姓名：李宗金
职称：教授

一、教育经历
博士后斯坦福大学 2005-2009
博士中国协和医科大学 2000-2005
学士白求恩医科大学 1989-1994

二、工作经历
2009-至今南开大学医学院
2005-2009 斯坦福大学放射系，分子影像中心

三、研究方向
干细胞治疗与分子影像学：1）在应用胚胎干细胞、心脏干细胞、内皮细胞用于缺血性疾病的治疗; 2) 干细胞联合生物材料在再生医学中的应用；3) 干细胞治疗在大动物，如猪、猴子的临床前期评价；4)分子影像在干细胞治疗中的应用等。
在研项目：
1) 国家重大科学研究计划项目973（项目编号：2011CB964903） 2011-2015
研究课题“多潜能干细胞特异性诱导分化及其表观遗传学调控在治疗糖尿病中的应用基础研究”，子课题“在体胰岛组织和肾上皮组织干细胞归巢、复制、分化的示踪新技术与新方法”。2) 天津应用基础与前沿技术研究计划（自然科学基金）重点项目 (项目批准号：12JCZDJC24900) 2012-2014
3) 国家教育部留学回国人员科研启动金: 2012/01-2014/12
4) 2012年度教育部“新世纪优秀人才支持计划” 2013-1-2015-12
干细胞示踪新技术与新方法的应用基础研究
5) 国家自然科学基金 （项目批准号：**） 2014-2017
人胚胎干细胞(hESC)移植治疗心肌梗死机理的多模态分子影像学研究
6) 国家自然科学基金重点项目（项目批准号：**） 2014-2017
间充质干细胞移植治疗心肌梗死的报告基因PET与MRI活体分子成像

四、学术兼职
2010-至今 自然科学基金面上项目评审
2010-2012 Associate Editorial Board Member, American Journal of Nuclear Medicine and Molecular Imaging
2010-2015 Editorial Board Member of World Journal of Stem Cells
2012-2014 中国组织工程研究杂志执行编委
2012- 高等学校博士学科点专项科研基金网络评审专家
2012- 教育部学位中心“省市优秀硕士学位论文评选”通讯评议评审专家
2012- 第四军医大学消化系肿瘤研究协同创新中心兼职教授
2012- 天津医学表观遗传学协同创新中心兼职教授
2013- 国家科学技术奖励评审专家

