姓名：王栩


职称：
教授

专业：
分析化学

博(硕)导：
博导

最终学历：
博士

联系电话：

电子邮件：
wangxu@sdnu.edu.cn

简历及研究领域

个人简介：
2000年7月于聊城大学化学化工学院获理学学士学位，2003年7月于山东师范大学化学化工与材料科学学院获理学硕士学位，2006年7月于中国科学院生态环境研究中心获理学博士学位，2006年7月至2008年6月在清华大学化学系从事博士后研究。2008年9月进入山东师范大学化学化工与材料科学学院工作。
主讲课程：《仪器分析化学》(本科专业基础课)、《现代光分析》(研究生必修课)，《分析化学实验》(本科必修课)
研究领域：光学功能探针设计、合成及其诊疗应用；细胞及活体成像。主持完成国家自然科学面上及青年基金、山东省优秀中青年科学家科研奖励基金、教育部博士点基金青年教师基金等国家级、省部级项目多项，目前主持国家自然科学基金面上项目一项，先后参与国家自然科学基金重点项目、重大项目各一项。

代表性论文

近期发表的主要文章：
16.Yong Li, Yingzheng Shu, Xu Wang,* Xiaoyun Jiao, Xilei Xie, Jian Zhang and Bo Tang*, A H₂S-activated Ratiometric CO Photoreleaser Enabled by Excimer/Monomer Conversion, Chem. Commun., 2019, 55, 6301-6304
15.Jian Zhang, Muwen Liang, Xu Wang,* Yong Li, Xiaoyun Jiao, Xilei Xie, and Bo Tang*, Visualizing Peroxynitrite Fluxes in Myocardial Cells by a New Fluorescent Probe Reveals the Protective Effect of Estrogen,
Chem. Commun., 2019, 55, 6719-6722
14. Yong Li, Zhiwen Zhao, Yongsheng Xiao, Xu Wang,* Xiaoyun Jiao, Xilei Xie, Jian Zhang and Bo Tang*, Reactivity modulation of benzopyran-coumarin platform by introducing electron-withdrawing groups: specific detection of biothiols and peroxynitrite, Anal. Chem., 2019, 91, 6097-6102
13. Xilei Xie,*, Guangzhao Liu, Xingxing Su, Yong Li, Yawen Liu, Xiaoyun Jiao, Xu Wang,* and Bo Tang*, A Facile, Versatile, and Highly Efficient Strategy for Peroxynitrite Bioimaging Enabled by Formamide Deformylation, Anal. Chem., 2019, 91, 6872-6879
12.Xilei Xie, Tianhong Wu, Xu Wang,* Yong Li, Kaiye Wang, Zhiwen Zhao, Xiaoyun Jiao and Bo Tang*, Two-photon fluorescent probe for ratiometric visualization of hypochlorous acid in live cells and animals based on selenide oxidation/elimination tandem reaction, Chem. Commun., 2018, 54, 11965-11968
11.Yong Li, Yingzheng Shu, Muwen Liang, Xilei Xie, Xiaoyun Jiao, Xu Wang*, and Bo Tang*,A Two-photon H?O?-activated CO Photoreleaser,Angew. Chem. Int. Ed., 2018, 57, 12415-12419
10.Xilei Xie*,Fuyan Tang,Guangzhao Liu, Yong Li, Xingxing Su, Xiaoyun Jiao, Xu Wang*, and Bo Tang*, Mitochondrial Peroxynitrite Mediates Anthracycline Induced Cardiotoxicity as Visualized by a Two-Photon Near-Infrared Fluorescent Probe, Anal. Chem., 2018, 90, 11629-11635
9. Xiaoyun Jiao, Yongsheng Xiao, Yong Li, Muwen Liang, Xilei Xie, Xu Wang* and Bo Tang*, Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and H2S with a Two-Photon Fluorescent Probe, Anal. Chem., 2018, 90, 7510-7516

