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基本信息 The basic information
姓名: 陈兴娟

学院: 医学研究院


学历: 博士研究生毕业

学位: 医学博士


职称: 副教授

职务:


学科: 药学,基础医学





招生信息 Admission Information
招生专业：
硕士研究生：分子药理学、基础药理学
研究方向：
1）离子通道相关疾病的分子机制研究
2）调节离子通道的小分子化合物的研究
* 欢迎具有基础医学、药学、分子生物学等学习背景的同学和从业者报考硕士研究生。



教育经历 Education Experience

2009.9—2012.7： 河北医科大学，分子药理学，博士，导师：张海林
2006.9—2009.7： 河北医科大学，分子药理学，硕士，导师：张海林
2002.9—2006.7： 兰州大学，药学，学士







工作经历 Work Experience

2019.3—至今 西北工业大学医学研究院
2017.6—2018.11 Indiana University School of Medicine, Assistant Research Professor,
2015.8—2017.6 Indiana University School of Medicine，Research Associate;
2012.8—2015.8 Indiana University School of Medicine，博士后，合作导师： Alexander Obukhov









科学研究 Scientific Research
研究方向
TRPC ion channels distribute ubiquitously and mediate Ca²⁺ and Na⁺ ions influx into the cells. Ca²⁺, as one of the most universal and inflexible carriers of intracellular signals, acts as a second messenger to regulate all aspects of cellular processes, beginning with triggering life during fertilization and ending with the perish of cells. Therefore, TRPC channels play important roles in many physiological and pathological mechanisms via regulating the cytosolic Ca²⁺ concentration and cell membrane potential. During these decades, numerous study works are invested on TRP channels. Nevertheless, our understanding of these ion channels in human health and diseases remains elusive. In the last few years, the resolution revolution in cryo-electron microscopy enable the high-resolution structures of TRPC channels, which promote us further understand the channel conduction pathway and the gating mechanism.


The activation of TRPC channels depend on the GPCR-PLC pathway. It was well known that the product of PLC hydrolyzing PIP₂ could stimulate TRPC3/TRPC6/TRPC7, but it is still unknown how PLC pathway activated TRPC1/TRPC4/TRPC5. However, besides PLC, there are multiple factors involving in the regulation of TRPC channels.




主持承担科研项目：
1. 国家自然科学基金青年基金：TRPC通道与创伤性脑损伤促进动脉粥样硬化的关系研究，**，2020-1-1 至 2022-12-31
2. 陕西省自然科学基金青年项目：肾上腺嗜铬细胞中TRPC1对TRPC5和VGCCs的调节作用，S2020-JC-QN-1940，2020-1至2021-12
3. 中央高校基本科研业务费：TRPV1和TRPA1通道相关的雌激素在痛觉减退DPN中保护DRG神经元的作用及机制研究
**QD001, 2019-1 至2021-12






