基本信息
姓名 夏玉琼
职位 副教授 硕士生导师
博士学科：高分子化学与物理
硕士学科：高分子化学与物理　
工作单位：西安电子科技大学生命科学与技术学院生物技术系

联系方式
通信地址：
陕西省西安市长安区西安电子科技大学南校区 710126
电子邮箱：
yqxia@xidian.edu.cn


个人简介
主要从事针对肿瘤成像的高性能脂质体纳米荧光探针的构建和脂质体纳米诊疗一体化系统的研究。主持和参与了多项国家自然科学青年基金和陕西省自然科学基金等研究项目，并参与了国家自然科学基金重点项目和国家重点基础研究发展科研项目。研究成果在国际期刊Chemical Society Reviews、Advanced Materials、Biomaterials、Nanoscale等SCI核心刊物共计发表论文19篇，其中第一作者SCI论文10篇。2014.08-2015.08，获国家留学基金委国家公派出国留学资格，以公派访问****身份在美国国立卫生研究院访问交流1年。

主要研究方向
1. 基于脂质体的肿瘤成像探针的开发。
2. 针对肿瘤治疗的脂质体纳米药物的开发。


常用链接
西电西电生科院人事处 科研处图书馆财务处课表查询
分子影像与转化医学团队Web of Science Pubmed图书馆数据库
小木虫论坛维基百科

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基本信息
姓名 夏玉琼
职位 副教授 硕士生导师
博士学科：高分子化学与物理
硕士学科：高分子化学与物理　
工作单位：西安电子科技大学生命科学与技术学院生物技术系

联系方式
通信地址：
陕西省西安市长安区西安电子科技大学南校区 710126
电子邮箱：
yqxia@xidian.edu.cn


个人简介
主要从事针对肿瘤成像的高性能脂质体纳米荧光探针的构建和脂质体纳米诊疗一体化系统的研究。主持和参与了多项国家自然科学青年基金和陕西省自然科学基金等研究项目，并参与了国家自然科学基金重点项目和国家重点基础研究发展科研项目。研究成果在国际期刊Chemical Society Reviews、Advanced Materials、Biomaterials、Nanoscale等SCI核心刊物共计发表论文19篇，其中第一作者SCI论文10篇。2014.08-2015.08，获国家留学基金委国家公派出国留学资格，以公派访问****身份在美国国立卫生研究院访问交流1年。

主要研究方向
1. 基于脂质体的肿瘤成像探针的开发。
2. 针对肿瘤治疗的脂质体纳米药物的开发。


常用链接
西电西电生科院人事处 科研处图书馆财务处课表查询
分子影像与转化医学团队Web of Science Pubmed图书馆数据库
小木虫论坛维基百科

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科学研究
在研课题：
1. 基于脂质体的荧光肿瘤探针的构建
2. 基于脂质体的肿瘤纳米药物的构建
在研项目：
1. 高校基本科研业务费，蛋白质药物的高效细胞质递送策略研究，JB211201, 2021.1-2022.12
已结题项目：
1. 国家自然科学基金青年基金，基于脂质体/金纳米棒复合材料的光控药物释放体系及其胃癌治疗研究，2016.1-2018.12
2. 陕西省自然科学基础研究计划一般项目（青年），酶辅助下的金/聚多巴胺纳米粒子探针对miRNA的高灵敏度检测，2019.1-2020.12
3. 高校基本科研业务费，克服多耐药性的饥饿治疗/化疗联合治疗研究，2019.1-2020.12

