王岩，教授，博士生导师，中国海洋大学青年英才第一层次
联系方式：wangy12@ouc.edu.cn中国海洋大学鱼山校区化学馆304室



教育及研究经历：
2019.7至今 中国海洋大学海洋生命学院，“青年英才第一层次”，
教授，博士生导师
2014.5-2019.7 中国海洋大学海洋生命学院，“青年英才第三层次”，副教授, 硕士生导师
2013.2-2014.5 美国内布拉斯加-林肯大学化学系博士后
2010.10-2012.10 美国内布拉斯加-林肯大学化学系访问****
2007.9-2012.12 山东大学微生物技术国家重点实验室，博士
2003.9 -2007.6 山东师范大学生命科学学院，本科

获得荣誉：
1. 入选2016年度中国科协“青年人才托举工程”人才支持计划；
2. 2014年山东省优秀博士论文；
3. 2015年国际合成生物学大赛世界银奖；
4. 美国内布拉斯加大学生化会议最佳海报奖；

研究方向：
1. 海洋微生物群体感应与感应淬灭机制；
2.抑制病害细菌耐药性的新策略研究；
3. 海洋微生物蛋白资源发掘及在抑制病害菌方面的应用技术；

主要承担课题：
1.国家自然科学基金面上项目：“吲哚抑制细菌耐药性的新型机制研究”（**，2019.01-2022.12），项目负责人
2. 国家自然科学基金面上项目：“新型密度感应淬灭酶MomL的作用机制及其在植物细菌性病害防治中的应用”（**，2016.01-2019.12），项目负责人
3. 国家自然科学基金青年项目：“深海新菌深渊藤黄单胞菌新型α-淀粉酶的温度适应性机制研究”（**，2016.01-2018.12），项目负责人
4. 中国科协“青年人才托举工程”支持计划，2016-2018，项目负责人
5. 中国海洋大学优青培育计划，2018-2021，项目负责人
6.鳌山科技创新计划，青岛海洋科学与技术国家实验室，海洋微型生物多样性格
局与演化机制，2018.01-2020.12，参加
7. 山东省自然科学基金：“海洋耐油具柄菌密度感应淬灭酶的作用机制研究及应用”（2014ZRE29014，2014.12-2017.12），项目负责人
8. 留学回国基金：项目负责人
9. 中国博士后基金面上项目一等资助：“耐油具柄菌信号分子降解酶MalM与铁硫簇suf相关性分析”（2014.8-2016.1），项目负责人
10. 中国博士后基金特别资助：项目负责人
11. 中国海洋大学英才计划科研启动基金：（2014.6-2016.5），项目负责人

