姓名： 李玉皓
职称： 副教授

一、教育经历
1999.9-2002.7 天津医科大学，医学博士（眼科学专业）
1996.9-1999.7 天津医科大学，医学硕士（病理学专业）
1991.9-1996.7 天津医科大学，医学学士


二、工作经历
2007.04-今 南开大学医学院 天津市模式动物与退行性神经系统疾病重点实验室 副教授
2009.06-2010.10 美国密歇根大学（University of Michigan, Ann Arbor）Kellogg Eye Center 博士后


三、研究方向

以斑马鱼为动物模型，进行退行性神经系统疾病的分子遗传学及病理学研究。研究方向为：（1）利用转基因模型研究髓鞘脱失和髓鞘损伤的机制；（2）小胶质细胞在感光细胞发育及损伤再生中的调控机制；（3）纳米材料的活体成像及生物毒性。


四、近年发表的论文
1.Yangwu Fang, Xudan Lei, Xiang Li, Yanan Chen, Fei Xu, Xizeng Feng*, Shihui Wei*, Yuhao Li*. A novel model of demyelination and remyelination in a GFP-transgenic zebrafish. Biol Open, 2015; 4 (1): 62-68.
2.Yan-Fei Kang, Yu-Hao Li, Yang-Wu Fang, Yang Xu, Xiao-Mi Wei, Xue-Bo Yin. Carbon Quantum Dots for Zebrafish Fluorescence Imaging. Sci Rep, 2015; 5: 11835.
3.Qian-Qian Shi?, Yu-Hao Li?, Yang Xu, Yue Wang, Xue-Bo Yin*, Xi-Wen He, Yu-Kui Zhang. High-yield and high-solubility nitrogen-doped carbon dots: formation, fluorescence mechanism and imaging application. RSC Adv, 2014; 4: 1563-1566.
4.Yajie Wang?, Zizi He?, Yangwu Fang?, Yang Xu, Yanan Chen, Guanqun Wang, Yongqiang Yang, Zhuo Yang*, Yuhao Li*. The effect of titanium dioxide nanoparticles on zebrafish embryos and developing retina. Int J Ophthalmol, 2014; 7 (6): 917-923.
5.Yike Yuan, Yaguang Zhang, Shaohua Yao*, Huashan Shi, Xi Huang, Yuhao Li, Yuquan Wei, Shuo Lin. The translation initiation factor Eif3i upregulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis. J Biol Chem, 2014; 289 (41): 28310-28123.
6.Yang Xu, Yu-Hao Li, Yue Wang, Jian-Lin Cui, Xue-Bo Yin, Xi-Wen He, Yu-Kui Zhang. 13C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response. Analyst, 2014; 139 (20): 5134-5139.
7.Xiao-Mi Wei, Yang Xu, Yu-Hao Li, Xue-Bo Yin, Xi-Wen He. Ultrafast synthesis of nitrogen-doped carbon dots via neutralization heat for bioimaging and sensing applications. RSC Adv, 2014; 4: 44504-44508.
8.Yang Xi, Dongyan Chen, Lei Sun, Yuhao Li*, Lei Li*. Characterization of zebrafish mutants with defects in bone calcification during development. Biochem Biophys Res Commun, 2013; 440: 132-136.
9.Tao Huang, Jianlin Cui, Lei Li, Peter F. Hitchcock, Yuhao Li*. The role of microglia in the neurogenesis of zebrafish retina. Biochem Biophys Res Commun, 2012; 421: 214-220.
10.Jinping Shao, Dongyan Chen, Qijun Ye, Jianlin Cui, Yuhao Li, Lei Li*. Tissue regeneration after injury: A study of the caudal fin regenerative capacity in adult zebrafish. Dev Dyn, 2011, 240: 1271-1277.
11.Lei Li*, Yuhao Li, Dongyan Chen, Jinping Shao, Xinle Li, Chen Xu. Fishing for age-related visual system mutants: behavioral screening of retinal degeneration genes in zebrafish. Curr Aging Sci, 2010; 3(1): 43-45.
Zhuohan Zhang, Bin Zeng, Guohui Jiao, Yuhao Li, Yu Liu, Yuan Zhang, Rongcun Yang*. AA28-67 domain within MyD88 suppresses c-myc activity and expression to regulate differentiation and function of dendritic cells. Clin Immunol, 2009; 133: 324-332.


五、讲授课程
1. 口腔组织病理学
2. 病理学实验
3. 医学与人类健康

六、荣誉和奖励
1.《纳米氧化钛颗粒对斑马鱼胚胎和视网膜发育的作用》，第十三届“挑战杯”天津市大学生课外学术科技作品竞赛，特等奖，优秀指导教师，2015
2.《医学与人类健康》，大学素质教育优秀通选课，获奖人：李玉皓、刘文、张京玲、王德坤，中国高等教育学会大学素质教育研究分会，2014
3.天津市第九届青年教师基本功大赛，优秀奖，2008
南开大学青年教师基本功大赛，一等奖，2008

七、联系方式
1.通讯地址：天津市南开区卫津路94号，南开大学医学院
2. E-mail：liyuhao@nankai.edu.cn