姓名：Dwayne G. Stupack

职称：南开大学讲座教授

一、教育经历

1984-1988 本科B.Sc.(Hons), Genetics遗传学

University of Manitoba (Fort Garry), Faculty of Science,

Winnipeg, Canada

1990 – 1996 研究生Graduate Student to Ph.D微生物

Health Sciences Centre, Rheumatic Diseases Unit Laboratory

Dr. John A. Wilkins. (University of Manitoba, Bannatyne)

二、工作经历

2011-current Associate Professor of Reproductive Medicine (tenured)

The University of California San Diego, Dept of Pathology,

The Moores Comprehensive Cancer Center, Section of Gynecological

Oncology

2005- 2010 Assistant Professor to Associate Professor of Pathology

The University of California San Diego, Dept of Pathology & MCC

The Moores Comprehensive Cancer Center

2002-2005 Senior Research Associate (to Assistant Professor 2005)

The Scripps Research Institute, Dept. of Immunology.

1996-2001 Research Associate

The Scripps Research Institute, Dept. of Immunology.

Dr. David A. Cheresh’s Laboratory

三、研究方向

研究主要集中在理解干预机制以预防肿瘤转移，南开大学的研究将会集中于干细胞的全能性，以及细胞粘附和相关的信号通路。

项目：

序 号

项目名称

项目性质及来源

项目经费

起始年度

终止年度

排

序
1

Integrins and Caspase 8 in Tumor Progression

美国NIH 基金项目

$1,415,000

2010

2015

1
2

RTS-SCA. Real Time Secretion: Secreted Cell Anabolites

美国国家科学基金项目

$180,000

2012

2015

1
3

Integrins and Caspase 8 in Tumor Progression

美国NIH 基金项目

$91,500

2009

2010

1
4

Nine Girls Ask Foundation Grants in Aid

Private Foundation Grant私人基金会的资助



$50,000

2014

2015

1
5

Nine Girls Ask Foundation Grants in Aid

Private Foundation Grant私人基金会的资助



$50,000

2012

2013

1
6

Center of Nanotechonology for Treatment, Understanding, and Monitoring of Cancer

美国NIH 基金项目

$21,627,310

2005

2010


7

Integrins and Caspase 8 in neuroblastoma Progression

美国NIH 基金项目

$1,500,000

2004

2009

1
8

Planning Grant for In Vivo Cellular and Molecular Imaging Centers (ICMICs)

美国NIH 基金项目

$7,500,000

2007

2012


9

Rho- and GPCR-mediated signaling through cellular effectors

美国NIH 基金项目

$1,250,000

2007

2012


10

Preclinical testing of a focal adhesion kinase inhibitor

Poniard (Industrial Grant) （工业项目）



$400,000

2008

2009

1

四、学术兼职

Reviewer: Nation/Agency:

USA: CDMRP (Breast Cancer, CBY5, 2010)

NIH-NCI (TCB CSR Study section, 2007, ad hoc, ARRA 2009),

NIH-NIAIDS (ZRG series Special Review Panel, 2008, 2009),

NIH-NCI (TME CSR Study section, 2011 ),

Leukemia and Lymphoma Society Career Development Panel

American Cancer Society (Grants in Aid, San Diego Chapter)

Foundation for Melanoma Research,

Canada: Heritage Foundation

France: ARC(Associatione Recherche de Cancre),ANR(Association

Nationale de Recherche)

Singapore: Medical Research Council,

Qatar: Qatar National Research Fund

Professional Review（专业评审）

CDMRP Breast Cancer Review Panel CBY5 2010

NIH (NCI & NIAID) reviewer (Ad Hoc) 2007-2009, 2011-2014

NIH (NCI) TME Study section 2013-2017

五、近五年论文

1. Cheresh, D.A. and Stupack, D.G*. Regulation of angiogenesis: apoptotic cues from the ECM. Oncogene, 27:6285-6298, 2008.

2. Barbero, S., Barila, D., Mielgo A., Clair, K, Stagni, V., and Stupack D.G.* Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem. 283:13031-13035, 2008. ^{Featured Article in the Journal}

3. Wrasidlo, D.G., Mielgo, A., Torres, V. Barbero, S., Stolenov, K., Gerwick, W., Carson, D., and D.G. Stupack*. The marine lipopeptide Somocystinamide A triggers apoptosis via caspase 8. Proc Nat Acad Sci USA 105;2313-2318, 2008.

