production of Authentic SARS-CoV Mpro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction (2007) Journal of Molecular Biology, 366 (3), pp. 965-975.
93. Liao, X., Li, S., Lou, Z., Chen, Z., Bartlam, M. Crystallization and preliminary crystallographic analysis of transgelin (2007) Protein and Peptide Letters, 14 (2), pp. 209-211.
94. Zhao, Q., Qin, L., Jiang, F., Wu, B., Yue, W., Xu, F., Rong, Z., Yuan, H., Xie, X., Gao, Y., Bai, C., Bartlam, M., Pei, X., Rao, Z. Structure of human spindlin1: Tandem tudor-like domains for cell cycle regulation (2007) Journal of Biological Chemistry, 282 (1), pp. 647-656.
95. Ye, S., Wu, X., Wei, L., Tang, D., Sun, P., Bartlam, M., Rao, Z. An insight into the mechanism of human cysteine dioxygenase: Key roles of the thioether-bonded tyrosine-cysteine cofactor (2007) Journal of Biological Chemistry, 282 (5), pp. 3391-3402.
96. Li, J., Shen, W., Liao, M., Bartlam, M. Preliminary crystallographic analysis of avian infectious bronchitis virus main protease (2007) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 63 (1), pp. 24-26.
97. Yang, H., Bartlam, M., Rao, Z. Drug design targeting the main protease, the Achilles' heel of coronaviruses (2006) Current Pharmaceutical Design, 12 (35), pp. 4573-4590.
98. Lou, Z., Xu, Y., Xiang, K., Su, N., Qin, L., Li, X., Gao, G.F.,Bartlam, M., Rao, Z. Crystal structures of Nipah and Hendra virus fusion core proteins (2006) FEBS Journal, 273 (19), pp. 4538-4547.
99. Li, X., Chen, Y., Liu, Y., Gao, J., Gao, F., Bartlam, M., Wu, J.Y., Rao, Z. Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway (2006) Journal of Biological Chemistry, 281 (38), pp. 28430-28437.
100. Meng, Z., Lou, Z., Liu, Z., Hui, D., Bartlam, M., Rao, Z. Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase (2006) Protein Expression and Purification, 49 (1), pp. 83-87.
101. Li, S., Liao, X., Chen, Z., Bartlam, M. Crystallization and preliminary crystallographic analysis of allograft inflammatory factor (2006) Protein and Peptide Letters, 13 (8), pp. 855-858.
102. Su, D., Lou, Z., Sun, F., Zhai, Y., Yang, H., Zhang, R., Joachimiak, A., Zhang, X.C., Bartlam, M., Rao, Z. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10 (2006) Journal of Virology, 80 (16), pp. 7902-7908.
103. Xu, X., Zhai, Y., Sun, F., Lou, Z., Su, D., Xu, Y., Zhang, R., Joachimiak, A., Zhang, X.C., Bartlam, M., Rao, Z. New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15 (2006) Journal of Virology, 80 (16), pp. 7909-7917.
104. Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. Crystal Structure of Human Pyrroline-5-carboxylate Reductase (2006) Journal of Molecular Biology, 359 (5), pp. 1364-1377.
105. Liang, W., Yang, H., Xue, X., Huang, Q., Bartlam, M., Chen, S. Expression, crystallization and preliminary X-ray studies of the immunoglobulin-like domain 3 of human paladin (2006) Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (6), pp. 556-558.
106. Ou, X., Ji, C., Han, X., Zhao, X., Li, X., Mao, Y., Wong, L.-L.,Bartlam, M., Rao, Z. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1) (2006) Journal of Molecular Biology, 357 (3), pp. 858-869.
107. Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z.
Crystal structure of the N-terminal SH3 domain of mouse βPIX, p21-activated kinase-interacting exchange factor (2006) Biochemical and Biophysical Research Communications, 339 (1), pp. 407-414.