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学术论文
16.Zhang, X.; Zhao, S.; Gao, Z.; Zhou, J.; Xia, Y.; Tian, J.; Shi, C.; Wang, Z., Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced antitumor phototherapy in vivo. Nano Research 2021, 1-9. (SCI一区)
15. Xianghan Zhang, Xiaohan Gao, Jialin Zhou, Yingdi Tang, Zuhong Tian, Pengbo Ning and Yuqiong Xia*，Albumin-based fluorescence resonance energy transfer nanoprobes for multileveled tumor tissue imaging and dye release imaging，Colloids and Surfaces B: Biointerfaces，2020, 199. （SCI二区，IF = 3.952）
14. Yuqiong Xia, Lang Rao, Huimin Yao, Zhongliang Wang*, Pengbo Ning*, Xiaoyuan Chen*, Engineering Macrophages for Cancer Immunotherapy and Drug Delivery, Adv Mater, (2020) e**. （SCI一区，IF = 22.517，Review）
13. Yuqiong Xia, Pengbo Ning, Zhongliang Wang*, Xiaoyuan Chen*, Calming the Cytokine Storm in Pneumonia by Biomimetic Nanoparticles, Matter, 2020, 3, 18-20. (Preview)
12.Yuqiong Xia*, Chunzhong Xu, Xianghan Zhang, Jingkai Gao, Yankun Wu, Cairu Li, Zhongliang Wang*, Colloids Surf B Biointerfaces, 2020, 188, 110789. DOI:10.1016/j.colsurfb.2020.110789.(IF=4.11)
11.Yuqiong Xia, Chunzhong Xu, Xianghan Zhang, Pengbo Ning, Zhongliang Wang*, Jie Tian*, Xiaoyuan Chen*, Nanoscale, 2019, 11 (13), 5822-5838. DOI: 10.1039/c9nr00207c. (IF=7.17) (Review)
10. Yuqiong Xia*, Mei Fang, Jingyu Dong, Chunzhong Xu, Zhen Liao, Pengbo Ning, Qi Zeng, pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells.Colloids and Surfaces B: Biointerfaces 2018,170, 514-520. (IF=3.997)
9. Zhang, X.; Wang, B.; Xia, Y.; Zhao, S.; Tian, Z.; Ning, P.; Wang, Z., In Vivo and in Situ Activated Aggregation-Induced Emission Probes for Sensitive Tumor Imaging Using Tetraphenylethene-Functionalized Trimethincyanines-Encapsulated Liposomes. ACS Appl. Mater. Interfaces 2018, 10 (30), 25146-25153. (SCI一区)
8. Yuqiong Xia*, Xiaofei Wang, He Cheng, Mei Fang, Pengbo Ning, Yulu Zhou, Wei Chen, Hongjin Song, A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance. Colloids and Surfaces B: Biointerfaces 2017, 159, 427-436.(IF=3.997)
7. Yuqiong Xia, Ruili Zhang, Zhongliang Wang*, Jie Tian*, Xiaoyuan Chen*,Recent Advances in High-Performance fluorescent and bioluminescent RNA Imaging Probes, Chem Soc Rev, 2017;46 (10), 2824-2843. DOI:10.1039/C6CS00675B. (Review)
6.Yuqiong Xia,Jie Tian*, Xiaoyuan Chen*, Effect of surface properties on liposomal siRNA delivery. Biomaterials. 2016;79:56-68. (Review)
5.Yuqiong Xia*,Shuo Qi, Xinlong Zhang, Lei Li, Xiaochao Qu*, Xianghan Zhang, Jimin Liang, Construction of thermal- and light-responsive liposomes noncovalently decorated with gold nanoparticles, RSC Advances, 2014, 4, 44568.
4.Yuqiong Xia,Jianbo Sun, Dehai Liang*, Aggregation, Fusion, and Leakage of Liposomes Induced by peptides.Langmuir, 2014, 30(25), 7334-7342
3. Jianbo Sun,Yuqiong Xia(co-first author), Dong Li, Quan Du*, Dehai Liang*, Relationship between peptide structure and antimicromobial activity as studied by de novo designed peptides,Biochimica et Biophysica Acta, 2014, 1838, 2985-2993.
2.Yuqiong Xia,Min Gao, Ye Chen, Xinru Jia*, Dehai Liang*, Synthetic protein mimic: a highly pH-sensitive and Thermo-responsive Polyampholyte.Macromolecular Chemistry and Physics, 2011,212(20), 2268-2274.
1.Yuqiong Xia,Erqiang Chen, Dehai Liang*, Recognition of Single- and Double-Stranded Oligonucleotides by Bovine Serum Albumin via Nonspecific Interactions. Biomacromolecules, 2010, 11, 3158-3166.


专利
[1] 夏玉琼，许春仲，张象涵，王忠良，张瑞丽，吴延坤，李采儒，一种开关型脂质体纳米荧光探针及其制备方法和用途，申请号2.6，发文序号：39770，发文日：2021年5月19日。

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科研团队
硕士研究生

毕业生去向
2017级硕士生许XX 深圳普门科技股份有限公司

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本科生课程
课程
生物技术制药（双语）Biotechnological PharmaceuticsLS025005
教改项目
1. 西安电子科技大学教育教学改革研究项目，面向国际化的生物药物课程的教学模式的探索与研究，2021.1-2022.12
2. 西安电子科技大学新实验开发项目，聚乙烯亚胺/DNA复合物的zeta电势和粒径分析，2015.1-2016.12
教改论文
1. 夏玉琼，谢晖，曾琦，程贺，梁德海，《基于合成非病毒基因载体的教学实验开发》，实验室科学，2017，20（2），47-50。

研究生课程
生物药物的开发与应用X2LS2023

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硕士研究生招生
招生学科：077700 生物医学工程
学科方向：00 不区分研究方向
招生学科：083100 生物医学工程
学科方向：02 生物材料与细胞工程
招生专业领域：085230 生物医学工程（专业学位）
专业领域方向：00 不区分研究方向
研究方向：基于纳米载体的肿瘤早期诊断、肿瘤联合治疗
欢迎同学们报考我们课题组的研究生！
欢迎有志于科研的本科生加入课题组！

