Li, XD; Li, XM; Yin, XL
; Li, X; Wang, BG发表期刊MARINE DRUGS
2019-10
卷号17期号:10页码:563
关键词deep-sea sediment-derived fungusAspergillus versicolorbisabolane-type sesquiterpenoidsmonoterpenoidsantimicrobial activity
研究领域Chemistry, Medicinal
DOI10.3390/md17100563
产权排序[Li, Xiao-Dong; Li, Xiao-Ming; Li, Xin; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China; [Li, Xiao-Dong; Yin, Xiu-Li] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China; [Li, Xiao-Ming; Li, Xin; Wang, Bin-Gui] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China; [Li, Xiao-Ming; Li, Xin; Wang, Bin-Gui] Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
通讯作者Li, Xin(lixin@qdio.ac.cn); Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
作者部门支撑部门
英文摘要Two new antimicrobial bisabolane-type sesquiterpenoid derivatives, ent-aspergoterpenin C (compound 1) and 7-O-methylhydroxysydonic acid (2), and two new butyrolactone-type monoterpenoids, pestalotiolactones C (3) and D (4), along with a known monoterpenoid pestalotiolactone A (5) and four known bisabolane sesquiterpenoids (6-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of the new compounds 1-4 were determined by the combination of NOESY and TDDFT-ECD calculations and X-ray crystallographic analysis. Additionally, we first determined and reported the absolute configuration of the known monoterpenoid pestalotiolactone A (5) through the X-ray crystallographic experiment. All of these isolated compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2, 6 and 9 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and V. harveyi, with MIC values ranging from 1.0 to 8.0 mu g/mL.
文章类型Article
资助机构Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA22050401]; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31700043]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2016LH00033, 2017M612358, 2017M612360]; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences [KEXUE2018G28]; Taishan Scholar Project from Shandong Province; Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017BB073]
收录类别SCI
语种英语
关键词[WOS]BISABOLANE SESQUITERPENES; SECONDARY METABOLITES; ENDOPHYTIC FUNGUS; SYDONIC ACID; A-D; ALKALOIDS
研究领域[WOS]Chemistry, Medicinal
WOS记录号WOS:000498064500023
引用统计被引频次：13[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24841
专题支撑部门
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China;
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China;
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
推荐引用方式
GB/T 7714Li, XD,Li, XM,Yin, XL,et al. Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330[J]. MARINE DRUGS,2019,17(10):563.
APALi, XD,Li, XM,Yin, XL,Li, X,&Wang, BG.(2019).Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330.MARINE DRUGS,17(10),563.
MLALi, XD,et al."Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330".MARINE DRUGS 17.10(2019):563.
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