张小里
所属部门： 食品科学与工程学院
职务/职称： 教授
荣誉： 博士生导师
电子邮件： xlzhang@nwu.edu.cn
个人简介 工学博士，教授，博士生导师。1962年3月出生。西北大学有机化工、化学工程专业本科、硕士毕业，获工学学士、硕士学位；浙江大学生物化工专业毕业，获工学博士学位，博士学位论文《酵母系统超量生产代谢中间物和外源基因产物的应用基础研究》。先后两次公派赴日本名古屋大学生物机能工学科留学或访问研究。
自1983年任教以来，曾主讲《化学反应工程》、《生物反应工程》、《酶工程》、《工业催化》、《生物催化过程》、《生物催化理论与技术》等本科及研究生课程。
从事发酵与酶工程、催化反应工程、新资源食品及添加剂催化合成等领域研究，主持国家自然科学基金、国家留学基金、陕西省自然科学基金、陕西省教育厅基金等政府和企业委托科研项目，发表研究论文120余篇，其中30余篇被SCI、EI权威索引收录；申请发明专利6件。

研究成果 外文刊物研究论文（部分）
[1] Bin Li, Dan Chen, Xiaoli Zhang, Wenbo Dong, Binxia Zhao, A convenient method to immobilize 4-dimethylaminopyridine on silica gel as a heterogeneous nucleophilic catalyst for acylation, Chemical Papers, https://doi.org/10.1007/s11696-018-0381-2, Published Online: 13 January 2018.
[2] Bin Li, Hongya Li, Xiaoli Zhang, Pengjuan Fan, Lei Liu, Binglin Li, Wenbo Dong, Binxia Zhao, Calcined sodium silicate as an efficient and benign heterogeneous catalyst for the transesterification of natural lecithin to L-α-glycerophosphocholine, Green Process Synth., https://doi.org/10.1515/gps-2017-0190, Published Online: 2018-02-21.
[3] Xiaoli Zhang, Binglin Li, Jiao Wang, Huanyu Li, and Binxia Zhao, High-Yield and Sustainable Production of Phosphatidylserine in Purely Aqueous Solutions via Adsorption of Phosphatidylcholine on Triton-X-100-Modified Silica, J. Agric. Food Chem., 2017, 65, 10767-10774.
[4] Binglin Li, Jiao Wang, Xiaoli Zhang, Bin-xia Zhao, Lu Niu,Aqueous–Solid System for Highly Efficient and Environmentally Friendly Transphosphatidylation Catalyzed by Phospholipase D to Produce Phosphatidylserine J. Agric. Food Chem. 2016, 64, 7555– 7560.
[5] Li, Binglin; Wang, Jiao; Zhang, Xiaoli; Zhao, Bin-xia, Li, Binglin; Wang, Jiao; Zhang, Xiaoli; Zhao, Bin-xia,An Enzyme Net Coating the Surface of Nanoparticles: A Simple and Efficient Method for the Immobilization of Phospholipase D, Ind. Eng. Chem. Res., 2016, 55 (40), 10555–10565.
[6] Hongya Li, Xiaoli Zhang, Biao Yan, Binxia Zhao, Jing Gao, Preparation and catalytic performance of quaternary ammonium base resin for methanolysis of natural phosphatidylcholine, Chemical Papers, 2016 , 70 (6),706–712.
[7] Ye, Wei; Zhao, Binxia; Gao, Han; Huang, Jiajun; Zhang, Xiaoli, Preparation of highly efficient and stable Fe,Zn,Al-pillared montmorillonite as heterogeneous catalyst for catalytic wet peroxide oxidation of Orange II, Journal of Porous Materials, 2016, 23(2), 301-310.
[8] Yaozhong Zhang; Jun Zhou; Xiaoli Zhang; Jun Hu, Kinetics behavior of long-chain n-alkanethiols adsorbed on copper surface, Applied Surface Science, 2015,353, 979-985.
[9] Yaozhong Zhang; Jun Zhou; Xiaoli Zhang; Jun Hu; Han Gao, Solvent polarity effect on quality of n-octadecanethiol self-assembled monolayers on copper and oxidized copper, Applied Surface Science, 2014, 320, 200-206.