108. Bartlam, M., Yang, H., Rao, Z. Structural insights into SARS coronavirus proteins (2005) Current Opinion in Structural Biology, 15 (6), pp. 664-672.
109. Zhai, Y., Sun, F., Li, X., Pang, H., Xu, X., Bartlam, M., Rao, Z. Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer (2005) Nature Structural and Molecular Biology, 12 (11), pp. 980-986.
110. Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Zhao, Q., Zhou, Z., Pei, D., Ziebuhr, J., Hilgenfeld, R., Kwok, Y.Y., Wong, L., Gao, G., Chen, S., Chen, Z., Ma, D., Bartlam, M., Rao, Z. Erratum: Design of wide-spectrum inhibitors targeting coronavirus main proteases (2005) PLoS Biology, 3 (11), e428, p. 2044.
111. Dong, Y.-J., Bartlam, M., Sun, L., Zhou, Y.-F., Zhang, Z.-P., Zhang, C.-G., Rao, Z., Zhang, X.-E. Crystal structure of methyl parathion hydrolase from Pseudomonas sp. WBC-3 (2005) Journal of Molecular Biology, 353 (3), pp. 655-663.
112. Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Zhao, Q., Zhou, Z., Pei, D., Ziebuhr, J., Hilgenfeld, R., Kwok, Y.Y., Wong, L., Gao, G., Chen, S., Chen, Z., Ma, D., Bartlam, M., Rao, Z. Design of wide-spectrum inhibitors targeting coronavirus main proteases (2005) PLoS Biology, 3 (10), e324, pp. 11P.
113. Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M., Rao, Z.
Crystal structure of mitochondrial respiratory membrane protein Complex II (2005) Cell, 121 (7), pp. 1043-1057.
114. Ng, J.D., Bartlam, M. Acta Crystallographica Section D: Biological Crystallography: Preface (2005) Acta Crystallographica Section D: Biological Crystallography, 61 (6), pp. i.
115. Wang, H., Pang, H., Bartlam, M., Rao, Z. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity (2005) Journal of Molecular Biology, 348 (4), pp. 917-926.
116. Sun, L., Bartlam, M., Liu, Y., Pang, H., Rao, Z. Crystal structure of the pyridoxal-5′-phosphate-dependent serine dehydratase from human liver (2005) Protein Science, 14 (3), pp. 791-798.
117. Han, X., Bartlam, M., Jin, Y.-H., Liu, X., He, X., Cai, X., Xie, Q., Rao, Z.
The expression of SARS-CoV M gene in P. Pastoris and the diagnostic utility of the expression product (2004) Journal of Virological Methods, 122 (1), pp. 105-111.
118. Pang, H., Liu, Y., Han, X., Xu, Y., Jiang, F., Wu, D., Kong, X., Bartlam, M., Rao, Z. Protective humoral responses to severe acute respiratory syndrome-associated coronavirus: Implications for the design of an effective protein-based vaccine (2004) Journal of General Virology, 85 (10), pp. 3109-3113.
119. Bartlam, M., Wang, G., Yang, H., Gao, R., Zhao, X., Xie, G., Cao, S., Feng, Y., Rao, Z. Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 (2004) Structure, 12 (8), pp. 1481-1488.
120. Wu, B., Li, P., Liu, Y., Ding, Y., Shu, C., Ye, S., Bartlam, M., Shen, B., Rao, Z. 3D structure of human FK506-binding protein 52: Implication for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (22), pp. 8348-8353.
121. Liu, B., Li, X., Gao, R., Zhou, W., Xie, G., Bartlam, M., Pang, H., Feng, Y., Rao, Z. Crystallization and preliminary X-ray analysis of inorganic pyrophosphatase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3 (2004) Acta Crystallographica Section D: Biological Crystallography, 60 (3), pp. 577-579.
122. Shi, N., Ye, S., Bartlam, M., Yang, M., Wu, J., Liu, Y., Sun, F., Han, X., Peng, X., Qiang, B., Yuan, J., Rao, Z. Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain (2004) Journal of Biological Chemistry, 279 (6), pp. 4962-4969.
