姓名：刘雅
学历/职称/职务：博士/副教授/硕士生导师
邮箱：yaliu @ouc.edu.cn
地址：山东省青岛市鱼山路5号中国海洋大学科学馆210
科研领域：生物医用材料、纳米技术、药物递送、肿瘤治疗、组织工程、过度免疫治疗
学习工作简历：
2015年12月至今：中国海洋大学海洋生命学院副教授
2014年4月—2015年11月：中国海洋大学海洋生命学院讲师
2012年8月—2014年1月：国家纳米科学中心联合培养
2008年9月—2013年6月：中国海洋大学海洋生命学院海洋生物学专业博士
2004年9月—2008年6月：中国海洋大学海洋生命学院生物技术专业学士
科研领域：
主持国家自然科学基金、中国博士后基金特别资助、中国博士后科学面上基金、青岛市自主创新应用专项、青年教师专项基金等；获得山东省自然科学学术创新奖、山东省优秀博士学位论文、山东省研究生优秀科技创新成果奖、中国海洋大学第十四届优秀博士学位论文一等奖等多项学术奖励。
代表性成果
一．发表论文：
1. Ya Liu, Di Zhang , Zeng-Ying Qiao , Guo-Bin Qi , Xing-Jie Liang , Xi-Guang Chen*, Hao Wang*. A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy. Advanced Materials27(2015) 5034–5042(IF: 27.398)
2. Ya Liu, Li-Li Li, Guo-Bin Qi, Yun-Shan Fan, Xi-Guang Chen*,Hao Wang*. Dynamic Disordering of Co-Assemblied Liposomal Cocktails: Spatio-Temporal Controlled Release of Cargoes to Circumvent Drug Resistance.Biomaterials 35 (2014) 3406-3415. (IF: 10.317)
3. Ya Liu, Fu-Ping Gao, Di Zhang, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Molecular Structural Transformation Regulated Dynamic Disordering of Supramolecular Vesicles as pH-Responsive Drug Release Systems. Journal of Controlled Release 173 (2014) 140–147. (IF: 7.727)
4. Ya Liu, Xiguang Chen*, Hao Wang, Nanoplatform containing MMPs-sensitive peptide-PEG conjugate and tissue-penetrating moiety for enhanced cancer therapy. Journal of Controlled ReleaseDOI: 10.1016/j.jconrel.2017.03.324. (IF: 7.727)
5. Ya Liu*Pei-Pei Yang, Zeng-Ying Qiao, Hao Wang and Xi-Guang Chen*. Tumor Microenvironmental pH and Enzyme Dual Responsive Polymer-Liposomes for Synergistic Treatment of Cancer Immuno-Chemotherapy.Biomacromolecules 2019, 20, 882?892. (IF: 6.092)
6. Ya Liu*, Fang-Qin Wang, Zeana Shah, Xiao-Jie Cheng, Ming Kong, Chao Feng, Xi-Guang Chen*. Nano-polyplex based on oleoyl-carboxymethy-chitosan (OCMCS) andhyaluronic acid for oral gene vaccine delivery. Colloids and Surfaces B: Biointerfaces145 (2016) 492–501.(IF: 4.389)
7. Ya Liu, Ming Kong, Xiao Jie Cheng, Qian Qian Wang, Li Ming Jiang, Xi Guang Chen*. Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery. Carbohydrate Polymers 94 (2013) 309-316.(IF: 7.182)
8. Ya Liu, Ming Kong, Kui Kun Yang, Yang Li, Jing Su, Xiao Jie Cheng, Hyun Jin Park*, Xi Guang Chen*. Biocompatibility, cellular uptake and biodistribution of the polymeric amphiphilic nanoparticles as oral drug carriers. Colloids and Surfaces B: Biointerfaces103 (2013) 345-353.(IF: 4.389)
9. Ya Liu, Hui Di Zang, Ming Kong, Fang Kui Ma, Qi Feng Dang, Xiao Jie Cheng*, Qiu Xia Ji, Xi Guang Chen*. In vitroevaluation of mucoadhesion and permeation enhancement of polymeric amphiphilic nanoparticles. Carbohydrate Polymers 89 (2012) 453– 460.(IF: 7.182)
10. Ya Liu, Xiao Jie Cheng, Qi Feng Dang, Fang Kui Ma, Xi Guang Chen*, Hyun Jin Park, Bum Keun Kim. Preparation and evaluation of Oleoyl-carboxymethy-chitosan (OCMCS) nanoparticles as oral protein carriers. Journal of Material Science: Material in Medicine.23(2012) 375–384.(IF: 2.489)
11. Mengjie Sun, Ting Wang, Jianhui Pang, Xiguang Chen, Ya Liu*. Hydroxybutyl Chitosan Centered Biocomposites for Potential Curative Applications: A Critical Review.Biomacromolecules. 2020, 21,1351-1367.(IF: 6.092)
12. Xuqian Lang, Ting Wang, Mengjie Sun, Xiguang Chen, Ya Liu*. Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review. International Journal of Biological Macromolecules154 (2020) 433-445. (IF: 5.162)

13. Congshan Yuan^#, Ya Liu^#, Ting Wang, Mengjie Sun, and Xiguang Chen*. Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy. ACS Biomaterials Science & Engineering.doi.org/10.1021/acsbiomaterials.0c00804. (IF: 4.152)

14. Zhenwei Deng, Ting Wang, Xiguang Chen, Ya Liu*. Applications of chitosan?based biomaterials: a focus on dependent antimicrobial properties. Marine Life Science & Technology. https://doi.org/10.1007/s42995-020-00044-0.