学术成果 Academic Achievements
发表学术论文情况（发表时间）
1 X Chen, R Cao, W Zhong. Host Calcium Channels and Pumps in Viral Infections.Cells 2020, 9(1), 94
2 K L Liang, J O Bursova, F Lam, X Chen, A G Obukhov. Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis. J Vis Exp 2019.
3 S Chelvanambi, S K Gupta, X Chen, B W Ellis, B F Maier, T M Colbert, J Kuriakose, P Zorlutuna, P Jolicoeur, A G Obukhov, M Clauss. HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction Implications for Statin Treatment in HIV Patients. Circ Res 2019; 125: 805-20.
4 X Chen, Y Duan, A M Riley, M A Welch, F A White, M B Grant, A G Obukhov. Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons. Molecules 2019; 24: 775.
5 X Chen, N N Taylor-Nguyen, A M Riley, B P Herring, F A White, A G Obukhov. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation 2019; 16: 21.
6 W Ma, X Chen, R Cerne, S K Syed, J V Ficorilli, O Cabrera, A G Obukhov, A M Efanov. Catechol estrogens stimulate insulin secretion in pancreatic beta-cells via activation of the transient receptor potential A1 (TRPA1) channel. J Biol Chem 2019; 294: 2935-46.
7 S Li, K S Hundal, X Chen, M Choi, D G Ogando, A G Obukhov, J A Bonanno. R125H, W240S, C386R, and V507I SLC4A11 mutations associated with corneal endothelial dystrophy affect the transporter function but not trafficking in PS120 cells. Exp Eye Res 2019; 180: 86-91.
8 X Chen, D Liu, D Zhou, Y Si, D Xu, C W Stamatkin, M K Ghozayel, M S Ripsch, A G Obukhov, F A White, S O Meroueh. Small-molecule CaValpha1CaVbeta antagonist suppresses neuronal voltage-gated calcium-channel trafficking. Proc Natl Acad Sci U S A 2018; 115: E10566-E75.
9 X Chen, M Meroueh, G Mazur, E Rouse, K S Hundal, C W Stamatkin, A G Obukhov. Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling. Sci Rep 2018; 8: 11666.
10 J Zhang, X Chen, Y Xue, N Gamper, X Zhang. Beyond voltage-gated ion channels: Voltage-operated membrane proteins and cellular processes. J Cell Physiol 2018; 233: 6377-85.
11 W Li, X Chen (co-first author), A M Riley, S C Hiett, C J Temm, E Beli, X Long, S Chakraborty, M Alloosh, F A White, M B Grant, M Sturek, A G Obukhov. Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs. Basic Res Cardiol 2017; 112: 54.
12 X Chen, S Qian, A Hoggatt, H Tang, T A Hacker, A G Obukhov, P B Herring, C I Seye. Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arterioscler Thromb Vasc Biol 2017; 37: 75-83.
13 X Chen, W Li, A M Riley, M Soliman, S Chakraborty, C W Stamatkin, A G Obukhov. Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel. J Biol Chem 2017; 292: 898-911.
14 X Chen, W Li, S C Hiett, A G Obukhov. Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries. PLoS One 2016; 11: e**.
15 N Luo, M D Conwell, X Chen, C I Kettenhofen, C J Westlake, L B Cantor, C D Wells, R N Weinreb, T W Corson, D F Spandau, K M Joos, C Iomini, A G Obukhov, Y Sun. Primary cilia signaling mediates intraocular pressure sensation. Proc Natl Acad Sci U S A 2014; 111: 12871-6.
16 S C Hiett, M K Owen, W Li, X Chen (co-first author), A Riley, J Noblet, S Flores, M Sturek, J D Tune, A G Obukhov. Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res 2014; 103: 607-18.
17 X Chen, C Egly, A M Riley, W Li, P Tewson, T E Hughes, A M Quinn, A G Obukhov. PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity. Cells 2014; 3: 247-57.
18 X Chen, W Sun, N G Gianaris, A M Riley, T R Cummins, J C Fehrenbacher, A G Obukhov. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem 2014; 289: 9600-10.
19 B Guan, X Chen, H Zhang. Two-electrode voltage clamp. Methods Mol Biol 2013; 998: 79-89.
20 H Gao, X Chen, X Du, B Guan, Y Liu, H Zhang. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium 2011; 50: 559-68.
21 X Chen, X Zhang, C Jia, J Xu, H Gao, G Zhang, X Du, H Zhang. Membrane depolarization increases membrane PtdIns(4,5)P2 levels through mechanisms involving PKC betaII and PI4 kinase. J Biol Chem 2011; 286: 39760-7.
22 C Jia, J Qi, F Zhang, Y Mi, X Zhang, X Chen, L Liu, X Du, H Zhang. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology 2011; 87: 297-310.
23 X Zhang, X Chen (co-first author), C Jia, X Geng, X Du, H Zhang. Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms. J Biol Chem 2010; 285: 9402-9.