刘相国 电 话：** 传 真： E-Mail：xgliu@sdu.edu.cn

教育背景

起止时间 毕业院校 专业

博士 1997.9-2000.7 中国科学院微生物研究所 微生物学

硕士 1994.9-1997.7 山东大学生命科学学院 细胞生物学

本科 1990.9-1994.7 山东大学生物系 生物学

工作经历

2008.10-现在 山东大学生命科学学院 教授

2003.9-2008.10 美国Emory大学Winship癌症研究所 博士后

2002.11-2003.8 美国Florida大学医学院 博士后

2000.9-2002.11 北京大学医学部基础医学院 博士后

科研方向

1.肿瘤细胞凋亡和自噬的分子机制

2.肿瘤细胞转移的分子机制

3.抗肿瘤药物筛选及作用机制研究

奖励和荣誉

1. 教育部新世纪优秀人才，2009

2. 山东省自然科学杰出青年基金，2010

代表性论文

1. Li T, Su L, Zhong N, Hao X, Zhong D, Singhal S, Liu X*. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9:1057-1068.

2. Yang L, Su L, Cao C, Xu L, Zhong D, Xu L*, Liu X*. The chalcone 2'-hydroxy- 4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells. IUBMB Life. 2013; 65:533-43.

3. Xu L, Su L, Liu X*. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012; 11:2174-82.

4. Liu G, Su L, Hao X, Zhong N, ZHong D, Singhal S, Liu X*. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012;16:1618-28.

5. Su L, Liu G, Hao X, Zhong N, Zhong D, Liu X*, Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer. 2011;47:2471-8.

6. Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007;67:4981-8.

7. Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006; 66:11115-9.

8. Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005; 65: 9169-75.

9. Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004; 96: 1769-80.

10. Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004; 64: 5078-83.