徐志刚 电 话：** 传 真： E-Mail：xuzg(AT)sdu.edu.cn

教育背景

起止时间 毕业院校 专业

博士 1998.09 - 2004.01 复旦大学 遗传学

本科 1995.09 - 1998.07 烟台大学 生物化学

工作经历

2004.01–2004.12 中国国家人类基因组南方研究中心 科研人员

2005.01–2005.09 美国哈佛大学医学院 博士后

2005.10–2009.05 美国斯坦福大学医学院 博士后

2009.05–现在 山东大学生命科学学院 教授

科研方向

1. 听觉传导分子机制

2. 听纤毛发育及维持机制

3. 耳聋发生机制及防护

主持课题

1. 2011.01 – 2013.12 听纤毛蛋白NWK在听觉传导中的功能研究 国家自然科学基金面上项目

2. 2011.01 – 2013.12 MAGI-1在听觉传导中的功能研究 教育部高等学校博士学科点专项科研基金资助课题（博导类）

3. 2011.01 – 2015.08 感音性耳聋发病机制及干预措施的基础研究 国家重点基础研究发展计划（骨干）

4. 2014.01 – 2017.12 Sorting Nexin 9 (SNX9)在听毛细胞表皮板中的功能研究 国家自然科学基金面上项目

研究成果

1. Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG*, Sun JP*. Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J Biol Chem. 2014 Jun 24. pii: jbc.M114.549816. (SCI, 5-year-impact 5.02)

2.Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S, Xu Z*. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. PLoS ONE. 2013; 8(2): e56516. (SCI, 5-year-impact 4.24)

3. Sun J*, Li R, Ren H, Xu A, Yu X, Xu Z*. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. 2013; 50:204–14. (SCI, 5-year-impact 2.66)

4. Li H, Liu N, Wang S, Wang L, Zhao J, Su L, Zhang Y, Zhang S, Xu Z*, Zhao B*, Miao J*. Identification of a small molecule targeting annexin A7. Biochim Biophys Acta – Molecular Cell Research. 2013 Sep; 1832(9):2092-9. (SCI, 5-year-impact 4.95)

5. Xu Z*, Oshima K, Heller S. PIST regulates the intracellular trafficking and plasma membrane expression of Cadherin 23. BMC Cell Biology 2010; 11:80. (SCI, 5-year-impact 3.08)

6．Xu Z¹, Ricci AJ, Heller S. Rethinking how hearing happens. Neuron 2009; 62(3):305-7. (SCI, 5-year-impact 16.40)

7. Shen HL¹, Xu ZG¹ (Contributed equally), Huang LY, Liu D, Lin DH, Cao JB, Zhang X, Wang ZQ, Wang WH, Yang PY, Han ZG. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. Mol Cell Biochem. 2009; 321(1-2):73-83. (SCI, 5-year-impact 2.19)

8. Xu Z¹, Peng AW, Oshima K, Heller S. MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. J Neurosci. 2008; 28(44):11269-76. (SCI, 5-year-impact 7.87)

9. Xu ZG¹, Du JJ, Cui SJ, Wang ZQ, Huo KK, Li YY, Han ZG. Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. DNA Seq. 2004;15(2):81-7. (SCI, 5-year-impact 0.65)

10. Xu ZG¹, Du JJ, Zhang X, Cheng ZH, Ma ZZ, Xiao HS, Yu L, Wang ZQ, Li YY, Huo KK, Han ZG. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology. 2003;38(3):735-44. (SCI, 5-year-impact 11.40)