姓名：张竹君
职称：副教授

一、教育经历
例：1999.4-2004.3 神户大学医学院儿科，医学博士学位
1990.9-1995.7 中国医科大学临床医学专业，医学学士学位

二、工作经历
例：2008.11至今 南开大学医学院，副教授
2004.4-2008.10 日本神户大学医学院儿科，博士后


三、研究方向
1．研究领域：遗传病的分子诊断和分子治疗的研究:
(1) 开发快速分子诊断方法。
(2) 研究微小突变对splicing的影响及机理。
(3) 应用人工合成反义寡聚核苷酸治疗Duchenne型肌营养不良。

2．科研项目：承担一项国家自然科学基金面上项目，项目编号：**

四、近5年论文

1. Takeshima Y, Yagi M, Okizuka Y, Awano H, Zhang Z, Yamauchi Y, Nishio H, Matsuo M. Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center. J Hum Genet 2010; 55 (6): 379-88.
2. Zhang Z, Yagi M, Okizuka Y, Awano H, Takeshima Y, Matsuo M. Insertion of IL1RAPL1 gene into the duplication junction of the dystrophin gene. J Hum Genet 2009; 54(8): 466-73.
3. Nishiyama A, Takeshima Y, Zhang Z, Habara Y, Tran TH, Yagi M, Matsuo M. Dystrophin nonsense mutations can generate alternative rescue transcripts in lymphocytes. Ann Hum Genet 2008; 72: 717-24.
4. Zhang Z, Takeshima Y, Awano H, Nishiyama A, Okizuka Y, Yagi M, Matsuo M. Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy. J Hum Genet 2008; 53(3):215-9.
5. Sahashi K, Masuda A, Matsuura T, Shinmi J, Zhang Z, Takeshima Y, Matsuo M, Sobue G, Ohno K . In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites. Nucleic Acids Res 2007; 35(18):5995-6003.
6. Zhang Z, Yasuaki Habara, Atsushi Nishiyama, Yoshinobu Oyazato, Mariko Yagi, Yasuhiro Takeshima and Masafumi Matsuo. Identification of seven novel cryptic exons embedded in the dystrophin gene and characterization of 14 cryptic dystrophin exons. J Hum Genet 2007; 52(7):607-17.
7. Tran VK, Takeshima Y, Zhang Z, Habara Y, Haginoya K, Nishiyama N, Yagi M and Matsuo M. A nonsense mutation-created intraexonic splice site is active in the lymphocytes, but not in the skeletal muscle of a DMD patient. Human Genet 2007; 120(5): 737-42.
8. Tran VK, Takeshima Y, Zhang Z, Yagi M, Nishiyama N, Habara Y and Matsuo M. Splicing analysis disclosed a determinant single nucleotide for exon skipping caused by a novel intra-exonic four-nucleotide deletion in the dystrophin gene. J Med Genet 2006; 43(12): 924-30.



五、讲授课程
1． 七年制临床医学专业病理学
2． 五年制口腔医学专业病理学
3． 三年制研究生病理学技术

六、联系方式
1． 通讯地址：天津市南开区卫津路94号，南开大学医学院，邮编：300071
2． 电话：
3． E-mail：zhang_zhujun@nankai.edu.cn