123. Pang, H., Bartlam, M., Zeng, Q., Miyatake, H., Hisano, T., Miki, K., Wong, L.-L., Gao, G.F., Rao, Z. Crystal structure of human pirin: An iron-binding nuclear protein and transcription cofactor (2004) Journal of Biological Chemistry, 279 (2), pp. 1491-1498.
124. Liu, B., Bartlam, M., Gao, R., Zhou, W., Pang, H., Liu, Y., Feng, Y., Rao, Z.
Crystal Structure of the Hyperthermophilic Inorganic Pyrophosphatase from the Archaeon Pyrococcus horikoshii (2004) Biophysical Journal, 86 (1 I), pp. 420-427.
125. Wang, G., Guo, R., Bartlam, M., Yang, H., Xue, H., Liu, Y., Huang, L., Rao, Z. Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii (2003) Protein Science, 12 (12), pp. 2815-2822.
126. Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L., Ye, S., Pang, H., Gao, G.F., Anand, K., Bartlam, M., Hilgenfeld, R., Rao, Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (23), pp. 13190-13195.
127. Zhang, X., Roe, S.M., Hou, Y., Bartlam, M., Rao, Z., Pearl, L.H., Danpure, C.J. Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1 (2003) Journal of Molecular Biology, 331 (3), pp. 643-652.
128. Zeng, Q., Li, X., Bartlam, M., Wang, G., Pang, H., Rao, Z. Purification, crystallization and preliminary X-ray analysis of human pirin (2003) Acta Crystallographica - Section D Biological Crystallography, 59 (8), pp. 1496-1498.
129. Ding, Y., Jiang, W., Zhang, S., Mao, X., Bartlam, M., Zhao, G., Rao, Z.
Crystallographic studies of cephalosporin acylase from pseudomonas sp. strain 130 (2003) Tsinghua Science and Technology, 8 (4), pp. 395-401.
130. Guo, Q., Zhou, W., Too, H.-M., Li, J., Liu, Y., Bartlam, M., Dong, Y., Wong, K.-B., Shaw, P.-C., Rao, Z. Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants (2003) Protein Engineering, 16 (6), pp. 391-396.
131. Ding, Y., Too, H., Wang, Z., Liu, Y., Bartlam, M., Dong, Y., Wong, K., Shaw, P., Rao, Z. The structural basis of Trp192 and the C-terminal region in trichosanthin for activity and conformational stability (2003) Protein Engineering, 16 (5), pp. 351-356.
132. He, H., Ding, Y., Bartlam, M., Sun, F., Le, Y., Qin, X., Tang, H., Zhang, R., Joachimiak, A., Liu, J., Zhao, N., Rao, Z. Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for β-lactam acetylation (2003) Journal of Molecular Biology, 325 (5), pp. 1019-1030.
133. Sun, F., Li, P., Ding, Y., Wang, L., Bartlam, M., Shu, C., Shen, B., Jiang, H., Li, S., Rao, Z. Design and Structure-Based Study of New Potential FKBP12 Inhibitors (2003) Biophysical Journal, 85 (5), pp. 3194-3201.
134. Shi, N., Zhou, W., Tang, K., Gao, Y., Jin, J., Gao, F., Peng, X., Bartlam, M., Qiang, B., Yuan, J., Rao, Z. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein (2002) Acta Crystallographica Section D: Biological Crystallography, 58 (12), pp. 2170-2172.
135. Jin, J., Chen, X., Zhou, Y., Bartlam, M., Guo, Q., Liu, Y., Sun, Y., Gao, Y., Ye, S., Li, G., Rao, Z., Qiang, B., Yuan, J. Crystal structure of the catalytic domain of a human thioredoxin-like protein: Implications for substrate specificity and a novel regulation mechanism (2002) European Journal of Biochemistry, 269 (8), pp. 2060-2068.
