Huang, Yan1; Yu, Lei2; Lu, Pengpeng1; Wei, Yinghui4; Wang, Xiaoyan1,3; Chen, Lingxin1,3,5
发表期刊SENSORS AND ACTUATORS B-CHEMICAL
2021-10-01
卷号344页码:8
关键词Fluorescent probeChemotherapyBreast cancerFluorescence imaging
DOI10.1016/j.snb.2021.130233
通讯作者Huang, Yan(yhuang@yic.ac.cn); Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要The incidence rate of breast cancer ranks first in women malignant tumors worldwide, accompanied by a high mortality. The early diagnosis and therapy are important way to reduce the mortality rate of breast cancer in clinical practice. There are urgent needs for anti-tumor strategies with clear evidence and reliable efficacy. Because cytochrome P450 1A1 (CYP1A1) is commonly expressed in breast cancer and has the excellent ability to metabolize xenobiotics, researchers are interested in studying the vital function of CYP1A1 in breast cancer. Herein, we report a BCy-CYP fluorescent probe for imaging of CYP1A1 in cells and in vivo. This probe has outstanding selectivity and high sensitivity for CYP1A1 detection over other biomolecules. Our results reveal that the intracellular CYP1A1 level increase in MCF-7 and MDA-MB-231 cells, and inhibition of CYP1A1 by carnosol efficiently induce apoptosis in the two kinds of breast cancer cells. Thus, CYP1A1 plays a crucial role in breast cancer. The synergistic effect of carnosol and chemotherapy drug is better than chemotherapy drug alone in tumor-bearing mice. CYP1A1 level may be a new biomarker for breast cancer early diagnosis.
资助机构National Nature Science Foundation of China; science and technology innovation development plan of Yantai of China; Binzhou Medical University; Taishan Scholar Project Special Funding; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization; Weifang Science and technology development project
收录类别SCI
语种英语
关键词[WOS]CELL-CYCLE ARREST; EXPRESSION; CYP1A1; DESIGN; AGGREGATION; MECHANISMS; STRATEGIES; CISPLATIN; CARNOSOL; DRUG
研究领域[WOS]Chemistry; Electrochemistry; Instruments & Instrumentation
WOS记录号WOS:000679289000004
引用统计被引频次：1[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29525
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Huang, Yan; Chen, Lingxin作者单位1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
2.Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
5.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714Huang, Yan,Yu, Lei,Lu, Pengpeng,et al. Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe[J]. SENSORS AND ACTUATORS B-CHEMICAL,2021,344:8.
APAHuang, Yan,Yu, Lei,Lu, Pengpeng,Wei, Yinghui,Wang, Xiaoyan,&Chen, Lingxin.(2021).Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe.SENSORS AND ACTUATORS B-CHEMICAL,344,8.
MLAHuang, Yan,et al."Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe".SENSORS AND ACTUATORS B-CHEMICAL 344(2021):8.
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