基本资料


职称：
教授

专业：
分析化学

博(硕)导：
博导

最终学历：
博士

联系电话：


电子邮件：
cyzhang@sdnu.edu.cn

简历及研究领域

个人简介：
张春阳，博士，教授，博士生导师，国务院政府特殊津贴专家。1999年在北京大学获博士学位，随后在清华大学完成博士后研究。2001年赴美，先后在埃默里大学、约翰霍普金斯大学和纽约城市大学工作。2009年回国加入中国科学院深圳先进技术研究院，现为山东师范大学化学化工与材料科学学院院长。2011年入选中国科学院“****”， 2013年获国家****科学基金， 2014年入选深圳市“鹏城****”****和广东省"南粤百杰"杰出人才工程， 2015年入选山东省“泰山****”优势特色学科领军人才和科技部创新人才推进计划， 2017年入选国家“****”科技创新领军人才。荣获山东省富民兴鲁劳动奖章和“山东省优秀科技工作者”称号。主要研究方向为单分子检测与成像及其临床应用研究。文章发表在Nature Materials、Journal of the American Chemical Society、Angewandte Chemie International Edition和Analytical Chemistry等国际有影响力杂志，并被Science、Nature、Nature Materials、Analytical Chemistry、Science Daily等国际权威期刊及媒体广泛报道和评论。

