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西北农林科技大学动物科技学院导师教师师资介绍简介-李晓

本站小编 Free考研考试/2021-07-07


1.基本信息
李晓,河北省辛集人,博士,副教授,博士生导师。2001-2005年本科就读于南京农业大学动物医学院,2005-2011年硕博连读,毕业于南京农业大学农业部动物生理生化重点开放实验室。2009年1月至2011年1月先后在美国弗吉尼亚理工大学、美国康奈尔大学进行合作科研,2017年11月至2018年11月在美国华盛顿州立大学进行交流访问。2012年1月至今,任教于西北农林科技大学动物科技学院。
中国畜牧兽医学会动物生理学分会会员、动物遗传育种学分会会员,在Frontiers开设Marbling fat in livestock专题,为Frontiers in Cell and Developmental Biology/ Molecular Biosciences/ Genetics/ Veterinary Sciences等杂志组稿。
2.研究方向
优良猪肉品质形成的生理学和遗传学基础;新型猪生长调节剂的研发和推广;细胞培养肉流程的设计和优化;特色品种遗传多样性调查。
3.开设课程
开展动物细胞生物学的教学与科研工作,参与细胞生物学精品课程和双语课程的建设。
4.学术成果
主持项目:
1. 发酵桑叶改良猪胴体品质的应用研究(2019NY-078),陕西省重点研发计划—一般项目,2019-2020,10万元
2. MyHC-AS调控猪骨胳肌II型MyHCs转录的机制研究(**),国家自然科学基金青年科学基金项目,2016-2018,19万元(直接经费)
3. PPARγ-AMPK差异性调控猪脂肪沉积的作用机制(),中央高校基本科研业务费——科技创新一般项目,2019-2020,7万元
4. IGF2-AS调控猪肌肉IGF2启动子活性的分子机制(2014JQ3103),陕西省自然科学基金青年项目,2014-2015,3万元
5. Wnt/β-catenin调节MSTN启动子活性的分子机制(2014M562465),中国博士后科学基金第56批面上资助(二等),2014-2016,5万元
6. 伪受体BAMBI在myostatin抑制猪骨骼肌卫星细胞增殖过程中的作用(2014YB005),中央高校基本科研业务费——科技创新一般项目,2014-2016,10万元
7. 猪miR-17-92簇启动子克隆及其活性分析(2012BSJJ095),西北农林科技大学博士科研启动基金暨陕西省专项配套经费,2013-2015,10万元
参加项目
1. 重要候选功能基因在成肌-成脂及其平衡中的作用分析(2018YFD**-3),国家重点研发计划,2018-2020,55.17万
2. 抗病高产转基因猪新品种培育(2016ZX08006-003),国家转基因生物新品种培育重大专项,2016-2020,354.99万
3. 猪脂肪沉积关键基因BAMBI的克隆及功能验证(2014ZX**B),国家转基因生物新品种培育重大专项,2014-2016,170.9万元
4. circSNX25调控猪骨骼肌纤维类型转化的分子机制(**),国家自然科学基金面上项目,2018-2021,60万元(直接经费)
5. 胶原XV通过“Ca2+-内质网”轴调节猪白色脂肪棕色化的作用机制(**),国家自然科学基金面上项目,2016-2019,64万元(直接经费)
6. CLOCK:BMAL1介导的钟基因对绒山羊次级毛囊周期性再生的表观遗传学调控(**),国家自然科学基金青年科学基金项目,2016-2018,19万元(直接经费)
7. 近红外荧光增强型靶向纳米探针构建及细胞-药物作用可视化(**),国家自然科学基金青年科学基金项目,2015-2017,25万元
8. APS调控种公鸡Th细胞因子表达的父系传代表观遗传机制(**),国家自然科学基金面上项目,2013-2016,60万元
主要论著
1.期刊论文(仅列第一作者或通讯作者,更多请访问https://www.researchgate.net/profile/Xiao_Li219)
[1] Mingle Dou, Ying Yao, Ying Peng, Meixue Xu, Xin’e Shi, Gongshe Yang, Xiao Li*. The long noncoding RNA MyHC IIA/X-AS contributes to skeletal muscle myogenesis and maintains the fast fiber phenotype. Journal of Biological Chemistry, 2020 Apr 10; 295(15):4937-4949, DOI: 10.1074/jbc.RA119.010498
[2] Xiaoyu Wang1, Huifang Zhang1, Xin’E Shi, Gongshe Yang, Shiduo Sun, Xiao Li*. Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and FASN, respectively. Acta Biochimica et Biophysica Sinica (Shanghai), 2020 May 22 accepted, DOI:10.1093/abbs/gmaa111
[3] Xiaoyu Wang, Meixue Xu, Ying Peng, Qimuge Naren, Yanting Xu, Xin Wang, Gongshe Yang, Xin’E Shi, Xiao Li*. Triptolide enhances lipolysis of adipocytes by enhancing ATGL transcription via upregulation of p53. Phytotherapy Research, 2020 July 02 online, DOI: 10.1002/ptr.6779
[4] Xiaoyu Wang1, Jing Yang1, Ying Yao, Xin’E Shi, Gongshe Yang, Xiao Li*. AQP3 facilitates proliferation and adipogenic differentiation of porcine intramuscular adipocytes. Genes, 2020 Apr 22;11(4). pii: E453. doi: 10.3390/genes**
[5] Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’E Shi, Gongshe Yang, Xiao Li*. Morus nigra L. leaves improve the meat quality in finishing pigs. Journal of animal physiology and animal nutrition, 2020 Aug 28 online, DOI: 10.1111/jpn.13439
[6] Yixin Chu, Ying Yao, Youbo Zhu, Xin’e Shi, Shiduo Sun, Xiao Li*. MiR-370 enhances cell cycle and represses lipid accumulation in porcine adipocytes. Animal Biotechnology, 2019, Dec 03; 1-9, doi: 10.1080/**.2019.**
