Li, Li-Li1,3
; Wang, Yu-Ting1,2,3; Zhu, Li-Meng1,3; Liu, Zheng-Yi1,3; Ye, Chang-Qing2; Qin, Song1,3发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
2020-01-22
卷号10期号:1页码:12
DOI10.1038/s41598-020-58048-w
通讯作者Ye, Chang-Qing(cqye@ntu.edu.cn); Qin, Song(sqin@yic.ac.cn)
英文摘要Societal lifestyle changes, especially increased consumption of a high-fat diet lacking dietary fibers, lead to gut microbiota dysbiosis and enhance the incidence of adiposity and chronic inflammatory disease. We aimed to investigate the metabolic effects of inulin with different degrees of polymerization on high-fat diet-fed C57BL/6J mice and to evaluate whether different health outcomes are related to regulation of the gut microbiota. Short-chain and long-chain inulins exert beneficial effects through alleviating endotoxemia and inflammation. Antiinflammation was associated with a proportional increase in short-chain fatty acid-producing bacteria and an increase in the concentration of short-chain fatty acids. Inulin might decrease endotoxemia by increasing the proportion of Bifidobacterium and Lactobacillus, and their inhibition of endotoxin secretion may also contribute to antiinflammation. Interestingly, the beneficial health effects of long-chain inulin were more pronounced than those of short-chain inulin. Long-chain inulin was more dependent than short-chain inulin on species capable of processing complex polysaccharides, such as Bacteroides. A good understanding of inulin-gut microbiota-host interactions helps to provide a dietary strategy that could target and prevent high-fat diet-induced endotoxemia and inflammation through a prebiotic effect.
资助机构Youth Innovation Promotion Association of Chinese Academy of Sciences; National Key R&D Program of China
收录类别SCI
语种英语
关键词[WOS]LIPID-METABOLISM; PREBIOTICS; FRUCTANS; RATS; OLIGOSACCHARIDES; MODULATION; GLUCOSE; OBESITY
研究领域[WOS]Science & Technology - Other Topics
WOS记录号WOS:000559822200002
引用统计被引频次：18[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28552
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Ye, Chang-Qing; Qin, Song作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714Li, Li-Li,Wang, Yu-Ting,Zhu, Li-Meng,et al. Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice[J]. SCIENTIFIC REPORTS,2020,10(1):12.
APALi, Li-Li,Wang, Yu-Ting,Zhu, Li-Meng,Liu, Zheng-Yi,Ye, Chang-Qing,&Qin, Song.(2020).Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice.SCIENTIFIC REPORTS,10(1),12.
MLALi, Li-Li,et al."Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice".SCIENTIFIC REPORTS 10.1(2020):12.
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