15.Mengjie Sun, Xiaoping Yu, Ting Wang, Shichao Bi, Ya Liu*, Xiguang Chen*. Nasal adaptive chitosan-based nano-vehicles for anti-allergic drug delivery. International Journal of Biological Macromolecules135 (2019) 1182–1192 (IF: 5.162)
16. Ting Wang, FangqinWang, Mengjie Sun, Meiping Tian, Yuzhi Mu, Xiguang Chen, Ya Liu*. Gastric environment-stable oral nanocarriers for in situ colorectal cancer therapy. International Journal of Biological Macromolecules139 (2019) 1035–1045(IF: 5.162)
17. Mei-Ping Tian, Rui-Xi Song, Ting Wang, Meng-Jie Sun, Ya Liu*, Xi-Guang Chen*. Inducing sustained release and improving oral bioavailability of curcumin via chitosan derivatives-coated liposomes. International Journal of Biological Macromolecules. 120 (2018) 702–710.(IF: 5.162)
18. Zixian Bao, Changqing Jiang, Zhiguo Wang, Qiuxia Ji, Guohui Sun, Shichao Bia, Ya Liu*, Xiguang Chen*. The influence of solvent formulations on thermosensitive hydroxybutyl chitosan hydrogel as a potential delivery matrix for cell therapy. Carbohydrate Polymers170 (2017) 80–88.(IF: 7.182)
19. Juan Wang, Ming Kong, Zhenjin Zhou, Dong Yan, Xiaoping Yu, Xiaojie Cheng, Chao Feng, Ya Liu*, Xiguang Chen*. Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery. Carbohydrate Polymers157 (2017) 596–602.(IF: 7.182)
20. Guixue Xia, Ya Liu*, Meiping Tian, Ping Gao, Zixian Bao, Xiaoyu Bai, Xiaoping Yu, Xuqian Lang, Shihao Hu and Xiguang Chen*. Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds.Journal of Materials Chemistry B 5 (2017)3172—3185.(IF: 5.344)
21. Zixian Bao, Ping Gao, Guixue Xia, Zhiguo Wang, Ming Kong, Chao Feng, Xiaojie Cheng*, Ya Liu* and Xiguang Chen*. A thermosensitive hydroxybutyl chitosan hydrogel as a potential co-delivery matrix for drugs on keloid inhibition. Journal of Materials Chemistry B 4(2016) 3936—3944.(IF: 5.344)
22. Ping Gao, Guixue Xia, Zixian Bao, Chao Feng, Xiaojie Cheng, Ming Kong, Ya Liu*, Xiguang Chen*. Chitosan based nanoparticles as protein carriers for efficient oral antigen delivery. International Journal of Biological Macromolecules 91 (2016) 716–723.(IF: 5.162)
23. Fangqin Wang, Guixue Xia, Xuqian Lang, Xuanxuan Wang, Zixian Bao, Zeenat Shah, Xiaojie Cheng, Ming Kong, Chao Feng, Ya Liu*, Xiguang Chen*. Influence of the graft density of hydrophobic groups on thermo-responsive nanoparticles for anti-cancer drugs delivery. Colloids and Surfaces B: Biointerfaces148 (2016) 147–156.(IF: 4.389)
二．专利
1.刘雅，张安迪，陈西广. 一种兼具自愈性和黏附性的复合水凝胶的制备方法，国家发明专利、申请号：5.7
2.刘雅，孙梦杰，陈西广, 程晓杰, 孔明, 冯超. 一种兼具抑制组胺释放与组胺受体拮抗功能的纳米颗粒的制备方法, 国家发明专利、申请号7.5
3.刘雅, 田美平, 陈西广, 程晓杰, 孔明, 冯超. 一种具有黏附性和抑菌性的温敏性水凝胶的制备方法, 国家发明专利、申请号5.X
4.刘雅, 夏桂雪, 陈西广, 程晓杰, 孔明, 冯超.一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法, 国家发明专利、申请号7.X
5.刘雅, 王方勤,陈西广,程晓杰, 孔明,冯超.一种pH?温度双敏感性壳聚糖纳米颗粒的制备方法, 国家发明专利、申请号8.4
6.刘雅，陈西广，程晓杰，孔明，冯超. 一种壳寡糖透明质酸复合纳米微粒的制备方法,国家发明专利、专利号ZL20**0.2