[7] Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’e Shi, Gongshe Yang, Xiao Li*. Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model. Journal of Ethnopharmacology, 2020 Mar 1; 249: 112416. doi.org/10.1016/j.jep.2019.112416
[8] Xiao Li, Xing Fu, Gongshe Yang, Min Du*. Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals. Animal, 2020 Feb;14(2):312-321. doi: 10.1017/S**0209X
[9] 武丹,李晓*.冷鲜肉保鲜过程中的微生物污染及其预防措施.食品工业科技. 2019, 40 (21):320-325
[10] Lujie Fan, Mingle Dou, Xiaoyu Wang, Qichun Han, Bo Zhao, Jianhong Hu, Gongshe Yang, Xin’E Shi, Xiao Li*. Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs. Journal of Animal Science, 2018, Sep 8th, 96(12): 5144-5151. doi: 10.1093/jas/sky361
[11] Xiao Li1, Youbo Zhu1, Huifang Zhang, Guangjun Ma, Guofang Wu, Aoqi Xiang, Xin'E Shi, GongShe Yang, Shiduo Sun*. MicroRNA-106a-5p inhibited C2C12 myogenesis via targeting PIK3R1 and modulating the PI3K/AKT signaling. Genes (Basel), 2018, July, 2, 9(7): E333
[12] 樊路杰, 窦鸣乐, 王小宇, 李泽, 史新娥, 李晓*. 宰后肌肉抗氧化能力与肌肉品质的关系. 动物营养学报, 2018, May, 15, 30(5):1676-1680.
[13] YouLei Li#, Xiao Li#, TianTuan Jiang, JiaMeng Fan, XueLi Zheng, XinE Shi, TaiY ongYu, GuiYan Chu, GongShe Yang. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of Rosiglitazone and CL316,243. International Journal of Molecular Science, 2017, 18(5): pii: E1002
[14] Xiao Li#, Jing Yang#, Youbo Zhu, Yuan Liu, Xin’e Shi, Gongshe Yang. Maternal high-fat intake dynamically programmed mRNA m6A modifications in adipose and skeletal muscle tissues in offspring. International Journal of Molecular Science, 2016, 17(8): pii: E1336
[15] Xiao Li#, Kuilong Huang#, Fenfen Chen, Wanhua Li, Shiduo Sun, Xin-E Shi, Gongshe Yang. Verification of suitable and reliable reference genes for quantitative real-time PCR during adipogenic differentiation in porcine intramuscular stromal-vascular cells. Animal, 2016, 10(6): 947-952
[16] Qiangling Zhang, Xin-E Shi, Chengchuang Song, Shiduo Sun, Gongshe Yang, Xiao Li*. BAMBI promotes C2C12 myogenic differentiation by enhancing Wnt/β-catenin signaling. International Journal of Molecular Science, 2015, 16(8), 17734-17745
[17] Xiao Li#, Jinquan Wang#, Zheng Jiang, Feng Guo, Paul D Soloway, Ruqian Zhao. Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells. Gene. 2015, 570(2), 191-198
[18] Chengchuang Song, Guofang Wu, Aoqi Xiang, Qiangling Zhang, Wanhua Li, Gongshe Yang, Shiduo Sun*, Xiao Li*. Over-expression of miR-125a-5p inhibits proliferation in C2C12 myoblasts by targeting E2F3. Acta Biochimica et Biophysica Sinica(Shanghai), 2015, 47(4), 244-249
[19] Xiao Li#, Li Qiu, Zengqi Yang, Ruyi Dang, Xinglong Wang. Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure. BMC Veterinary Research, 2013, 9:26
[20] Jinquan Wang#, Xiao Li#, Xiaojing Yang, Qinwei Sun, Ruihua Huang, Jun Xing, Ruqian Zhao. Maternal dietary protein induces opposite myofiber type transition in Meishan pigs at weaning and finishing stages. Meat Science. 2011, 89: 221-227
[21] Xiao Li, Xiaojing Yang, Bin Shan, Jian Shi, Dong Xia, J Wegner, Ruqian Zhao. Meat quality is associated with muscle metabolic status but not contractile myofiber type composition in premature pigs. Meat Science. 2009, 81: 218-223
5.联系方式
通讯地址:陕西杨凌西农路22号 西北农林科技大学动物科技学院
邮编:712100
联系电话:
Email: nice.lixiao@gmail.com;nicelixiao@nwsuaf.edu.cn







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