五、发表论文(共发表论文50余篇)
(第一作者/*通讯作者论文)
1. Zhao Q, Tong L, Wang Y, Su W, Xiang R, Li Z*. IFN-? mediate graft-versus-breast cancer effects via enhancing cytotoxic T lymphocytes activation. 2014, Exp Ther Med, 2014, in press
2. Ningning He, Lu Zhang, Jian Cui, Zongjin Li*. Bone Marrow Vascular Niche: Home for Hematopoietic Stem Cells (HSCs). 2014, Bone Marrow Research, 2014, in press.
3. Liang Leng, Yuebing Wang, Ningning He, Di Wang, Qianjie Zhao, Guowei Feng, Weijun Su, Yang Xu, Zhongchao Han, Deling Kong, Zhen Cheng, Rong Xiang, Zongjin Li*. Molecular Imaging for Assessment of Mesenchymal Stem Cells Mediated Breast Cancer Therapy. Biomaterials, 2014, DOI: 10.1016/j.biomaterials.2014.03.014 in press (IF, 7.6)
4. Wang L, Wang Y, Li, Z*. Advances in Nanoparticle-Based Tumor Theranostics with Molecular Imaging. Curr Pharm Biotech, 2013, 14(7): 683-92. PMID **
5. Feng G, Mao D, Che Y, Su W, Wang Y, Xu Y, Fan Y, Zhao H, Kong D, Xu Y, Li Z*. The Phenotypic Fate for Bone Marrow-Derived Stem Cells in Acute Kidney Injury. Cellular Phys Biochem, 2013, 32:1517-1527 (IF, 3.4)
6. Su W, Wang L, Zhou M, Tong L, Liu Z, Hu S, Liu F, Liu Y, Yan F, Kong D, Han Z, Wu JC, Xiang R, Li Z*. Human Embryonic Stem Cell-derived Endothelial Cells as Cellular Delivery Vehicles for Targeting Therapy of Breast Cancer. Cell Transplant. 2013;22(11):2079-90. PMID: ** (IF, 4.4)
7. Xiaohua Jia, Xiaoqiang Xie, Guowei Feng, He Lü, Qinjun Zhao, Yongzhe Che, Yizhou Zheng, Zhongchao Han, Yong Xu*, Zongjin Li*, Deling Kong. Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury. BMC Nephrology. 2012, 13:105. PMID:** (IF, 2.2)
8. Xiaohua Jia, He Lü, Jie Li, Guowei Feng, Yongzhe Che, Zhongchao Han, Yong Xu, Zongjin Li*, Deling Kong*. Human Embryonic Stem Cells-Derived Endothelial Cell Therapy Facilitates Kidney Regeneration by Stimulating Renal Resident Stem Cell Proliferation in Acute Kidney Injury. Chinese Science Bulletin. 2013, 58(23): 2812-19. (IF, 1.32)
9. Manqian Zhou, Lina Wang, Weijun Su, Lingling Tong, Ze Liu, Yanghua Liu, Fan Yan, Na Luo, Yizhou Zheng, Hui Zhao, Rong Xiang*, Zongjin Li*. Assessment of Therapeutic Efficacy of Liposomal Nanoparticles Mediated Gene Delivery by Molecular Imaging for Cancer Therapy. J Biomed Nanotechnol. 2012, 8(5): 742-750. PMID: ** (IF, 4.2)
10. Lina Wang , Weijun Su, Ze Liu, Manqian Zhou, Si Chen, Yanan Chen, Dan Lu, Yanhua Liu, Fan Yan, Yizhou Zheng, Zhongchao Han, Deling Kong, Joseph C. Wu, Rong Xiang*, Zongjin Li*. CD44 Antibody Targeted Liposomes for Molecular Imaging and Therapy of Hepatocellular Carcinoma. Biomaterials. 2012, 33(20): 5107-5114. PMID: ** (IF, 7.6)