136. Chen, Y., Song, G., Jiang, F., Feng, L., Zhang, X., Ding, Y., Bartlam, M., Yang, A., Ma, X., Ye, S., Liu, Y., Tang, H., Song, H., Rao, Z. Crystal structure of a staphylokinase variant: A model for reduced antigenicity (2002) European Journal of Biochemistry, 269 (2), pp. 705-711.
137. Chen, Y., Shao, R., Bartlam, M., Li, J., Jin, L., Gao, Y., Liu, Y., Tang, H., Zhen, Y., Rao, Z. Crystallization and preliminary X-ray crystallographic studies of a macromolecular antitumour antibiotic, C1027 (2002) Acta Crystallographica Section D: Biological Crystallography, 58 (1), pp. 173-175.
138. Zhang, H., Wang, Z., Ding, Y., Wang, G., Wang, X., Bartlam, M., Tang, H., Liu, Y., Jiang, F., Barraclough, R., Rudland, P.S., Rao, Z. Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4 (2002) Acta Crystallographica Section D: Biological Crystallography, 58 (1), pp. 127-129.
139. Wang, G., Guo, R., Bartlam, M., Xue, H., Yang, H., Liu, Y., Huang, L., Rao, Z. Expression, purification, crystallization and preliminary X-ray analysis of a DNA-binding protein from Methanococcus jannaschii (2002) Acta Crystallographica Section D: Biological Crystallography, 58 (7), pp. 1240-1242.
140. Lin, W., Zhao, Q., Bartlam, M., Ding, Y., Li, D., Chen, Y., Bao, H., Xie, Q., Rao, Z. Purification, crystallization and X-ray analysis of swine vesicular disease virus (2002) Acta Crystallographica Section D: Biological Crystallography, 58 (6 II), pp. 1056-1058.
141. Yu, M., Wang, E., Liu, Y., Cao, D., Jin, N., Zhang, C.W.-H., Bartlam, M., Rao, Z., Tien, P., Gao, G.F. Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of newcastle disease virus (2002) Journal of General Virology, 83 (3), pp. 623-629.
142. He, H., Ding, Y., Cao, Z., Shao, Y., Bartlam, M., Tang, H., Jiang, F., Liu, Y., Liu, J., Zhao, N., Rao, Z. Crystallization and preliminary X-ray crystallographic analysis of native and selenomethionyl recombinant tabtoxin-resistance protein complexed with acetyl-coenzyme A (2001) Acta Crystallographica Section D: Biological Crystallography, 57 (11), pp. 1729-1731.
143. Wang, Z., Zhang, H., Ding, Y., Wang, G., Wang, X., Ye, S., Bartlam, M., Tang, H., Liu, Y., Jiang, F., Barraclough, R., Rudland, P.S., Rao, Z. Preliminary X-ray crystallographic analysis of a Ca2+-binding protein human S100A1
(2001) Acta Crystallographica Section D: Biological Crystallography, 57 (6), pp. 882-883.
144. Sunde, M., Serpell, L.C., Bartlam, M., Fraser, P.E., Pepys, M.B., Blake, C.C.F. Common core structure of amyloid fibrils by synchrotron X-ray diffraction (1997) Journal of Molecular Biology, 273 (3), pp. 729-739.



社会兼职
2016年至今，《Scientific Reports》期刊编辑。
2012年至今，英国利兹大学客座教授。



教学经历
本科生课程《英文科技论文写作》 (2013年至今）
研究生课程《英文科技论文写作》（2009年至今）
研究生课程《结构生物学导论》（2010年至2014年）



荣誉称号
2017年2016“外教中国”年度人物
2014年天津市创新人才推进计划中青年科技创新领军人才
2012年天津市国际科学技术合作奖
2011年北京市科学技术奖
2011年中华人民共和国国家友谊奖
2010年天津市海河友谊奖
2010年教育部新世纪优秀人才