4. Torres, V.A., Mielgo,A., Barila, D., Anderson, D.H. and D.G. Stupack*. Caspase 8 promotes peripheral localization and activation of Rab5. J. Biol. Chem. 283:36280-36289, 2008.^{Featured Article in the Journal}

5. Barbero, S., Mielgo, A., Torres, V., Teitz, T, Shields, D.J., Mikolon D., Bogyo., M., Barila, D., Lahti., J.M., Schlaepfer, D., and Stupack., D.G*. Caspase 8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res. 69:3755-3763, 2009.

6. Mielgo, A., Torres, V.A., Barbero, S., and Stupack, D.G*. Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules. Oncogene, doi: 10.1038/onc.2009.210, 2009.

7. Mielgo, A., Torres, V.A., Schmid, M.C., Graf, R., Zeitlin, S.G., Lee., P., Shields, D.J., , Barbero, S., Jamora, C., and Stupack, D.G.* The death effector domains of caspase-8 induce terminal differentiation. PloS One, doi:10.1371/journal.pone.**, 2009.

8. Torres, V.A., Mielgo, A., Barbero, S., Hsiao, R., Wilkins, J.A. Stupack D.G*. Rab5 Mediates Caspase-8 Promoted Cell Motility and Metastasis. Mol Biol Cell, 21:369-376 2010^{*Editor’s choice/nominee for paper of the year in MBoC.}

9. Walsh, C., Tanjoni, I., Uryu, S., Tomar, A., Nam, J-O., Luo, H., Phillips, A., Patel, N., Kwok, C., McMahon, G., Stupack, D.G*., and Schlaepfer D.D.* Oral Delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther 9:778-790, 2010. ^{* Stupack and Schlaepfer are ‘co-senior’ authors on this manuscript.}

10. Tanjoni, I., Walsh, C., Uryu, S., Tomar, A., Nam, J-O., Mielgo A., Lim, S-T., Liang, C., Koenig, M., Patel, N., Kwok, C., McMahon, G., Stupack, D.G*., and Schlaepfer D.D.* PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther 9, 764-777, 2010. PMID: ** ^{* Stupack and Schlaepfer are ‘co-senior’ authors on this manuscript.}

11. Murphy, E., and Stupack, D.G*. Vitronectin binding integrins in cancer. In Cell-Extracellular Matrix Interactions in Cancer. Springer-Verlag., Eds. Zent, R., & Pozzi, A. 137-170, 2010 doi:10.1007/978-a-4419-0814-8_7.

12. Stupack, D.G. Caspase-8 as a therapeutic target in cancer. Cancer Lett epub ahead of print. PMID** 2010.

13. Torres V.A, Stupack, D.G*. Rab5 in the regulation of cell motility and invasion. Current Protein Pep Sci 12:43-51, 2011.

14. Yuan, R., Lio, J., Mielgo, A, Schmid, M. Stupack, D.G*. Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. Apoptosis 17:229-235, 2012.

15. Mendoza P, Ortiz R, Díaz J, Quest AF, Leyton L, Stupack DG, Torres VA. Rab5 Activation Promotes Focal Adhesion Disassembly, Migration and Invasiveness of Tumor Cells. J Cell Sci. 2013 Jun 26. [Epub ahead of print] PubMed PMID:**.

16. Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.G*.. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr. 2013 Jun 10;7(4). [Epub ahead of print] PubMed PMID: **

六、讲授课程

Molecules to Disease／从分子到疾病

Molecular and Cell Biology／分子和细胞生物学

Seminars in Pathology／病理学讲座

Methods in Molecular Pathology／分子病理学方法

Cell Biology／细胞生物学

Direct Study Research／直接学习研究

Oncology Block／原癌基因阻断

七、联系方式

The University of California San Diego, Dept of Pathology

Office Address: The Moores UCSD Cancer Center

3855 Heath Sciences Drive MC 0803

La Jolla, CA, 92093 803

Office Telephone: 858 822 1150

FAX: 858 822 1975



email: dstupack@ucsd.edu