个人简介：
李宏宝，副教授，硕/博士生导师。
主要研究方向为1. 肠道微生物与心血管疾病；2.心血管疾病的神经内分泌机制及治疗新靶点。目前主持国家自然科学基金青年项目1项、中国博士后面上项目2项、陕西省博士后基金1项、陕西省自然科学基金青年项目1项，教育部春晖计划项目1项，另参与国家自然科学基金重大研究计划项目、面上项目等多个科研项目。累计发表SCI论文36篇，其中以第一作者/通讯作者在Hypertension, Gut Microbes, Molecular Nutrition & Food Research等国际学术期刊上发表SCI收录论文12篇。中国生理学会会员。美国生理学会会员。任SCI杂志Cardiovascular Toxicology编委，中华高血压杂志青年编委等。同时长期担任Toxicology and Applied Pharmacology，Journal of functional foods, Cardiovascular Toxicology等SCI杂志审稿人。

研究领域（方向）：
1. 肠道微生物与心血管疾病；
2. 心血管疾病的神经内分泌机制及治疗新靶点。
教育与工作经历：
2012年获兰州大学生理学硕士学位。2015年毕业于西安交通大学医学院，获博士学位，并留校工作。2017-2018年在美国佛罗里达大学公派访学。2019/03-至今，西安交通大学，副教授/博导。

主持科研项目情况：
1. 国家自然科学基金项目，2018-01至2020-12, 在研，主持
2. 主持西安交通大学基本科研业务费，2020-01至2022年-12，主持
3. 中国博士后面上项目一等资助，2020-01至2021-12, 在研，主持
4. 教育部“春晖计划”合作科研项目，2020-01至2021-12, 在研，主持
5. 陕西省自然科学基金青年项目，2017-01至2018-12，已结题，主持
6. 中国博士后面上项目二等资助，2017-01至2018-12，已结题，主持
7. 陕西省博士后基金项目，2016-01至2017-12月，已结题，主持

近五年发表部分论文情况：本人通讯作者以*标出
1． Wen-Jie Xia, Meng-Lu Xu, Xiao-Jing Yu, Meng-Meng Du, Xu-Hui Li, Tao Yang, Lu Li, Qing Su, Jia-Xi Xu, Xiao-Lian Shi,Hong-Bao Li*(通讯作者), Yu-Ming Kang, Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat,Gut Microbes,2021, 13(1):1-24. IF: 7.74.
2． Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia,Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Altered gut microbiota is involved in the anti-hypertensive effects of Vitamin C in spontaneously hypertensive rat,Molecular Nutrition and Food Research, 2021, doi: 10.1002/mnfr.. IF: 5.309 (封面论文)
3． Ying Li*, Salman Zafar, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia,Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats,Life Sciences, 2021, 269:119097.
4． Hong-Bao Li,Tao Yang，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male Offspring，Hypertension, 2020, 75:1315-1324. IF: 7.713.
5． Hong-Bao Li, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang, Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus,International Journal of Cardiology, 2019, 280:142-151. IF: 3.229.
6． Hui Zhang,Hong-Bao Li (共同一作), Jian-Rui Lyu, Xiao-Ming Lei, Wei Li, Gang Wu, Jun Lyu, Zhi-Ming Dai, Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection,International Journal of Infectious Diseases, 2020, 96:19-24. IF: 3.202.
7． Meng-Lu Xu, Xiao-Jing Yu, Jian-Qiang Zhao, Yan Du, Wen-Jie Xia, Qing Su, Meng-Meng Du, Qing Yang, Jie Qi, Ying Li, Shao-Wen Zhou, Guo-Qing Zhu,Hong-Bao Li*(通讯作者), Yu-Ming Kang. Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR.Toxicology and Applied Pharmacology, 2020, 394:114950. IF: 3.585.
8． Tao Yang,Hong-Bao Li,Aline C Oliveira, Ruby Goel，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats，Physiological Genomics，2020, 2(3):121-132. IF: 2.749.
9． Tao Yang, Victor Aquino, Gilberto O. Lobaton,Hong-Bao Li,Luis Colon-Perez, Ruby Goel, Yan-Fei Qi, Jasenka Zubcevic, Marcelo Febo, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Sustained captopril-Induced reduction in blood pressure is associated with alterations in gut-brain axis in the spontaneously hypertensive rat,Journal of the American Heart Association, 2019, 8(4):e010721. IF: 4.605.
10．Xiao-Jing Yu, Yu-Wang Miao,Hong-Bao Li (共同一作), Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang, Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension,Neuroscience Bulletin, 2019, 35(1):47-56. IF: 4.326.
11．Hong-Bao Li, Chan-Juan Huo, Qing Su, Xiang Li, Juan Bai, Guo-Qing Zhu, Yu-Ming Kang, Exercise training attenuates proinflammatory cytokines, oxidative stress and modulates neurotransmitters in the rostral ventrolateral medulla of salt-induced hypertensive rats,Cellular Physiology and Biochemistry, 2018;48(3):1369-1381. IF: 5.5.
12．Hong-Bao Li, Xiang Li, Chan-Juan Huo, Qing Su, Jing Guo, Zu-Yi Yuan, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang, TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension,Toxicology and Applied Pharmacology, 2016, 305:93-102. IF: 3.791.
13．Qiu-Yue Yi,Hong-Bao Li (共同一作),Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang,Toxicology letters, 2016, 262:105-113. IF: 3.858.
14．Hong-Bao Li, Da-Nian Qin, Kang Cheng, Qing Su, Yu-Wang Miao, Jing Guo, Meng Zhang, Guo-Qing Zhu, Yu-Ming Kang, Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats,Scientific Reports, 2015, 5:11162. IF: 5.228.
15．Hong-Bao Li, Da-Nian Qin, Yu-Ping Suo, Jing Guo, Qing Su, Yu-Wang Miao, Wen-Yan Sun, Qiu-Yue Yi, Wei Cui, Kang Cheng, Guo-Qing Zhu, Yu-Ming Kang, Blockade of salusin β in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy in salt-induced hypertensive rats,Journal of cardiovascular pharmacology, 2015, 66(4):323-331. IF: 2.538.
16．Hong-Bao Li, Yan Lu, Jin-Jun Liu, Yu-Wang Miao, Tian-Zhen Zheng, Qing Su, Jie Qi, Hong Tan, Zu-Yi Yuan, Guo-Qing Zhu, Yu-Ming Kang, Salusin β within the nucleus tractus solitarii suppresses blood pressure via inhibiting the activities of presympathetic neurons in the rostral ventrolateral medulla in spontaneously hypertensive rats,Cardiovascular Toxicology, 2016, 16(3):223-234.IF: 2.712.
17．Hong-Bao Li, Da-Nian Qin, Le Ma, Yu-Wang Miao, Dong-Mei Zhang, Yan Lu, Xin-Ai Song, Guo-Qing Zhu, Yu-Ming Kang, Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension,Toxicology and Applied Pharmacology, 2014, 279(2):141-149. IF: 3.973.

联系方式：
电子邮箱：hongbaoli1985@163.comorlhb**@mail.xjtu.edu.cn
联系电话：**
个人主页： http://gr.xjtu.edu.cn/web/lhb**
联系地址：西安市雁塔西路76号西安交通大学医学部