代表性论文

1.??Yan Zhang, Wen-jing Xu, Ya-ping Zeng, Chun-yang Zhang*, Sensitive Detection of DNA Methyltransferase Activity by Transcription-Mediated Duplex-Specific
Nuclease-Assisted Cyclic Signal Amplification, Chemical Communications, 2015, 51, 13968-13971.
2.Yan Zhang, Jiao Liu, Chun-yang Zhang*, Real-Time Monitoring of Small Biological Molecules by Ligation-Mediated Polymerase Chain Reaction, Chemical
Communications, 2015, 51, 12270-12273.
3.Li-juan Wang, Yong Yang, Chun-yang Zhang*, Phosphorylation-Directed Assembly of Single Quantum Dot-Based Nanosensor for Protein Kinase Assay,
Analytical Chemistry, 2015, 87, 4696-4703.
4.Qinfeng Xu,Yihong Zhang, Chun-yang Zhang*, A Triple-Color Fluorescent Probe for Multiple Nuclease Assays,Chemical Communications, 2015, 51, 9121-9124.
5.Guichi Zhu, Kun Yang, Chun-yang Zhang*, Single Quantum Dot-Based Biosensor for Telomerase Assay, Chemical Communications, 2015, 51, 6808-6811.
6.Qinfeng Xu,Yan Zhang, Chun-yang Zhang*, A Universal Sensing Platform Based on the Repair Ligation-Mediated Light-Producing DNA Machine, Chemical
Communications, 2015, 51, 5652-5655.
7.Si-qiang Huang, Juan Hu, Guichi Zhu, Chun-yang Zhang*, Sensitive detection of point mutation using exponential strand displacement amplification-based surface
enhanced Raman spectroscopy, Biosensors and Bioelectronics, 2015, 65, 191-197.
8.Yong Yang, Chun-yang Zhang*, Visualizing and Quantifying Protein PolySUMOylation at the Single-Molecule Level, Analytical Chemistry, 2014, 86, 967-972.
9.Fei Ma, Yong Yang, Chun-yang Zhang*, Ultrasensitive Detection of Transcription Factors Using Transcription-mediated Isothermally Exponential Amplification-
Induced Chemiluminescence,Analytical Chemistry, 2014, 86, 6006-6011.
10.Li-rong Zhang, Guichi Zhu, Chun-yang Zhang*, Homogeneous and Label-Free Detection of MicroRNAs Using Bifunctional Strand Displacement Amplification-
Mediated Hyperbranched Rolling Circle Amplification, Analytical Chemistry, 2014, 86, 6703-6709.
11.Jiao Du, Qinfeng Xu, Xiaoquan Lu*, Chun-yang Zhang*, A Label-Free Bioluminescent Sensor for Real-Time Monitoring Polynucleotide Kinase Activity,
Analytical Chemistry, 2014, 86, 8481-8488.
12.Guichi Zhu, Li Liang, Chun-yang Zhang*, A Quencher-free Fluorescent Method for Homogeneously Sensitive Detection of MicroRNAs in Human Lung Tissues, Analytical Chemistry, 2014, 86, 11410-11416.
13.Guichi Zhu, Ying Li, Chun-yang Zhang*, Simultaneous detection of mercury (II) and silver (I) ions with picomolar sensitivity, Chemical Communications,
2014, 50, 572-574.
14.Yan Zhang, Li-juan Wang, Chun-yang Zhang*, Highly sensitive detection of telomerase using telomeres-triggered isothermal exponential amplification- based
DNAzyme biosensor, Chemical Communications, 2014, 50, 1909-1911.
15.Wei Tang, Guichi Zhu, Chun-yang Zhang*, Sensitive detection of polynucleotide kinase using rolling circle amplification-induced chemiluminescence, Chemical
Communications, 2014, 50, 4733-4735.
16.Ya-ping Zeng, Guichi Zhu, Xiao-yun Yang, Jun Cao, Zhi-liang Jing, Chun-yang Zhang*, A quantum dot-based microRNA nanosensor for point mutation assay,
Chemical Communications, 2014, 50,7160-7162.
17.Qinfeng Xu, Chun-yang Zhang*, Riboadenosine-substituted DNA probes for self-illuminating real-time monitoring exonuclease III activity and exonuclease III-
assisted target recycling, Chemical Communications, 2014, 50, 8047-8049.
18.Li-ping Ye, Juan Hu, Li Liang, Chun-yang Zhang*, Surface-enhanced Raman spectroscopy for simultaneously sensitive detection of multiple microRNAs in lung
cancer cells, Chemical Communications, 2014, 50, 11883-11886.
19.Juan Hu, Chun-yang Zhang*, Multiplex Detection of Lung Cancer Cells at the Single-Molecule Level, Chemical Communications, 2014, 50, 13581-13584.
20.Li-juan Wang, Yan Zhang, Chun-yang Zhang*, A Target-Triggered Exponential Amplification-Based DNAzyme Biosensor for Ultrasensitive Detection of Folate
Receptors, Chemical Communications, 2014, 50, 15393-15396.
