Chen, Lizhu1; Li, Bin1; Hu, Shunxin1; Qiao, Ruiguang1; Sun, Chunxiao1; Yang, Dinglong2,3,4
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
2020-09-01
卷号104页码:133-140
关键词FAIMRuditapes philippinarumNF-kappa BApoptosis
DOI10.1016/j.fsi.2020.05.058
通讯作者Yang, Dinglong(dlyang@yic.ac.cn)
英文摘要In the present study, a fas apoptotic inhibitory molecule (FAIM) was identified from Ruditapes philippinarum (designated as RpFAIM). Multiple alignments and phylogenetic analysis strongly suggested that RpFAIM was a new member of the FAIMs family. The RpFAIM transcripts were constitutively expressed in a wide range of tissues, and dominantly expressed in hemocytes. After V. anguillarum or M. luteus challenge, the expression level of RpFAIM transcripts was significantly induced and reached the maximum level at 6 h and 24 h, respectively. Knockdown of RpFAIM down-regulated the transcript levels of NF-kappa B signaling genes (e.g. RpIKK, RpI kappa B, RpNF-kappa B). The results were roughly similar to those under bacterial stimulation. Moreover, RpFAIM primarily localized in the cell cytoplasm, and its over-expression inhibited the apoptosis of HeLa cells. These results revealed that RpFAIM perhaps regulated the NF-kappa B signaling pathways positively, which provided a better understanding of RpFAIM in innate immunity.
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences; National Natural Science Foundation of China; Youth Innovation Promotion Association of the Chinese Academy of Sciences
收录类别SCI
语种英语
关键词[WOS]MEDIATED APOPTOSIS; CASPASE ACTIVATION; AKT ACTIVATION; LONG FORM; EXPRESSION; FAIM; DISEASE
研究领域[WOS]Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
WOS记录号WOS:000564750000003
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28528
专题海岸带生物学与生物资源利用重点实验室
支撑部门_中国科学院牟平海岸带环境综合试验站
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Yang, Dinglong作者单位1.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China
4.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714Chen, Lizhu,Li, Bin,Hu, Shunxin,et al. A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis[J]. FISH & SHELLFISH IMMUNOLOGY,2020,104:133-140.
APAChen, Lizhu,Li, Bin,Hu, Shunxin,Qiao, Ruiguang,Sun, Chunxiao,&Yang, Dinglong.(2020).A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis.FISH & SHELLFISH IMMUNOLOGY,104,133-140.
MLAChen, Lizhu,et al."A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis".FISH & SHELLFISH IMMUNOLOGY 104(2020):133-140.
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