报告题目：Genome Engineering: from biological parts to synthetic genome

　　报 告 人：戴俊彪 研究员

　　工作单位：清华大学生命科学学院

　　报告时间： 2015年10月29日（星期四）下午15:00-16:00

　　报告地点：行政办公楼205会议室

　　报告人简介：

　　戴俊彪研究员，1997年在南京大学获得学士学位，2000年和2006年分别在清华大学和Iowa State University获得硕士和博士学位。曾在Johns Hopkins University School of Medicine 从事博士后研究，2011年至今任清华大学生命科学学院研究员。

　　主要研究领域：

　　以酿酒酵母为模式生物，1）染色质生物学和表观遗传学：主要研究组蛋白新型修饰的鉴定和功能分析、组蛋白的系统性突变以及组蛋白—基因相互作用网络；2）合成生物学：主要研究合成基因组学、合成生物学相关技术的研发及其在环境、能源等领域的应用。

　　代表论著：

　　1.Chao Wu, Wei Xiong, Junbiao Dai* and Qingyu Wu*, Genome-based metabolic mapping and 13C flux analysis reveal systematic properties of an oleaginous microalga Chlorella protothecoides, Plant Physiol., 2015 167(2): 586-99. (*Co-corresponding author)

　　2.Li Zhao, Junbiao Dai* and Qingyu Wu*, Autophagy-like processes are involved in lipid droplet degradation in Auxenochlorella protothecoides during the heterotrophy-autotrophy transition, Front Plant Sci., 2014, 5: 400. (*Co-corresponding author)

　　3.Chunfang Gao, Yun Wang, Yue Shen, Dong Yan, Xi He, Junbiao Dai* and Qingyu Wu*, Oil accumulation mechanisms of the oleaginous microalga Chlorella protothecoides revealed through its genome, transcriptomes, and proteomes, BMC Genomics, 2014, 15: 582. (*Co-corresponding author)

　　4.Hanshuo Zhang, Juan Li, Sha Hou, Gancheng Wang, Mingjun Jiang, Changhong Sun, Xiongbing Hu, Fengfeng Zhuang, Zhifei Dai, Junbiao Dai* and Jianzhong Jeff Xi*, Engineered TAL Effector modulators for the large-scale gain-of-function screening, Nucleic Acids Res., 2014, 42(14): e114 (*Co-corresponding author)

　　5.Zhongyu Xie*, Junbiao Dai*, Lunzhi Dai, Minjia Tan*, Zhongyi Cheng, Yeming Wu, Jef D. Boeke, and Yingming Zhao, Lysine succinylation and lysine malonylation in histone, Mol Cell Proteomics, 2012, 11(5):100-7. (*equal contribution)

　　6.Jessica S. Dymond, Sarah M. Richardson, Candice E. Coombes, Timothy Babatz, Hélo?se Müller, Narayana Annaluru, William J. Blake, Joy Wu Schwerzmann, Junbiao Dai, Derek L. Lindstrom, Annabel C. Boeke, Daniel Gottschling, Srinivasan Chandrasegaran, Joel S. Bader, Jef D. Boeke, Fully synthetic chromosome arms function in yeast and generates phenotypic diversity, Nature, 2011, 477(7365): 471-6

　　7.Junbiao Dai, Edel M. Hyland, Anne Norris and Jef D. Boeke, Yin and yang of histone H2B’s role in silencing and longevity: a tale of two arginines, Genetics, 2010, 186(3): 813-828

　　8.Junbiao Dai*, Edel M. Hyland*, Daniel S. Yuan, Hailiang Huang, Joel S. Bader and Jef D. Boeke, Probing Nucleosome Function: A Highly Versatile Library of Synthetic Histone H3 and H4 Mutants, Cell, 2008, 134: 1066-1078 (Featured cover story *equal contribution)

　　9.Junbiao Dai*, Weiwu Xie*, Troy Brady, Jiquan Gao and Daniel F. Voytas, Phosphorylation regulates Ty5 integration specificity in Saccharomyces cerevisia, Mol Cell, 2007, 27(2): 289-299

　　(Featured in minireview: Mol. Cell 27:180-181. “Stress management: how cells take control of their transposons” Hirotaka E. and Levin H.L.)

　　10.Yunxia Zhu, Junbiao Dai, Peter G. Fuerst and Daniel F. Voytas, Controlling integration specificity of a yeast retrovirus-like element, PNAS, 2003, 100 (10): 5890-5895