21.Lin-fei Zhang,Juan Zhou, Chun-yang Zhang*, pH-Controlled growth of ultrathin iron vanadium oxide (FeV3O8) nanoplatelets with high visible-light photo-
catalytic activity, Journal of Materials Chemistry A, 2014, 2 (36), 14903-14907.
22.Ying Li, Wei Tang, Li-rong Zhang, Chun-yang Zhang*, FMRP regulates miR196a-mediated repression of HOXB8 via interaction with AGO2 MID domain,
Molecular BioSystems, 2014, 10 (7), 1757-1764.
23.Lin-fei Zhang, Chun-yang Zhang*, Multifunctional Co0.85Se/Graphene Hybrid Nanosheets: Controlled Synthesis and Enhanced Performances for Oxygen
Reduction Reaction and Decomposition of Hydrazine Hydrate, Nanoscale, 2014, 6, 1782 - 1789.
24.Juan Zhou, Qiangxin Wang, Chun-yang Zhang*, Liposome-Quantum Dot Complexes Enable Multiplexed Detection of Attomolar DNAs without Target
Amplification ,Journal of the American Chemical Society, 2013, 135, 2056-2059.
25.Yong Yang, Chun-yang Zhang*, Simultaneous Measurement of SUMOylation via SNAP/CLIP-Tag-Mediated Translation at Single-Molecule Level, Angewandte Chemie International Edition, 2013, 52, 691-694.
26.Juan Hu, Chun-yang Zhang*, Simple and Accurate Quantification of Quantum Yield at the Single-Molecule/Particle Level, Analytical Chemistry, 2013, 85, 2000-2004.
27.Anping Cao, Chun-yang Zhang*, Real-Time Detection of Transcription Factors Using Target-Converted Helicase-Dependent Amplification Assay with Zero-
Background Signal, Analytical Chemistry, 2013, 85, 2543-2547.
28.Ya-ping Zeng, Juan Hu, Yi Long, Chun-yang Zhang*, Sensitive Detection of DNA Methyltransferase Using Hairpin Probe-Based Primer Generation Rolling
Circle Amplification-Induced Chemiluminescence, Analytical Chemistry, 2013, 85, 6143-6150.
29.Qinfeng Xu, Guichi Zhu, Chun-yang Zhang*, Homogeneous Bioluminescence Detection of Biomolecules Using Target-triggered Hybridization Chain Reaction-
Mediated Ligation without Luciferase label, Analytical Chemistry, 2013, 85, 6915-6921.
30.Ying Li, Li liang, Chun-yang Zhang*, Isothermally Sensitive Detection ofSerum Circulating miRNAs for Lung Cancer Diagnosis, Analytical Chemistry,
2013, 85, 11174-11179.
31.Li-juan Wang, Yan Zhang, Chun-yang Zhang*, Ultrasensitive Detection of Telomerase Activity at the Single-Cell Level, Analytical Chemistry, 2013, 85, 11509-11517.
32.Juan Zhou, Yong Yang, Chun-yang Zhang*, A Low-Temperature Solid-Phase Method to Synthesize Highly Fluorescent Carbon Nitride Dots with Tunable
Emission, Chemical Communications, 2013, 49 (77), 8605-8607.
33.Jun-jie Hao, Juan Zhou, Chun-yang Zhang*, Tri-n-octylphosphine-Assisted Successive Ionic Layer Adsorption and Reaction Method to Synthesize Multilayered
Core/Shell CdSe/ZnS Quantum Dots with Extremely High Quantum Yield, Chemical Communications, 2013, 49 (56), 6346-6348.
34.Lin-fei Zhang, Chun-yang Zhang*, Controlled Growth of Concave Gold Nanobars with High Surface-Enhanced Raman-Scattering and Excellent Catalytic
Activities, Nanoscale, 2013,5, 5794-5800.
35.Lin-fei Zhang, Chun-yang Zhang*, Dodecahedral Au@Pd Nanocrystals with High-Index Facets and Excellent Electrocatalytic Activity and Highly Efficient
Surface-Enhanced Raman Scattering Enhancement, Nanoscale, 2013, 5, 6074-6080.
36.Guichi Zhu, Kun Yang, Chun-yang Zhang*, Sensitive detection of methylated DNA using the short linear quencher-fluorophore probe and two-stage isothermal
amplification assay, Biosensors and Bioelectronics, 2013, 49, 170-175.
37.Qinfeng Xu, Anping Cao, Ling-fei Zhang, Chun-yang Zhang*, Rapid and Label-free Monitoring of Exonuclease III-Assisted Target Recycling Amplification,
Analytical Chemistry, 2012, 84, 10845-10851.
38.Yan Zhang, Juan Hu, Chun-yang Zhang*, Sensitive Detection of Transcription Factors by Isothermal Exponential Amplification-Based Colorimetric Assay,
Analytical Chemistry, 2012, 84, 9544-9549.
39.Yi Long, Lingfei Zhang, Yan Zhang, Chun-yang Zhang*, Single QuantumDot-Based Nanosensor for Renin Assay,Analytical Chemistry, 2012, 84, 8846-8852.
