余志义，博士，山东大学药学院教授，药物化学及分子药理学专业博士生导师。2018年获得山东大学“齐鲁青年****”称号。
Tel: +86-**
Email: zhiyi_yu@sdu.edu.cn
通讯地址：山东省济南市文化西路44号，山东大学药学院
研究领域
1. 钾离子通道变构调节剂的发现、优化及其转化应用研究
2. 以半胱氨酸环受体(Cys-loop receptors)为靶点的新型神经系统类药物的设计、合成及其药理活性研究
3. 药物与靶标蛋白相互作用的动力学常数(如: residence time, k_on, k_off等)测定及其药理学机制研究
4. 基于分子探针、蛋白质组学以及计算机模拟技术的药物靶点(target deconvolution)及其活性结合位点(binding site identification)的鉴定
工作及学习经历
2019.06 - 至今， 山东大学药学院， 药物化学系， 教授、博士生导师
2015.10 - 2019.06，美国哈佛大学医学院， 神经生物系， 博士后研究员
2011.09 - 2015.10，荷兰莱顿大学药物研究中心， 药物化学及分子药理学专业， 博士
2008.09 - 2011.06，四川大学华西药学院， 药物化学专业， 硕士
2004.09 - 2008.06，四川大学华西药学院， 药学专业， 学士
承担课题
1. 山东大学“齐鲁青年****”科研启动基金
2. 国家自然科学基金青年科学基金项目 hERG钾离子通道变构调节剂的发现、优化及药理活性研究 2020.01-2022.12
代表性学术论文(限10篇)
1. Z. Yu, D.C. Chiara, P.Y. Savechenkov, K.S. Bruzik KS, J.B. Cohen, A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor, Journal of Biological Chemistry, 294(19): 7892-7903 (2019)
2. M. McGrath, Z. Yu, S.S. Jayakar, C. Ma, M. Tolia, X. Zhou, K.W. Miller, J.B. Cohen, D.E. Raines, Etomidate and etomidate analog binding and positive modulation of γ-aminobutyric acid type A receptors: Evidence for a state-dependent cutoff effect, Anesthesiology 129(5):959-969 (2018)
3. L. Sala, Z. Yu, D. Ward-van Oostwaard, J.P. van Veldhoven, A. Moretti, K.-L. Laugwitz, C.L. Mummery, A.P. IJzerman, M. Bellin, A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells, EMBO Molecular Medicine 8(9):1065-1081 (2016)
4. Z. Yu, J.B. Cohen, Enantiomeric barbiturates bind distinct inter- and intra-subunit binding sites in a nicotinic acetylcholine receptor (nAChR), Journal of Biological Chemistry 292(42):17258-17271 (2017)
5. Z. Yu, J. Liu, J.P. van Veldhoven, A.P. IJzerman, M.J. Schalij, D.A. Pijnappels, L.H. Heitman, A.A. de Vries, Allosteric modulation of K_v11.1(hERG) channels protects against drug-induced ventricular arrhythmias, Circulation: Arrhythmia and Electrophysiology 9(4):e003439 (2016)
6. Z. Yu, J.P. van Veldhoven, J. Louvel, I.M. ’t Hart, M.B. Rook, M.A. van der Heyden, L.H. Heitman, A.P. IJzerman, Structure-affinity relationships (SARs) and structure-kinetics relationships (SKRs) of K_v11.1 blockers, Journal of Medicinal Chemistry 58(15):5916-5929 (2015)
7. Z. Yu, J.P. van Veldhoven, I. ME't Hart, A.H. Kopf, L.H. Heitman, A.P. IJzerman, Synthesis and biological evaluation of negative allosteric modulators of the K_v11.1(hERG) channel, European Journal of Medicinal Chemistry 106:50-59 (2015)
8. Z. Yu, A.P. IJzerman, L.H. Heitman, K_v11.1(hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical K_v11.1(hERG) inhibitors, British Journal of Pharmacology 172(3):940-955 (2015)
9. Z. Yu, E. Klaasse, L.H. Heitman, A.P. IJzerman, Allosteric modulators of the hERG K⁺ channel: Radioligand binding assays reveal allosteric characteristics of dofetilide analogs, Toxicology and Applied Pharmacology 274(1):78-86 (2014)
10. Z. Yu, G. Shi, Q. Sun, H. Jin, Y. Teng, K. Tao, G. Zhou, W. Liu, F. Wen, T. Hou, Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl) quinoline-3-carboxylic acid derivatives, European Journal of Medicinal Chemistry 44(11):4726-4733 (2009)