刘巍峰 电 话：** 传 真： E-Mail：weifliu@sdu.edu.cn

Name: WEIFENG LIU

Phone: **

Email: weifliu@sdu.edu.cn





EDUCATION

1994.09-1997.06 Ph.D ShandongUniversity

1991.09-1994.06 Master ShandongUniversity

1987.09-1991.09 Bachelor ShandongUniversity



WORK EXPERIENCE

1998.10-2001.02 Massachusette Institute of Technology Postdoc Associate

2002.04-2004.05 Cancer Research UK, London Institute Research Fellow

2001.02-2005.09 Shandong University Associate Professor

2005.09-- ShandongUniversity Professor
RESEARCH INTERST

1. Signal transduction and gene expression regulation in eukaryotic microorganisms;

2. Mechanisms of microbial decomposition of cellulose

3. Genetic resources in uncultivated microorganisms
RESEARCH PROGRAMS

1. Molecular mechanisms of transcriptional activation of cellulase genes in filamentous fungi Trichoderma reesei, National Natural Science Foundation

2. Diversity in microbial degradation of lignocellulose, novel factors and relevant mechanisms, National Basic Research Program of China

3. Mechanisms of regulation of cellulase gene in Trichoderma reesei, New Century Excellent Talents in University

4. Genetics of eukaryotic microorganisms, Shandong Provincial Funds for Distinguished Young Scientists

5. Expression and Mechanism Study of Fungi Expansin-like Swollenin, Internation collaboration with Royal Dutch/Shell Group,Shell.



SELECTED PUBLICATIOS

1. Xinxing Lv, Fanglin Zheng, Chunyan Li, Weixin Zhang, Guanjun Chen and Weifeng Liu*. Characterization of a copper responsive promoter and its mediated overexpression of the Xylanase regulator 1 results in an induction-independent production of cellulases in Trichoderma reesei. Biotechnology for Biofuels 2015.

2. Zhou H, Wang X, Yang T, Zhang W, Chen G, Liu W*. Identification and characterization of a novel locus in Cytophaga hutchinsonii involved in colony spreading and cellulose digestion. Applied Microbiology and Biotechnology 2015 DOI: 10.1007/s00253-015-6412-9

3. Zhang X, Zhong Y, Yang S, Zhang W, Xu M, Ma A, Zhuang G, Chen G, Liu W*. Diversity and dynamics of the microbial community on decomposing wheat straw during mushroom compost production. Bioresource Technology 2014, 17:183-195

4. Xu J，Zhao G, Kou Y, Zhang W, Zhou Q, Chen G, Liu W*. Intracellular β-glucosidases CEL1aand CEL1b are essential for cellulase induction on lactose in Trichoderma reesei. Eukaryotic Cell 2014, 13(8):1001-1013

5. Qi F, Zhang W, Zhang F, Chen G, Liu W*.　Deciphering the effect of the different N-glycosylation sites on the secretion, activity and stability of cellobiohydrolase I from Trichoderma reesei. Applied and Environmental Microbiology 2014, 80 (13): 3962-3971

6. Kou YB, Xu JT,Cao YL, Lv XX, Zhao GL, Chen GJ, Zhang WX*, Liu WF. Gluconolactone induces cellulase gene expressionin cellulolytic filamentous fungus Trichoderma reesei. RSC Advances 2014, 4:36057-36063.

7. Zhang W, Kou Y, Xu J,Cao Y, Zhao G, Shao J, Wang H, Wang Z, Bao X, Chen G, Liu W*. Two Major Facilitator Superfamily Sugar Transporters from Trichoderma reesei and Their Roles in Induction of Cellulase Biosynthesis. Journal of Biological Chemistry 2013, 288:32861-32872.

8. Xin Q, Gong Y, Lv X, Chen G, Liu W*. Trichoderma reesei Histone Acetyltrans ferase Gcn5 Regulates Fungal Growth, Conidiation, and Cellulase Gene Expression. Current Microbiology 2013, 67(5):500-589.