[10] Gao, Han; Zhao, Bin-Xia; Luo, Jin-Chao; Wu, Di; Ye, Wei; Wang, Qi; Zhang, Xiao-Li, Fe-Ni-Al pillared montmorillonite as a heterogeneous catalyst for the Catalytic Wet Peroxide Oxidation degradation of Orange Acid II: Preparation condition and properties study, Microporous and Mesoporous Materials, 2014, 196, 208-215.
[11] Li, Hong-Ya; Zhang, Xiao-Li; Zhang, Jie-Bing; Zhang, Tian-Tian; Zhao, Bin-Xia, Preparing L-alpha-Glycerophosphocholine in a Phase-Transfer Catalytic Reaction: Kinetic Study, International Journal of Chemical Kinetics, 2014, 46(3), 169-175.
[12] Zhang, Tiantian; Zhang, Xiaoli; Li, Hongya; Bai, Weili; Zhao, Binxia, Kinetic evaluation of the ethanolysis of phosphatidylcholine catalyzed by choline hydroxide, Reaction Kinetics, Mechanisms and Catalysis, 2013, 110(1), 31-39.
[13] Gao Hu-Fei; Zhao Bin-Xia; Liu Wei-Juan; Liu Lin-Xue; Ye Wei; Gao Han; Zhang Yi; Zhang Xiao-Li, Preparation of ZnO/Co-MCM-41 Molecular Sieves and Their Catalytic Performance for Isoamyl Alcohol Oxidation, Chemical Journal of Chinese Universities, 2013, 34(7), 1723-1730.
[14] Li, Hongya; Zhang, Xiaoli; Bai, Weili; Zhang, Jiebing; Zhang, Tiantian; Zhao, Binxia, Study on the preparation of L-alpha-glycerophosphocholine catalyzed by low boiling point organic amines, Reaction Kinetics, Mechanisms and Catalysis, 2013, 108(2), 305-316.
[15] Li, Hongya; Zhang, Xiaoli; Zhang, Tiantian; Dou, Kunkun; Zhao, Binxia, Study on the methanolysis of natural lecithin catalyzed by quaternary ammonium base resin, Reaction Kinetics, Mechanisms and Catalysis, 2012, 7(2), 345-354.
[16]Zhang Yi; Zhao Bin-Xia; Zhang Xiao-Li; Gao Hu-Fei; Zhang Yao-Zhong, Catalytic Oxidation of Isoamyl Alcohol to Isoamyl Isovalerate Directly on Fe2O3-ZnO/SiO2, Chinese Journal of Inorganic Chemistry, 2012, 28(11), 2347-2354.
[17] Zhang, Jiebing; Zhang, Xiaoli; Li, Hongya; Zhao, Binxia, Ion Exchange Adsorption Studies of Miglitol in a Fixed Bed, Chemical Engineering & Technology, 2012, 35(5), 811-818.
[18] Zhao, Binxia; Shi, Binchu; Zhang, Xiaoli; Cao, Xin; Zhang, Yaozhong, Catalytic wet hydrogen peroxide oxidation of H-acid in aqueous solution with TiO2-CeO2and Fe/TiO2-CeO2catalysts, Desalination, 2011, 268(1-3), 55-59.
[19] Z. Jia; X. Zhang; B. Qin; J. Liu; X. Cao, Production of lovastatin by a self-resistant mutant of Aspergillus terreus, Annals of Microbiology, 2011, 61(3), 615-621.
[20] Z. H. Jia; X. L. Zhang; Y. L. Zhao; X. J. Cao, Enhancement of Lovastatin Production by Supplementing Polyketide Antibiotics to the Submerged Culture of Aspergillus terreus, Applied Biochemistry and Biotechnology, 2010, 160(7), 2014-2025.
[21] Zhao Bin-Xia; Zhang Xiao-Li; Li Hong-Ya; Liu Lin-Xue; Jin Qi-Ting, Catalytic Activities of MnOx-CeO2 Catalysts in Wet Air Oxidation of Pesticide Wastewater, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2009, 30(5), 965-970.
