Wang, Chan1; Qi, Longbin2; Liang, Rongning2
发表期刊ANALYTICAL METHODS
ISSN1759-9660
2021-02-07
卷号13期号:5页码:620-625
DOI10.1039/d0ay02100h
英文摘要Polymeric membrane potentiometric sensors based on molecularly imprinted polymers (MIPs) have been successfully designed for the detection of organic compounds both in ionic and neutral forms. However, most of these sensors are based on the non-covalent recognition interactions between the functional groups of the MIP in the polymeric sensing membrane and the target. These weak non-covalent interactions are unfavorable for the detection of hydrophilic organic compounds (e.g., dopamine). Herein novel MIP potentiometric sensor based covalent recognition for the determination of protonated dopamine is described. Uniform-sized boronate-based MIP beads are utilized as the recognition receptors. These receptors can covalently bind with dopamine with a cis-diol group to form a five-membered cyclic ester and thus provide a higher affinity because of the stronger nature of the covalent bonds. It has been found that the proposed electrode shows an excellent sensitivity towards dopamine with a detection limit of 2.1 mu M, which could satisfy the needs for in vivo analysis of dopamine in the brain of living animals. We believe that the covalent recognition MIP-based sensing strategy provides an appealing way to design MIP-based electrochemical and optical sensors with excellent sensing properties.
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21874151]; Youth Innovation Promotion Association of CAS [2014190]; Taishan Scholar Program of Shandong Province [tspd20181215]
收录类别SCI
语种英语
研究领域[WOS]Chemistry; Food Science & Technology; Spectroscopy
WOS记录号WOS:000617018900004
引用统计被引频次：3[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/30513
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
作者单位1.Chinese Acad Sci, Yantai Ctr Shandong Integrated Technol Transfer C, Yantai 264003, Shandong, Peoples R China;
2.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, YICCAS,Yantai Inst Coastal Zone Res YIC, Yantai 264003, Shandong, Peoples R China
推荐引用方式
GB/T 7714Wang, Chan,Qi, Longbin,Liang, Rongning. A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine[J]. ANALYTICAL METHODS,2021,13(5):620-625.
APAWang, Chan,Qi, Longbin,&Liang, Rongning.(2021).A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine.ANALYTICAL METHODS,13(5),620-625.
MLAWang, Chan,et al."A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine".ANALYTICAL METHODS 13.5(2021):620-625.
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