40.Guolei Wang, Chun-yang Zhang*, Sensitive Detection of MicroRNAswith Hairpin Probe-Based Circular Exponential Amplification Assay, Analytical Chemisty, 2012, 84,7037-7042.
41.Anping Cao, Chun-yang Zhang*, Sensitive and Label-free DNAMethylation Detection by Ligation-Mediated Hyperbranched Rolling CircleAmplification,
Analytical Chemistry,2012, 84, 6199–6205.
42.Ying Li, Chun-yang Zhang*, Analysis of miRNA-Induced Silencing Complex-Involved miRNA-Target Recognition by Single-molecule Fluorescence Resonance
Energy Transfer, Analytical Chemistry, 2012, 84, 5097–5102.
43.Yong Yang, Chun-yang Zhang*, Sensitive Detection of IntracellularSumoylation via SNAP Tag-Mediated Translation and RNA Polymerase-
BasedAmplification, AnalyticalChemistry, 2012, 84, 1229–1234.
44.Zhen-zhu Zhang, Chun-yang Zhang*, Highly Sensitive Detection of Proteinwith Aptamer-Based Target-Triggering Two-Stage Amplification,
Analytical Chemistry, 2012, 84, 1623–1629.
45.Yan Zhang, Chun-yang Zhang*, Sensitive Detection of microRNA withIsothermal Amplification and a Single-Quantum-Dot-Based Nanosensor,
Analytical Chemistry, 2012, 84, 224–231.
46.Juan Hu, Chun-yang Zhang*, Single base extension reaction-based surfaceenhanced Raman spectroscopy for DNA methylation assay, Biosensors and
Bioelectronics, 2012, 31, 451-457.
47.Kun Yang, Chun-yang Zhang*, Simple Detection of Nucleic Acids with aSingle-walled Carbon-nanotube-based Electrochemical Biosensor, Biosensors and
Bioelectronics, 2011,28, 257-262.
48.Qiangxin Wang, Chun-yang Zhang*, Oriented Synthesis of One-dimensionalPolypyrrole Molecule Chains in a metal-organic framework, Macromolecular Rapid Communications, 2011, 32, 1610-1614.
49.Fangming Zhan, Chun-yang Zhang*, Bifunctional nanoparticles withsuperparamagnetic and luminescence properties, Journal of Material Chemistry,2011, 21，4765-4767.
50.Chun-yang Zhang*, Juan Hu, Single quantum dot-based nanosensor formultiple DNA detection. Analytical Chemistry, 2010, 82, 1921-7.
51.Juan Hu, Chun-yang Zhang*,Sensitive Detection of Nucleic Acids with Rolling Circle Amplification andSurface-Enhanced Raman Scattering Spectroscopy,
Analytical Chemistry,2010, 82, 8991–8997.
52.Kun Yang, Chun-yang Zhang*,Improved Sensitivity for the Electrochemical Biosensor with an Adjunct Probe, Analytical Chemistry, 2010, 82, 9500-9505.
53.Chun-yang Zhang, Lawrence W.Johnson, Single quantum-dot-based aptameric nanosensor for cocaine, Analytical Chemistry, 2009, 81, 3051-3055.
54.Chun-yang Zhang, Lawrence W. Johnson, Simple and AccurateQuantification of Quantum Dots via Single-particle Counting, Journal of the American Chemical Society,2008, 130, 3750-3751.
55.Chun-yang Zhang, Lawrence W. Johnson, Microfluidic control offluorescence resonance energy transfer: breaking the FRET limit, Angewandte Chemie
International Edition, 2007, 46, 3482-3485.
56.Chun-yang Zhang, Lawrence W. Johnson, Quantifying RNA-peptideinteraction by single-quantum-dot-based nanosensor: an approach for drugscreening,
Analytical Chemistry, 2007, 79, 7775-7781.
57.Chun-yang Zhang, Lawrence W. Johnson, Quantum-dot-based Nanosensor forRRE IIB RNA-Rev Peptide Interaction Assay, Journal of the American
Chemical Society, 2006, 128,5324-5325.
58.Chun-yang Zhang, Lawrence W. Johnson, Quantum-dot-based FluorescenceResonance Energy Transfer with Improved FRET Efficiency in Capillary Flows,
Analytical Chemistry, 2006, 78, 5532-5537.
59.Amit Agrawal,Chun-yang Zhang, Tyler Byassee, Ralph A. Tripp,Shuming Nie, Counting Single Native Biomolecules and Intact Viruses withColor-Coded
Nanoparticles, Analytical Chemistry, 2006, 78, 1061-1070.
60.Tza-Huei Wang, Yahui Peng, Chun-yang Zhang, Pak Kin Wong, Chih-Ming Ho,Single-molecule tracing on a fluidic microchip for quantitative detection
oflow-abundance nucleic acids,Journal of the American Chemical Society, 2005, 127, 5354-5359.
61.Chun-yangZhang, HsinChin Yeh, Marcos T. Kuroki, Tzahuei Wang, Single-quantum-dot-based DNA nonosensor,Nature Materials, 2005, 4, 826-831

研究课题






















荣誉称号