Song, Junlin1; Wang, Chunde1,2
发表期刊GENOMICS
ISSN0888-7543
2021-07-01
卷号113期号:4页码:2839-2846
关键词TranscriptomicVPS29Carotenoid depositionmRNA
DOI10.1016/j.ygeno.2021.06.015
通讯作者Wang, Chunde(chundewang2007@163.com)
英文摘要Background: In our previous studies, we demonstrated that the accumulation of carotenoids in QN Orange scallops might be regulated by the vacuolar protein sorting 29 (VPS29) gene. VPS genes are involved in pigments accumulation (including carotenoids) in some species and VPS29 is known as the core component of the membrane transport complex Retromer. However, the possible mechanism of carotenoids accumulation underlying the VPS29 remains unexplored. This study aimed to further elucidate the roles of VPS29 in the carotenoid deposition. Results: Transcriptomic analyses revealed four differentially expressed genes related to carotenoid accumulation, including three down-regulated genes, low-density lipoprotein receptor domain class, scavenger receptor, Niemann Pick C1-like 1, and one up-regulated gene, ATP binding cassette transporter in RNAi group. Results from metabonomic analyses indicated increased profiles of retinol and decreased fatty acids between the RNAi and the control group. Conclusions: It thus speculated that VPS may be related to the accumulation of carotenoids as RNAi of VPS 29 seemed to result in a reduction in pectenolone through the blockage in the absorption of carotenoids and an accelerated cleavage of carotenoids into retinol.
资助机构National Natural Science Foundation; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System; Qingdao Agricultural University Foundation; Shandong Province Natural Science Foundation
收录类别SCI
语种英语
关键词[WOS]BOHAI RED; TRANSPORTERS; EXPRESSION; RECEPTOR; CELLS
研究领域[WOS]Biotechnology & Applied Microbiology; Genetics & Heredity
WOS记录号WOS:000669212300002
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29482
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Wang, Chunde作者单位1.Qingdao Agr Univ, Qingdao 266109, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714Song, Junlin,Wang, Chunde. Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops[J]. GENOMICS,2021,113(4):2839-2846.
APASong, Junlin,&Wang, Chunde.(2021).Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops.GENOMICS,113(4),2839-2846.
MLASong, Junlin,et al."Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops".GENOMICS 113.4(2021):2839-2846.
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