姓名职称：
单世娟 讲师，硕士生导师
教育经历：
2006/09-2010/07 齐鲁工业大学，食品与生物工程学院，本科，生物技术专业。
2011/09-2014/06山东师范大学，生命科学学院，硕士，细胞生物学专业，导师：杨桂文教授。
2014/09-2017/07山东师范大学，生命科学学院，博士，动物学专业，导师：安利国教授
工作经历：
2017/09-至今 山东师范大学，生命科学学院，讲师。
研究兴趣，领域：
研究方向：鱼类天然免疫
开设课程：
本科：细胞工程、免疫学
主持或参加科研项目及人才计划项目情况：
1．鱼类特异TLR18在鲤鱼抗细菌感染免疫中的作用机制研究，2017M622258，中国博士后科学基金面上资助，2017/11-2019/11，5万元，主持。
2．鱼类特异性模式识别受体TLR18的识别特性和作用机制研究，ZR2018BC054，山东省自然科学基金博士基金，2018/03-2020/12，8万元，主持。
3．黄鳝抗细菌病感染的免疫学基础, 2018YFD**，国家重点研发计划子课题，2018.12-2022.12，46万，参与。
4．鲤鱼新型免疫球蛋白IgT粘膜免疫特性及其抗体库多样性研究，**，国家自然科学基金面上项目，2020.1-2023.12，56万元，参与。
代表性论文：
1. Shijuan Shan, Rongrong Liu, Hanxiao Feng, Yonghuan Zhang, Fumiao Zhang, Cui Lv, Guiwen Yang, Identification and functional characterization of the transcription factor NF-κB subunit p65 in common carp (Cyprinus carpio L.), Fish Shellfish Immunol, 2019, 95:25-34.
2. Shijuan Shan, rongrong Liu, Lei Jiang, Yaoyao Zhu, Hua Li, Weixian Xing, Guiwen Yang, Carp Toll-like receptor 8 (Tlr8): An intracellular Tlr that recruits TIRAP as adaptor and activates AP-1 pathway in immune response, Fish & Shellfish Immunology, 2018, 82:41-49
3. Shijuan Shan, Dezhi Liu, Rongrong Liu, Yaoyao Zhu, Ting Li, Fumiao Zhang, Liguo An, Guiwen Yang, Hua Li, Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway, Fish & Shellfish Immunology, 2018, 72: 187-198.
4. Shijuan Shan, Chenchen Qi, Yaoyao Zhu, Hua Li,Liguo An^*, Guiwen Yang^*.Expression profile of carp IFN correlate with the up-regulation of interferonregulatory factor-1 (IRF-1)in vivoandin vitro: the pivotal moleculesin antiviral defense, Fish & Shellfish Immunology, 2016, 52: 94-102.
4.Shijuan Shan^#_, Lei Wang^#,Fumiao Zhang, Yaoyao Zhu, Liguo An^*and Guiwen Yang^*, Characterization and expression analysisof Toll-interacting protein in common carp, Cyprinus carpio L., responding tobacterial and viral challenge, Springerplus, 2016, 5:639.
6.Shijuan Shan, Dezhi Liu, Lei Wang, Yaoyao Zhu, Fumiao Zhang, Ting Li, Liguo An^*and Guiwen Yang^*. Identification and expression analysis ofirak1 gene in common carp Cyprinus carpio L.: indications for a role of antibacterial and antiviral immunity. Journal of Fish Biology, 2015, 87: 241–255.
7.Yaoyao Zhu, Chenchen Qi, Shijuan Shan, FumiaoZhang, Hua Li, Liguo An^*, GuiwenYang^*, Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges, BMC Veterinary Research, 2016, 12:127.
6.Y. Y. Zhu, W. X. Xing, S. J. Shan, S. Q.Zhang, Y. Q. Li, T. Li, L. An^*and G. W. Yang^*, Characterization and immune response expression of the Rig-I-like receptor mda5 in common carp Cyprinus carpio, Journal of Fish Biology, 2016, 88: 2188-2202.
8.Guiwen Yang, HongyanGuo, Hua Li, Shijuan Shan, Xueqing Zhang,Jan H.W.M. Rombout^*, LiguoAn^*. Molecular characterization of LEAP-2 cDNA in common carp(Cyprinus carpio L.) and the differential expression upon a Vibrio anguillarumstimulus; indications for a significant immune role in skin. Fish & Shellfish Immunology. 2014; 37(1): 22-29.
9.Hua Li, Hongyan Guo, Shijuan Shan, Chenchen Qi, Liguo An^* & GuiwenYang^*. Characterization and expression pattern of a novel β-defensin in common carp (Cyprinus carpio L.): implications for its role inmucosal immunity. Bioscience, Biotechnology, and Biochemistry. 2014; (78)(3):430-437.