8. Xiaoyun Jiao, Yong Li, Jinye Niu, Xilei Xie, Xu Wang^*, Bo Tang^*, Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems, Anal. Chem., 2018, 90, 533-555

7. Xilei Xie, Jilin Fan, Muwen Liang, Yong Li, Xiaoyun Jiao, Xu Wang*, Bo Tang*,A two-photon excitable and ratiometric fluorogenic nitric oxide photoreleaser and its biological applications, Chem. Commun., 2017, 53, 11941 -11944
6. Yong Li, Xilei Xie, Xiu’e Yang, Mengmeng Li, Xiaoyun Jiao, Yuhui Sun, Xu Wang* and Bo Tang*, Two-photon Fluorescent Probe for Revealing Drug-induced Hepatotoxicity via Mapping Fluctuation of Peroxynitrite, Chem. Sci., 2017, 8, 4006-4011
5. Xilei Xie, Fuyan Tang, Xiaoyan Shangguan, Shiyi Che, Jinye Niu, Yongsheng Xiao, Xu Wang* and Bo Tang*, Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe. Chem. Commun., 2017, 53, 6520-6523
4. Jinye Niu, Jilin Fan, Xu Wang*, Yongsheng Xiao, Xilei Xie, Xiaoyun Jiao, Chuan-Zhi Sun, and Bo Tang*, Simultaneous Fluorescence and Chemiluminescence Turned on by Aggregation-Induced Emission for Real-time Monitoring of Endogenous Superoxide Anion in Live Cells. Anal. Chem., 2017, 89, 7210–7215
3. Xilei Xie, Mengmeng Li, Fuyan Tang, Yong Li, Leilei Zhang, Xiaoyun Jiao, Xu Wang,* and Bo Tang*, Combinatorial Strategy to Identify Fluorescent Probes for Biothiol and Thiophenol Based on Diversified Pyrimidine Moieties and Their Biological Applications, Anal. Chem., 2017, 89, 3015?3020
2. Xilei Xie, Xiu’e Yang, Tianhong Wu, Yong Li, Mengmeng Li, Qi Tan, Xu Wang*, and Bo Tang*, Rational Design of an α-Ketoamide-Based Near-Infrared Fluorescent ProbeSpecific for Hydrogen Peroxide in Living Systems, Anal. Chem., 2016, 88, 8019-8025
1.Yong Li,¹ Xu Wang,¹ Jie Yang, Xilei Xie, Mengmeng Li, Jinye Niu, Lili Tong, and Bo Tang*, Fluorescent Probe Based onAzobenzene-Cyclopalladium for the Selective Imaging of Endogenous CarbonMonoxide under Hypoxia Conditions, Anal. Chem., 2016,88, 11154–11159
专利:
3. 唐波，王栩，李勇，解希雷，李萌萌，一种检测细胞内CO的荧光探针及其制备方法和应用，中国发明专利，ZL 1.7
2. 唐波，王栩，孙娟，马晓旭，吕建政，一种检测细胞内硫化氢的荧光探针及其制备方法和应用，中国发明专利：ZL 0.0
1. 林金明，王栩，魏彦林，环境水样在线自动检/监测的水样分配器，中国发明专利：ZL 6.8

著 作：
《化学发光免疫分析》，编著 林金明，赵利霞，王 栩，化学工业出版社，2008年3月。


研究课题

2018.1-2021.12
国家自然科学基金面上项目

2014.1-2017.12
国家自然科学基金面上项目

2010.1-2012.12
国家自然科学基金青年基金

2011.6-2014.6
山东省优秀中青年科学家科研奖励基金

2009.12-2012.12
教育部博士点基金青年教师基金






荣誉称号

2009.11
林金明、应希堂、王 栩、肖勤、张倩云、林珍，2009年中国分析测试协会科学技术（CAIA）奖一等奖

2016.1
唐波，李平，李娜，王栩，山东省自然科学一等奖

2016.12

山东省高等学校科学技术奖二等奖（第一位）


2017.11

山东省青年科技奖