[22] Z. H. Jia, X. L. Zhang; X. J. Cao, Effects of carbon sources on fungal morphology and lovastatin biosynthesis by submerged cultivation of Aspergillus terreus, Asia-Pacific Journal of Chemical Engineering, 2009,4(5), 672-677.
[23] Z. H. Jia, X. L. Zhang, Y. L. Zhao; X. J. Cao, Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreusin chemically defined medium, World Journal of Microbiology and Biotechnology, 2009, 25(7), 1235-1241.
[24] X. L. Zhang, T. Ito, K. Kondo, T. Kobayashi; H. Honda, Production of single chain recombinant monellin by high cell density culture of genetically engineered Candida utilisusing limited feeding of sodium ions, Journal of Chemical Engineering of Japan, 2002, 35(7), 654-659.
[25] X. L. Zhang, Z. J. Xia, B. X. Zhao; P. L. Cen, Enhancement of plasmid stability and protein productivity using multi-pulse, fed-batch culture of recombinant Saccharomyces cerevisiae, Biotechnology Letters, 2002, 24(12), 995-998.
[26] X. L. Zhang, Z. J. Xia, B. X. Zhao; P. L. Cen, Enhancement of production of cloned alpha-amylase by lactic acid feeding from recombinant Saccharomyces cerevisiaeusing a SUC2 promoter, Biotechnology Letters, 2001, 23(4), 259-262.
[27] T. Ohshima, Y. Kawase, X. L. Zhang, S. Iijima, T.; Y. H. Murooka, On-Off Control of Gene-Expression from Lambda-Phage pRpLPromoter in High-Concentration Cultivation of Gene-Engineered Escherichiacoli, Kagaku Kogaku Ronbunshu (in Japanese), 1992, 18(5), 684-692.
[28] T. Ohshima, X. L. Zhang, S. Iijima, T. Kobayashi; F. Hishinuma, Control of Gene-Expression from the SUC2 Promoter of SaccharomycescerevisiaeUsing 2 Carbon-Sources, Kagaku Kogaku Ronbunshu (in Japanese), 1992,18(5), 693-700.
中文刊物研究论文（部分）
[1]邓杨敏; 李冰麟; 董文博; 杨开利; 张小里; 赵彬侠, 磷脂酰乙醇胺的酶促合成及底物抑制动力学. 化工进展2017, (07), 2601-2606.
[2]杨兰兰; 张小里; 封娟娟; 朱南南; 赵彬侠, 磷脂酶D高产菌株的原生质体紫外诱变选育. 生物加工过程2016, (02), 22-26.
[3]任方旭; 孙全莲; 董文博; 张小里; 赵彬侠, 发酵液中鼠李糖脂的活性炭吸附-酸沉淀分离. 化学工程2016, (07), 15-18.
[4]封娟娟; 朱南南; 邓杨敏; 韩晓玲; 张小里; 赵彬侠, 反复分批式反应提高磷脂酰丝氨酸的生产能力. 化工进展2016, (04), 1180-1183.
[5]陈庆; 张小里; 王建雄, 氨基膦酸螯合树脂吸附癸二酸中铁离子的研究. 化学工程2016, (03), 26-29+45.
[6]孙甜; 赵彬侠; 王琪; 孙烨; 王蒙; 高敏; 张小里, 铁锆柱撑蒙脱土的制备及其催化湿式过氧化氢氧化染料废水的研究. 高校化学工程学报2014, (03), 659-664.
[7]王端好; 张小里, 山梨醇脱氢酶性质研究. 生物技术2013, (01), 70-73.
[8]高虎飞; 赵彬侠; 刘卫娟; 刘林学; 叶维; 高晗; 章毅; 张小里, Co掺杂ZnO/MCM-41分子筛的制备及对异戊醇的催化氧化性能. 高等学校化学学报 2013, (07), 1723-1730.