9. Liu G; Zhang L; Qin, Y; Zou G; Li, Z; Yan X; Wei X; Chen M; Chen L; Zheng K; Zhang J; Ma L; Li J; Liu R; Xu H; Bao X; Fang X, Wang L, Zhong Y, Liu W, Zheng H, Wang S, Wang C, Xun L, Zhao GP, Wang T, Zhou Z, Qu Y. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Report 2013, 3:1569 10. Zhu Y, Zhou H, Bi Y, Zhang W, Chen G, Liu W*. Characterization of a family 5 glycoside hydrolase isolated from the outer membrane of cellulolytic Cytophaga hutchinsonii. Appl Microbiol Biotechbol 2013, 97:3925-3937.

11. Zhou Q, Xu J, Kou Y, Lv X，Zhang X, Zhao G，Zhang W, Chen G, Liu W*. Differential involvement of β-glucosidases from Hypocrea jecorina in rapid induction of cellulase genes by cellulose and cellobiose. Eukaryotic cell 2012, 11: 1371-1381.

12. Li Y, Chen G, Liu WF*. Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcription activator Gal4p. Molecular Microbiology 2010, 78(2): 414-428.

13. Yu S, Zhang X, Chen G, Liu W*. Compromised cellular responses to DNA damage accelerate chronological aging by incurring cell wall fragility in Saccharomyces cerevisiae. Mol Biol Rept 2012, 39(4):3573-3583.

14. Zhu Y, Li HH, Zhou H, Chen GJ, Liu WF*. Cellulose and cellodextrin utilization by the cellulolytic bacterium Cytophaga hutchisonii. Bioresource Technology 2010, 101:6432-6437.

15. Ge X, Wang K, Bo T, Kou YB, Liu WF*, Chen GJ. Magnetospirillum magneticum AMB-1 peroxiredoxins contribute to the aerotolerance and genetic stability of the genomic magnetosome island. FEMS Microbiology Letters 2011, 320(2):118-27.

16. Li Y, Chen G, Liu W*. Alterations in the Interaction Between GAL4 and GAL80 Effect Regulation of the Yeast GAL Regulon Mediated by the F box Protein Dsg1. Current Microbiology 2010, 61(3):210-216.

17. Yu S, Qin W, Zhuang G, Zhang X, Chen G, Liu W*. Monitoring Oxidative Stress and DNA Damage Induced by Heavy Metals in Yeast Expressing a Redox- Sensitive Green Fluorescent Protein. Curr Microbiol 2009, 58(5):504-510.

18. Zhang X, Chen G, Liu W*. Reduction of xylose to xylitol catalyzed by Glucose- fructose oxidoreductase from Zymomonas mobilis. FEMS Microbiology Letters 2009, 293:214-219.

19. Zhang X, Wang Y, Wang L, Chen G, Liu W*, Gao P. Site-directed mutagenesis of manganese peroxidase from Phanerochaete chrysosporium in an in vitro expression system. J Biotechnol 2009, 139(2):176-178.

20. Wang F, Li F, Chen G, Liu W*. Isolation and characterization of novel cellulase genes from uncultured microorganisms in different environmental niches. Microbiology Research 2009, 164:650-657.



PATENTS

1. Liu W, Zhu Y, Lu X, Chen G.A method for preparing soluble oligo β-1，3-glucansfrom yeasts，No. ZL**8.9.

2. Liu W, Shi W, Zhu Y, Lu X, Chen G. A method to disrupt the yeast cell wall using microbial enzymes, No.ZL**7.X.

3. Lu X, Fan Z, Liu W, Duan F, Zhang C. Microbe producingβ-1，3-glucanases and its apllication，No.**7.7.

4. Zhou Q, Liu　W, Xu J, Lv X, Chen G. β-glucosidase Mutlb and its expression as well as its application，No.**0.5

5. Zhou Q, Liu　W, Chen G, Xu J, Lv X.β-glucosidase Cel1b and its expression as well as its application，No. **9.6