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Profile
Yuqiong Xia
Associate Professor
School of Life Science and Technology, Xidian University

Contact Information
Address:
266 Xinglong Section of Xifeng Road, Xi'an, Shaanxi 710126
China
Email: yqxia@xidian.edu.cn


Experience and Education
Experience
Sep 2017 - present Associate ProfessorSchool of Life Science and Technology, Xidian University
Sep 2015 - Aug 2017 Assistant Professor in School of Life Science and Technology, Xidian University
Aug 2014 - Aug 2015 Visiting Scholar in National Institutes of Health
Jul 2012 - Aug 2014 Assistant Professor in School of Life Science and Technology, Xidian University
Education
Sep 2007 - Jul 2012 Polymer Chemistry and Physics, Peking University, PhD degree
Sep 2003 - Jul 2007 Chemistry, Nanjing University, Bachelor's degree


Research Interests
1. Liposome-based tumor imaging probes
2. miRNA imaging probes

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Research
Funding:
National Natural Science Foundation of China 2016.1-2018.12
Projects:
1. Liposome-based tumor imaging probes
2. miRNA imaging probes

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Papers
11.Yuqiong Xia*, Chunzhong Xu, Xianghan Zhang, Jingkai Gao, Yankun Wu, Cairu Li, Zhongliang Wang*, Colloids Surf B Biointerfaces, 2020, 188, 110789. DOI:10.1016/j.colsurfb.2020.110789.(IF=4.11)
10.Yuqiong Xia, Chunzhong Xu, Xianghan Zhang, Pengbo Ning, Zhongliang Wang*, Jie Tian*, Xiaoyuan Chen*, Nanoscale, 2019, 11(13), 5822-5838. DOI: 10.1039/c9nr00207c. (IF=7.17)
9. Yuqiong Xia*, Mei Fang, Jingyu Dong, Chunzhong Xu, Zhen Liao, Pengbo Ning, Qi Zeng, pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells.Colloids and Surfaces B: Biointerfaces 2018,doi:10.1016/j.colsurfb.2018.06.055
8. Yuqiong Xia*, Xiaofei Wang, He Cheng, Mei Fang, Pengbo Ning, Yulu Zhou, Wei Chen, Hongjin Song, A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance. Colloids and Surfaces B: Biointerfaces 2017, 159, 427-436.

7. Yuqiong Xia, Ruili Zhang, Zhongliang Wang*, Jie Tian*, Xiaoyuan Chen*,Recent Advances in High-Performance fluorescent and bioluminescent RNA Imaging Probes, Chem Soc Rev, 2017;46 (10), 2824-2843. DOI:10.1039/C6CS00675B.
6.Yuqiong Xia,Jie Tian*, Xiaoyuan Chen*, Effect of surface properties on liposomal siRNA delivery.Biomaterials.2016;79:56-68.
5.Yuqiong Xia*,Shuo Qi, Xinlong Zhang, Lei Li, Xiaochao Qu*, Xianghan Zhang, Jimin Liang, Construction of thermal- and light-responsive liposomes noncovalently decorated with gold nanoparticles,RSC Advances,2014, 4, 44568.
4.Yuqiong Xia,Jianbo Sun, Dehai Liang*, Aggregation, Fusion, and Leakage of Liposomes Induced by peptides.Langmuir,2014, 30(25), 7334-7342
3. Jianbo Sun,Yuqiong Xia(co-first author), Dong Li, Quan Du*, Dehai Liang*, Relationship between peptide structure and antimicromobial activity as studied by de novo designed peptides,Biochimica et Biophysica Acta,2014, 1838, 2985-2993.
2.Yuqiong Xia,Min Gao, Ye Chen, Xinru Jia*, Dehai Liang*, Synthetic protein mimic: a highly pH-sensitive and Thermo-responsive Polyampholyte.Macromolecular Chemistry and Physics,2011,212(20), 2268-2274.
1.Yuqiong Xia,Erqiang Chen, Dehai Liang*, Recognition of Single- and Double-Stranded Oligonucleotides by Bovine Serum Albumin via Nonspecific Interactions.Biomacromolecules,2010,11, 3158-3166.

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Team
Graduate
Zhongchun Xu
Cairu Li, Yankun Wu
Undergraduate
Senior: Jingyu Dong, Zhen Liao
Graduated: Mengjie Lai, Zhen Zhen, Xiaosong Bu, Hao Hao, Shuo Qi, Xinlong Zhang,Pengpeng Li, Yetao Wang,Xiaofei Wang, He Cheng, Jinkun Fan, Xuan Wang

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Teaching
Courses:
Pharmaceutical Biotechnology

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Admission
Still unavailable.