Fang, Sheng-Tao1
; Liu, Xiang-Hong1; Yan, Bing-Fei2; Miao, Feng-Ping1; Yin, Xiu-Li1; Li, Wen-Zuo2; Ji, Nai-Yun1发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
2021-06-25
卷号84期号:6页码:1763-1771
DOI10.1021/acs.jnatprod.1c00021
通讯作者Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要Two new meroterpenoids, aspermeroterpenes D and E (1 and 2), two new ophiobolin-type sesterterpenoids, the C-18 epimers of 18,19-dihydro-18-methoxy-19-hydroxyophiobolin P (6 and 7), and two new drimane-type sesquiterpenoids, 3S-hydroxystrobilactone A (8) and 6-epi-strobilactone A (9), along with 11 known terpenoids (3-5 and 10-17) were isolated from the cultures of the algicolous fungus Aspergillus sp. RR-YLW-12, derived from the red alga Rhodomela confervoides. The structures and relative configurations of new compounds were established by detailed spectroscopic analysis of NMR and HRMS experiments, and the absolute configurations were assigned by X-ray diffraction experiments and comparison of their experimental and calculated ECD spectra. Compound 1 features a rare 6/6/6/6/5 pentacyclic system with a meroterpenoid skeleton, and the structure of terretonin E (3) was revised in this study. Compound 4 showed significant inhibitory activities against three microalgae, Prorocentrum donghaiense, Heterosigma akashiwo, and Chattonella marina, with IC50 values of 10.5, 5.2, and 3.1 mu g/mL, respectively.
资助机构Natural Science Foundation for Distinguished Young Scholars of Shandong Province; Yantai Program for Science and Technique Development; Youth Innovation Promotion Association of the CAS; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
关键词[WOS]ABSOLUTE-CONFIGURATIONS; SECONDARY METABOLITES
研究领域[WOS]Plant Sciences; Pharmacology & Pharmacy
WOS记录号WOS:000668368800007
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29471
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Ji, Nai-Yun作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Yantai Univ, Chem & Chem Engn Coll, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Fang, Sheng-Tao,Liu, Xiang-Hong,Yan, Bing-Fei,et al. Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(6):1763-1771.
APAFang, Sheng-Tao.,Liu, Xiang-Hong.,Yan, Bing-Fei.,Miao, Feng-Ping.,Yin, Xiu-Li.,...&Ji, Nai-Yun.(2021).Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,84(6),1763-1771.
MLAFang, Sheng-Tao,et al."Terpenoids from the Marine-Derived Fungus Aspergillus sp. RR-YLW-12, Associated with the Red Alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 84.6(2021):1763-1771.
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