Li, Lili1,2
; Wang, Yuting1,2,3; Yuan, Jingyi1,2,4; Liu, Zhengyi1,2; Ye, Changqing3; Qin, Song1,2发表期刊APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
2020-10-19
页码15
关键词Undaria pinnatifidaHyperlipidemiaAdiposityGut microbiotaMetabolomeHigh-fat diet
DOI10.1007/s00253-020-10954-9
通讯作者Ye, Changqing(cqye@ntu.edu.cn); Qin, Song(sqin@yic.ac.cn)
英文摘要Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweedUndaria pinnatifidatreatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation.U. pinnatifidaadministration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity.U. pinnatifidaintake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects ofU. pinnatifidaon high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such asBacteroides acidifaciensandBacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management.
资助机构Youth Innovation Promotion Association of Chinese Academy of Sciences; Science and Technology Program of Yantai
收录类别SCI
语种英语
关键词[WOS]INSULIN-RESISTANCE; FIBER; ACIDS; SUPPLEMENTATION; METABOLITES; SEAWEED; EXTRACT; IMPACT; CANCER; MASS
研究领域[WOS]Biotechnology & Applied Microbiology
WOS记录号WOS:000580713400002
引用统计被引频次：4[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28447
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Ye, Changqing; Qin, Song作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
3.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China
4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Li, Lili,Wang, Yuting,Yuan, Jingyi,et al. Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020:15.
APALi, Lili,Wang, Yuting,Yuan, Jingyi,Liu, Zhengyi,Ye, Changqing,&Qin, Song.(2020).Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,15.
MLALi, Lili,et al."Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020):15.
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