吴卫辉
性 别：男
职 称：教授
所属部门：微生物学系
招生专业：微生物学
研究方向：微生物学

::教师简介::
个人简历1998南开大学 学士2001南开大学 硕士2006美国佛罗里达大学 博士2006--2009美国德克萨斯大学M.D.安德森癌症研究中心 博士后2009--2011美国哈佛大学医学院布雷根及妇女医院 博士后2011--南开大学生命科学学院教授1998B.S. Nankai University2001M.S. Nankai University2006Ph.D. University of Florida, USA2006--2009University of Texas M.D. Anderson Cancer Center, Postdoctoral Fellow 2009--2011Harvard Medical School Brigham and Women’s Hospital, Postdoctoral Fellow2011--Nankai University College of Life Sciences, Professor研究方向■ 致病菌毒性基因的表达调控及作用机制；■ 致病菌耐药机理研究；■ 宿主在感染过程中的免疫反应Research Fields■ Regulation and function of pathogenic bacterial virulence factors ■ Mechanisms of antibiotics resistance in pathogenic bacteria ■ Host immune responses during infectionSelected Publications■ Sun Z, Shi J, Liu C, Jin Y, Li K, Chen R, Jin S, Wu W. (2014) PrtR Homeostasis Contributes to Pseudomonas aeruginosa Pathogenesis and Resistance against Ciprofloxacin. Infection and Immunity. Feb 3. [Epub ahead of print]. （IF=4）■ Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W. (2013) SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa. MBio. Oct 29;4(6). doi:pii: e00419-13. 10.1128/mBio.00419-13. (IF=5.6)■ Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. (2012) Collaboration between macrophages and vaccine-induced CD4 T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. J Infect Dis. Oct 24.■ Wu W, Huang J, Duan B, Traficante DC, Hong H, Risech M, Lory S, Priebe GP. (2012) Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia.Am. J. Respir. Crit. Care Med. Sep 1;186(5):420-7.ss. (IF=10)■ Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 285(34):25969-77.■ Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14. (IF=25)■ Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. (2008) MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31..■ Yang, H., Z. Shan, J. Kim, W. Wu, W. Lian, L. Zeng, L. Xing and S. Jin. (2007) Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa. J Bacteriol. 189(7):2599-609■ Wu, W., Y. Song, S. Jin and S. Chen. (2006) An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10. ■ Jyot, J., A. Sonawane, W. Wu and R. Ramphal. (2007) Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38.■ Wu, W. and S. Jin. (2005) PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68.(IF=4)■ Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. (2004) MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85.(IF=4)联系方式: 办公电话 ** 电子邮件 wuweihui@nankai.edu.cn
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