11. Guowei Feng, Jian Cui, Yizhou Zheng, Zhongchao Han, Yong Xu*, Zongjin Li*. Identification, Characterization and Biological Significance of Very Small Embryonic-Like Stem Cells (VSELs) in Regenerative Medicine. Histol Histopathol. 2012, 27(7): 827-833. PMID: ** (IF, 2.5)
12. Zongjin Li, Shijun Hu, Zhumur Ghosh, Zhongchao Han, and Joseph C. Wu. Functional Characterization and Expression Profiling of Human Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Endothelial Cells. Stem Cell Dev. 2011, 20(10): 1701-1710. PMID: ** (IF, 4.5)
13. Weijun Su, Manqian Zhou, Yizhou Zheng, Yan Fan, Lina Wang, Zhongchao Han, Deling Kong, Robert Chunhua Zhao, Joseph C. Wu, Rong Xiang*, Zongjin Li*. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. J Cell Biochem. 2011, 112: 840–848. PMID: ** (IF, 3.06)
14. Yajie Wang, Yanming Wang, Lin Wang, Yongzhe Che, Zongjin Li*, Deling Kong*. Preparation and evaluation of magnetic nanoparticles for cell labeling. J Nanosci Nanotech. 2011, 11: 3749-3756. PMID: ** (IF, 1.6)
15. Zongjin Li, Kitchener D. Wilson, Bryan Smith, Daniel L. Kraft, Fangjun Jia, Mei Huang, Xiaoyan Xie, Robert C. Robbins, Sanjiv S. Gambhir, Irving L. Weissman, Joseph C. Wu. Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction. PLoS ONE. 2009, 4(12): e8443. PMID: ** (IF, 4.1)
16. Zongjin Li, Andrew Lee, Mei Huang, Hyung Chun, Jaehoon Chung, Pauline Chu, Grant Hoyt, Phillip Yang, Jarrett Rosenberg, Robert C. Robbins, and Joseph C. Wu. Imaging Survival and Function of Transplanted Cardiac Stem Cells. J Am Coll Cardiol. 2009, 53(14): 1229-40. PMID:** (IF,14.2)
17. Zongjin Li*, Zhongchao Han, Joseph C. Wu*. Transplantation of Human Embryonic Stem Cell-Derived Endothelial Cells for Vascular Diseases. J Cell Biochem. 2009, 106:194-199. PMID: ** (Journal cover, invited review) (IF, 2.8)
18. Kitchener D. Wilson#, Zongjin Li#, Roger Wagner, Patrick Yue, Phillip Tsao, Gergana Nestorova, Mei Huang, David L. Hirschberg, Paul G. Yock, Thomas Quertermous, Joseph C. Wu. Transcriptome alteration in the diabetic heart by rosiglitazone: Implications for cardiovascular mortality. PLoS ONE. 2008, 3(7): e2609. PMID: ** (#Co-first author) (IF, 4.1)
19. Zongjin Li, Yoriyasu Suzuki, Mei Huang, Feng Cao, Xiaoyan Xie, Andrew J. Connolly, Phillip C. Yang, Joseph C. W. Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Stem Cells. 2008, 26(4): 864-873. PMID: ** (IF, 7.9)
20. Zongjin Li, Jenny C. Wu, Ahmad Y. Sheikh, Daniel Kraft, Feng Cao, Xiaoyan Xie, Manishkumar Patel, Sanjiv S. Gambhir, Robert C. Robbins, John P. Cooke, and Joseph C. Wu. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation.2007; 116: I46-I54. PMID: ** (IF, 14.8)
21. Zong Jin Li, Zack Z. Wang, Yi Zhou Zheng, Bin Xu, Ren Chi Yang, David T. Scadden, Zhong Chao Han. Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation. J Cell Biochem. 2005; 95(3): 559-570. PMID: ** (IF, 3.06)


