姓名：刘菲菲
职称：副教授

一 教育经历:
2008 – 2011 博士后，美国哈佛大学医学院, MGH麻省总医院
2002 - 2007 免疫学博士, 美国杜克大学
2002 – 2007 细胞分子生物学专业，美国杜克大学
1995 – 2002 七年制临床医学本硕连读，南开大学，医学院

二 工作经历:
2011.11 至今 南开大学 医学院 副教授
2008 – 2011 博士后，哈佛大学医学院，麻省总医院，波士顿
2004 – 2007 博士研究生,杜克大学医学中心，免疫系，北卡罗来纳州

三 研究方向
研究领域为Ikaros基因在T淋巴细胞发育和急性淋巴细胞白血病的控制机制。 Ikaros基因编码调控早期造血系和淋巴系的转录因子。 DNA结合区域缺陷的Ikaros小鼠缺乏T，B和自然杀伤细胞，并且缺乏早期淋巴系前体干细胞。因此Ikaros调控全能造血干细胞向淋巴系分化。研究在基因敲除小鼠中, 确定Ikaros基因敲除导致transitional 过渡T细胞的分化和增殖，在第三期中产生急性T淋巴细胞白血病并有Notch1高表达，并运用Chip-seq和基因芯片进行三期T淋巴细胞的表观遗传信息和基因转录表达。

1. T lymphocyte commitment and differentiation
2. role of chromatin binding protein in the regulation of gene expression and epigenetics
3. molecular mechanism of leukemic development

科研项目：?
项目负责人：
? 国家自然科学基金青年基金：B细胞骨髓免疫耐受机制－抗原非依赖性IgH和Igkappa 的V(D)J基因重排（23万，2013-2015）
? 南开大学校内基金特别资助类：Ikaros调控急性T淋巴细胞白血病的功能 (50万，2012－2014)

四 论文:
1. Feifei Liu, Pablo Gómez-del Arco, Katia Georgopoulos. Role of Ikaros in controlling lymphoblastic leukemia during T-cell development. (manuscript preparation)

2. Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie & Katia Georgopoulos. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nature Immunology. 2011 Nov. 13;13(1):86-94 (impact factor 26; Fourth author)

3. Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo and Katia Georgopoulos. Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis. Immunity. 2010 Nov; Vol. 33(5) p. 685 – 698. (impact factor 24.2; Fourth author)

4. Feifei Liu, Masayuki Kuraoka, Lindsay G. Cowell, Emily Heikamp, Garnett Kelsoe. Spontaneous secondary Ig? rearrangements during B-cell development: Implication in receptor editing. Journal of Experimental Medicine (submitted)

5. Marco Davila*, Feifei Liu*, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, Garnett Kelsoe. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro-B cells. Journal of Experimental Medicine. 2007 Dec 24; Vol. 204, p3195-3208. (* co-first author) (sci impact factor 15.61)

6. Feifei Liu, Ying Hu, Wei Ge, Robert Chunhua Zhao. Biological characteristics and multiple differentiation pathways of human embryonic stem cells. Shanxi Medical Journal. 2002, Vol. 31, p524-527.

五 荣誉和奖励:
2006 - 2007 Duke Conference Travel Fellowship, Duke University
2006 Bernard Amos Research Award
2006 Certificate for professionalism and academic excellence
The Graduate School, Duke University

六 专业协会:
American Association of Immunologists (AAI)
American Association for the Advancement of Science (AAAS)
Member of the Leukemia & Lymphoma Society

七 讲授课程
医学免疫学

八 联系方式
1 通讯地址：天津市南开区卫津路94号 南开大学医学院 101办公室
2 E-mail：liufeifei@nankai.edu.cn