报告题目:Structure, Mechanism and Engineering of Several Key Enzymes in Biosynthesis and Biocatalysis.

　　报 告 人:周佳海 研究员

　　工作单位:中国科学院上海有机化学研究所

　　报告时间:2017年1月6日(星期五)9:00

　　报告地点:行政楼205会议室

　　报告人简介:

　　PROFESSIONAL EXPERIENCE

　　2006-Current Professor, State Key Laboratory of Bio-organic Chemistry and Natural Products,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai, China

　　2000-2001 　　Assistant Professor, State Key Laboratory of Bio-organic Chemistry and Natural Products,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai, China

　　1993-1995 Research Assistant, Nanjing Chemical Plant, Nanjing, Jiangsu, China

　　EDUCATION　　

　　1989-1993　 B.Sc, Analytical Chemistry, Nanjing University, China - Chemistry

　　1995-2000Ph.D., Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, China

　　2001-2006Postdoctoral Fellow, University of Michigan, Ann Arbor, USA

　　RESEARCH INTEREST

　　The research in Zhou laboratory is mainly focused on the structural mechanism and protein engineering of key enzymes in biocatalysis and biosynthesis. Our approaches include a variety of biochemical and biophysical methods, particularly the high-resolution x-ray crystallography and molecular dynamics.

　　RECENT PUBLICATIONS

　　1. Zhang J., Liu N., Cacho R.A., Gong Z., Liu Z., Qin W., Tang C., Tang Y.#, Zhou J.# (2016) Structural basis of nonribosomal peptide macrocyclization in fungi. Nature Chemical Biology, 12: 1001-1003.

　　2. Chen W.*, Li Y.*, Li J., Wu L., Li Y., Wang R., Deng Z.#, Zhou J.# (2016) An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis. Protein Cell, 7: 673-683.

　　3. Zhu H., Xu G., Zhang K., Kong X., Han R., Zhou J.#, Ni Y.# (2016) Crystal structure of tyrosine decarboxylase and key residues in conformational swing and substrate binding. Scientific Reports, 6:27779.

　　4. Zhou M.*, Xie L.*, Yang Z.*, Zhou J.#, Xie J.# (2016) Lysine succinylation ofMycobacterium tuberculosisisocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics. JournalofBiomolecular Structure & Dynamics, 19:1-12.

　　5. Sun Z., Lonsdale R.,Ilie A., Li G.,Zhou J., Reetz M.T. # (2016) Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis, 6:1598-1605.

　　6. Sun Z., Lonsdale R.,Wu L., Li G.,Li A.,Wang J.,Zhou J.#, Reetz M.T.# (2016) Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase. ACS Catalysis, 6:1590-1597.