个人简历

基本信息
单刚，博士，山东大学药学院教授，药物化学专业博士生导师。2019年获得山东大学“齐鲁青年****”称号。
电话: **
邮箱: gangshan@sdu.edu.cn
通讯地址：山东省济南市文化西路44号，山东大学药学院


工作经历



2019.06 – 至今 山东大学药学院， 药物化学专业， 教授、博士生导师
2018.04 – 2019.04 博士后
哈佛大学医学院丹娜法伯癌症研究所
（Dana Farber Cancer Institute）
2015.09 – 2018.04 博士后
德国马普分子生理学研究所
(Max Planck Institute of Molecular Physiology)

教育背景

2010.09 – 2015.07 清华大学药学院 博士

2006.09 – 2010.07 山东大学药学院 学士

主要研究方向

1. 基于活性天然产物的药物化学研究；
2. 小分子化合物库的构建、表型筛选与靶点鉴定；
3. 基于肿瘤ROS和Hypoxia的药物化学研究。


承担课题

山东大学“齐鲁青年****”科研启动基金

论文

1. G. Shan, J. Flegel, H. Li, C. Merten, S. Ziegler, A. P. Antonchick, H. Waldmann.* "C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Novel Hedgehog Pathway Inhibitors " Angew. Chem. Int. Ed. 2018, 57, 14250-14254.
2. Z. Jia, G. Shan, C. G. Daniliuc, A. P. Antonchick, H. Waldmann.* "Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis" Angew. Chem. Int. Ed. 2018, 57, 14493-14497.
3. X.L. Yang⁺, G. Shan⁺, Z. Yang, G. Huang, C. Sheng, Y. Rao.* "One-pot Synthesis of Quaternary Carbon Centered Cyclobutanes via Pd(II)-catalyzed Cascade C(sp³)-H Activations" Chem. Comm. 2017, 53, 1534-1537.
4. X.L. Yang⁺, G. Shan⁺, L. Wang, Y. Rao.* " Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups" Tetrahedron Lett. 2016, 56, 819-836.
5. G. Shan, G. Huang, Y. Rao,* H. Zhang.* "Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones" Chin. Chem. Lett. 2015, 26, 1236-1240.
6. G. Shan, G. Huang, Y. Rao.* "Palladium-Catalyzed Unactivated β-Methylene C(sp³)-H Bond Alkenylation of Aliphatic Amides and Application in A Sequential C(sp³)-H/C(sp²)-H Bond Alkenylation" Org. Biomol. Chem. 2015, 13, 697-701.
7. S. Chen, G. Shan, P. Nie, Y. Rao.* "3-Alkyloxycyclobutanones as Useful Synthons for Heterocycle and Carbocycle Synthesis" Asian J. Org. Chem. 2015, 4, 16-26.
8. Y. Rao*, G. Shan, X. Yang. "Some Recent Advances in Transition-metal-catalyzed ortho SP² C–H Functionalization Using Ru, Rh, and Pd" Science China Chemistry, 2014, 57, 930-944.
9. X. Yang⁺, G. Shan⁺, Y. Rao.* "Synthesis of 2-Aminophenols and Heterocycles by Ru Catalyzed Mono- and Double C-H Hydroxylation" Org. Lett. 2013, 15, 2334-2337.
10. G. Shan, X. Han, Y. Lin, S. Yu, Yu Rao.* "Broadening the Catalyst and Reaction Scope of Regio- and Chemoselective C-H Oxygenation: A Convenient and Scalable Approach to 2-Acylphenols by Intriguing Rh(II) and Ru(II) Catalysis " Org. Biomol. Chem. 2013, 11, 2318-2322.
11. G. Shan⁺, X. Yang⁺, Y. Zong, Y. Rao.* "An Efficient Palladium Catalyzed C-H Alkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine (I³⁺) Oxidants" Angew. Chem. Int. Ed. 2013, 52, 13606-13610.
12. X. Sun⁺, G. Shan⁺, Y. Sun, Y. Rao.* "A General Approach for Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and A Preliminary Study of Priority Order of Relative Directing Group Ability" Angew. Chem. Int. Ed. 2013, 52, 4440-4444.
13. G. Shan, X. Yang, L. Ma, Y. Rao.* "Pd-Catalyzed C-H Oxygenation with TFA/TFAA: Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification" Angew. Chem. Int. Ed. 2012, 51, 13070-13074.
14. Pengfei Liu, Gang Shan, Shi Chen, Y. Rao.* "A New Regio- and Stereoselective Synthesis of β- Enamino Ketones with 3-Ethoxycyclobutanones and Substituted Amines" Tetrahedron Lett. 2012, 53, 936-939.
15. G. Shan, X. Sun, Q. Xia, Y. Rao.* "A Facile Synthesis of Substituted 2-Alkylquinolines Through [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature" Org. Lett. 2011, 13, 5770-5773.
16. G. Shan, P. Liu, Y. Rao.* "A New Synthesis of Pyrazoles through Lewis Acid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines" Org. Lett. 2011, 13, 1746-1749.