[9] 章结兵; 张小里; 李红亚; 赵彬侠, 固定床动力学模型在离子交换过程中的应用. 化学工程2012, (05), 54-56+69.
[10]章结兵; 张小里; 李红亚; 赵彬侠, 固定床中米格列醇的离子交换洗脱规律性研究. 化学工程2012, (04).
[11]章结兵; 张小里; 李红亚; 赵彬侠, 固定床不同床深下的米格列醇离子交换性研究. 化学工程2012, (02).
[12]张甜甜; 张小里; 李红亚; 豆坤坤; 王彦雄, 大豆磷脂制备甘油磷脂酰胆碱均相催化反应研究. 应用化工2012, (04).
[13]王彦雄; 张小里; 李红亚; 豆坤坤; 张甜甜; 姚娜, 蓖麻油催化裂解制备癸二酸的清洁工艺研究. 工业催化2012, (04).
[14]刘媛媛; 张小里; 姚娜; 李红亚; 赵彬侠, 磷脂酶D的紫外诱变选育及发酵条件的优化. 化工进展2012, (09).
[15]章结兵; 张小里; 李红亚; 赵彬侠; 熊柱, 米格列醇在大孔D001树脂上的离子交换性研究. 化学工程2011, (08).
[16]姚娜; 张小里; 赵彬侠; 王彦雄; 张耀中; 李红亚; 章结兵, 磷脂酶D催化大豆磷脂合成磷脂酰丝氨酸工艺. 化工进展2011, (S1).
[17]艾先立; 赵彬侠; 张小里; 罗晋朝, Fe/AC催化湿式过氧化氢氧化处理焦化废水. 环境工程学报2011, (08).
[18]章结兵; 周安宁; 张小里, 溶胀处理煤对煤结构与煤基聚苯胺导电性影响. 化学工程2010, (06), 83-86.
[19]贾志华; 张小里; 曹学君; 秦宝福; 刘建党, 复合氮源对土曲霉洛伐他汀生物合成的影响. 西北农林科技大学学报(自然科学版) 2010, (10).
[20]赵彬侠; 张小里; 李红亚; 刘林学; 金奇庭, 湿式氧化吡虫啉农药生产废水的MnO_x-CeO_2催化剂性能研究. 高等学校化学学报2009, (05), 965-970.
[21]张耀中; 赵彬侠; 张小里; 刘林学; 章毅; 曹昕; 路程, Fe2O3/SiO2对异辛醇氧化生成异辛酸反应的催化性能研究. 分子催化2009, (06), 529-533.
[22]王端好; 赵彭花; 薛小波; 蒋德富; 张小里, 甘油诱导氧化葡萄糖酸杆菌山梨醇脱氢酶. 精细化工2009, (01), 18-20.
[23]王端好; 薛小波; 张小里, 氧化葡萄糖酸杆菌的选育及其发酵条件优化. 西北大学学报(自然科学版) 2009, (02), 237-240.
[24]王端好; 孙蓓; 赵彭花; 薛小波; 张小里, 化学生物组合法合成米格列醇及其表征. 化工进展2009, (03), 477-480.
[25]王端好; 周河治; 张小里, 桔青霉生产核酸酶的发酵条件研究. 生物加工过程2008, (02), 33-37.
[26]贾志华; 张小里; 曹学君, 碳源对土曲霉中洛伐他汀生物合成的影响. 化学工程2008, (05), 51-54.
[27]王端好; 张小里, 氧化葡萄糖酸杆菌培养及生物转化性能的研究. 食品科学2007, (10), 332-335.
[28]张小里; 王九成; 傅经国; 陈涛; 王惟娇, 以分子伴侣HSP90为靶位的抗癌药物研究. 世界最新医学信息文摘2003, (06), 896-899.
[29]张小里; 赵彬侠; 夏诏杰; 孙勇; 贾志华, 2L搅拌发酵罐培养重组酵母的研究. 西北大学学报 获奖情况 [1]陕西陕化煤化工集团有限公司，尿素合成CO2压缩系统微生物腐蚀研究
[2]陕西高等学校科学技术奖励，二等奖，含铜废水流化床电沉积处理