(参与论文)
22. Fang Fang, Scott M. Wasserman, Jesus Torres-Vazquez, Brant Weinstein, Feng Cao, Zongjin Li, Kitchener D. Wilson, Wen Yue, Joseph C. Wu, Xiaoyan Xie, and Xuetao Pei. The role of Hath6, a novel shear stress-responsive transcription factor, in endothelial differentiation and function modulation. J Cell Sci. 2014. In press (IF, 5.88)
23. Yi Liu, Xiaoying Ye, Lina Mao, Zhaokang Cheng, Xinpeng Yao, Xiaohua Jia, Duo Mao, Lailiang Ou, Zongjin Li, Yongzhe Che, Na Liu, Gustav Steinhoff, Lin Liu, Deling Kong. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction. Cardiovascular Research. 2013, 97(2):208-18. PMID: ** (IF, 6.1)
24. Dan Lu, Si Chen, Xiaoyue Tan, Na Li, Chenghu Liu, Zongjin Li, Ze Liu, Dwayne G Stupack, Ralph A. Reisfeld, and Rong Xiang. Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy. Cancer Res, 2012, 72(14): 3451-6. PMID:** (IF, 7.8)
25. Shijun Hu, Mei Huang, Patricia K. Nguyen, Yongquan Gong, Zongjin Li, Fangjun Jia, Feng Lan, Junwei Liu, Divya Nag, Robert C. Robbins, and Joseph C. Wu. Novel MicroRNA Pro-survival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation. Circulation. 2011, 124: S27-S34. PMID: ** (IF, 15.2) (Top 3 advances in AHA Basic Cardiovascular Sciences in 2011)
26. Shijun Hu, Mei Huang, Zongjin Li, Fangjun Jia, Zhumur Ghosh, Maarten A. Lijkwan, Pasquale Fasanaro, Ning Sun, Xi Wang, Fabio Martelli, Robert C. Robbins, and Joseph C. Wu. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation. 2010, 122:S124-S131. PMID: ** (IF, 14.8)
27. Kitchener D. Wilson, Ning Sun, Mei Huang, Wendy Y. Zhang, Andrew S. Lee, Zongjin Li, Shan X. Wang, and Joseph C. Wu. Effects of Ionizing Radiation on Self Renewal and Pluripotency of Human Embryonic Stem Cells. Cancer Res. 2010, 70(13): 5539-48. PMID: ** (IF, 7.8)
28. Ngan F. Huang, Hiroshi Niiyama, Christoph Peter, Abhijit De, Yasodha Natkunam, Felix Fleissner, Zongjin Li, Mark D. Rollins, Joseph C. Wu, Sanjiv S. Gambhir, and John P. Cooke. Embryonic Stem Cell-Derived Endothelial Cells Incorporate into the Ischemic Hindlimb and Restore Perfusion. Arterioscl Throm Vas. 2010, 30:915-922. PMID: ** (IF, 6.5)
29. Fangjun Jia, Kitchener D Wilson, Ning Sun, Deepak M Gupta, Mei Huang, Zongjin Li, Nicholas J Panetta, Zhi Ying Chen, Robert C Robbins, Mark A Kay, Michael T Longaker & Joseph C Wu. A Simple Non-viral Minicircle Vector for Deriving Human iPS Cells. Nature Methods. 2010, 7(3): 197-199. PMID: ** (IF, 23.5)
30. Marcel M. Daadi, Alexis S. Davis, Ahmet Arac, Zongjin Li, Anne-Lise Maag, Rishi Bhatnagar, Kewen Jiang, Guohua Sun, Joseph C. Wu, and Gary K. Steinberg. Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting In Neonatal Hypoxic-Ischemic Brain Injury. Stroke. 2010, 41(3): 516-23. PMID: ** (IF, 5.7) (selected by F1000)
31. Mei Huang, ZhiYing Chen, Shijun Hu, Fangjun Jia, Zongjin Li, Grant Hoyt, Robert C. Robbins, Mark A. Kay, and Joseph C. Wu. Novel minicircle vector for cell based gene therapy in murine myocardial infarction. Circulation. 2009, 120:S230-S237. PMID: ** (IF, 15.2)
32. Marcel M Daadi, Zongjin Li, Ahmet Arac, Brad A Grueter, Marc Sofilos, Robert C Malenka, Joseph C Wu and Gary K Steinberg. Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell-Derived Neural Stem Cell Grafts in Ischemic Rat Brain. Molecular Therapy. 2009, 17(7): 1282–1291. PMID: ** (IF, 6.9)
33. Mei Huang, Denise A. Chan, Fangjun Jia, Xiaoyan Xie, Zongjin Li, Grant Hoyt, Robert C. Robbins, Xiaoyuan Chen, Amato J. Giaccia, and Joseph C. Wu. Short Hairpin RNA Interference Therapy for Ischemic Heart Disease. Circulation.2008; 118: s226-233. PMID: ** (IF, 15.2)

六、讲授课程
1．病理生理学(七年制)
2．干细胞生物学(硕士、博士)

七、荣誉和奖励
2006 美国心脏学会(AHA)墙报前10名
2006-2007 斯坦福大学博士后基金
2007 美国血管生物学会Jay D. Coffman优秀青年科学家奖
2008 第57届美国心脏病学会(ACC)优秀青年科学家奖
2008 ACCF/Bristol-Myers Squibb Travel Award, 美国心脏病学会(ACC)
2008 斯坦福大学医学院心血管病研究所，优秀青年科学家奖
2008 国际干细胞学会 (ISSCR) Travel Award
2008 Mitzi and William Blahd, MD 启动基金第一名, 美国核医学会
2009 Journal of Cellular Biochemistry, 2009年106卷第2期封面文章
2010 发表在 Stroke, 2010, 41(3):516-23 的文章被F1000选中.
2012 南开大学第四届良师益友提名奖
2012 教育部“新世纪优秀人才支持计划”

八、联系方式
1．通讯地址：天津市南开区卫津路94号
2．电话：022-2350 9332
3．E-mail：zongjinli@nankai.edu.cn
4．网页：www.zongjinlab.com， http://www.researcherid.com/rid/G-3118-2010