代表性论文：

Yan Wang*＆, Tian Tian＆, Jingjing Zhang＆, Xin Jin＆, Huan Yue,Xiao-Hua Zhang, Liangcheng Du, Fan Bai*, 2019,Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer. mBio,2019,Volume 10 Issue 3 e00676-19 (TOP期刊)
Tao Feng, Yong Han, Bingqing Li, Zhiqiang Li, Yameng Yu, Qingyang Sun, Xiaoyu Li, Liangcheng Du, Xiaohua Zhang, Yan Wang*. Interspecies and Intraspecies Signals Synergistically Regulate Lysobacter enzymogenesTwitching Motility.Applied and Environmental Microbiology, 2019. doi:10.1128/AEM.01742-19 (TOP期刊)
Yan Wang*, Tao Feng, Hui Li, Yameng Yu, Yong Han, Jingjing Zhang, Xiaoyu Li, Yaoyao Li, Xiao-Hua Zhang* A novel heterologous expression strategy of quorum quenching enzyme MomL in Lysobacter enzymogenes to inhibit pathogenicity of Pectobacterium. Appl Microbiol Biotechnol, 2019. https://doi.org/10.1007/s00253-019-10166-w (TOP期刊)
Jiayi Wang, Jing Lin, Yunhui Zhang, Jingjing Zhang, Tao Feng, Hui Li, Xianghong Wang, Qingyang Sun, Xiaohua Zhang and Yan Wang* (通讯作者) Activity Improvement and Vital Amino Acid Identi?cation on the Marine-Derived Quorum Quenching Enzyme MomL by Protein Engineering, Marine Drugs2019, 17, 300; doi:10.3390/md**
Jingjing Zhang, Jiayi Wang, Tao Feng , Rui Du , Xiaorong Tian , Yan Wang * (通讯作者) and Xiao-Hua Zhang, 2019 Heterologous Expression of the Marine-Derived Quorum Quenching Enzyme MomL Can Expand the Antibacterial Spectrum of Bacillus brevis. Marine Drugs2019, 17, 128; doi:10.3390/md**
Ying Su, Kaihao Tang, Jiwen Liu, Yan Wang, Yanfen Zheng, Xiao-Hua Zhang, 2019. Quorum sensing system of Ruegeria mobilisRm01 controls lipase and biofilm formation. Frontiers in Microbiology, https://doi.org/10.3389/fmicb.2018.03304
Yong Han^＆, Wang Yan^＆(并列一作), Yameng Yu, Haotong Chen, Yuemao Shen, Liangcheng Du,2017.Indole-induced Reversion of Intrinsic Multi-antibiotic Resistance in Lysobacter enzymogenes. Applied and Environmental Microbiology.17;83(17). pii: e00995-17 (TOP期刊)
Wang Yan, Hui Li, Xinxin Cui& Xiao-Hua Zhang*,2017.A novel stress response mechanism, triggered by indole,involved in quorum quenching enzyme MomL and iron-sulfur cluster in Muricauda olearia Th120. Scientific Reports26;7(1):4252 ( doi:10.1038/s41598-017-04606-8)
Zhuo Li^＆, Wang Yan^＆(并列一作), Zhang Zheng, Li Jian, Zhang Xiao-Hua, Li Yue-zhong, 2017. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groELand single groESgenes for synergistic functions of GroELs and GroES. Frontiers in Microbiology. (doi: 10.3389/fmicb.2017.00733)
Wang Yan, Qinghao Song, Xiao-Hua Zhang*. 2016. Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects. Marine Drugs, 14(10), 171; doi:10.3390/md**.
Qinghao Song, Wang Yan*(通讯作者), Chong Yin, Xiao-Hua Zhang*. 2016. LaaA, a novel cold-adaptive alkalophilic alpha-amylase from deep-sea bacterium Luteimonas abyssiXH031. Enzyme and Microbial Technology, DOI:10.1016/j.enzmictec.2016.05.003 (corresponding author)
Li Zhang^＆, Wang Yan^＆(并列一作), Jing Liang, Qinghao Song, Xiao-Hua Zhang*. 2016.Degradation properties of various macromolecules of cultivable psychrophilic bacteria from the deep sea water of the South Pacific Gyre. Extremophiles, DOI: 10.1007/s00792-016-0856-4 (co-first author)
Wang Yan, Xiaojing Chen, and Yue-zhong Li*. 2016. Duplicated groEL genes in Myxococcus xanthus DK1622. Stress and Enviromental Regulation of Gene Expression and Adaptation in Bacteria, chapter 14.5.
Han Y^＆, Wang Yan^＆(并列一作), Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen, Liangcheng Du. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl Microbiol Biotechnol, 99(2):801-11. (co-first author) (TOP期刊)
Wang Yan.^＆, X. Li^＆, W. Zhang, X. Zhou, and Y. Z. Li. 2014. The groEL2gene, but not groEL1, is required for biosynthesis of the secondary metabolite myxovirescin in Myxococcus xanthus DK1622. Microbiology160:488-495.
Wang Yan^＆, W. Y. Zhang^＆, Z. Zhang, J. Li, Z. F. Li, Z. G. Tan, T. T. Zhang, Z. H. Wu, H. Liu, and Y. Z. Li. 2013. Mechanisms Involved in the Functional Divergence of Duplicated GroEL Chaperonins in Myxococcus xanthus DK1622. PLoS Genetics9:e**. (TOP期刊)
Wang Yan,G. Qian, F. Liu, Y. Z. Li, Y. Shen, and L. Du. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenesfor yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synth Biol 2:670-678. (ACS Synthetic Biology launched on 2012, IF: 6.1)
Wang Yan^＆, Qian, GL.^＆, Li, YY., Wang, YS., Wang, YL., Wright Stephen, Li, YZ., Shen, YM., Liu, FQ., Du, LC. 2013. Biosynthetic mechanism for sunscreen of the biocontrol agent lysobacter enzymogenes. PLoS One8(6): e66633.doi:10.1371/journal.pone.**. (Cited by Cell)
Zhang, W., Y. Li, G. Qian,Wang Yan, H. Chen, Y. Z. Li, F. Liu, Y. Shen, and L. Du. 2011. Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenesOH11. Antimicrob Agents Chemother 55:5581-5589.
Li, J.^＆,Wang Yan^＆(并列一作), C. Y. Zhang, W. Y. Zhang, D. M. Jiang, Z. H. Wu, H. Liu, and Y. Z. Li. 2010. Myxococcus xanthus viability depends on groELsupplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development. Journal of Bacteriology192:1875-1881. (co-first author)
Li Zhuo, Wang Yan, Zheng Zhang, and Yue-Zhong Li. Dynamic Interplay oftheMyxobacterial Chaperonins. Prokaryotic Chaperonins: multiple copies and multitude functions2017, Springer

专利 (第一发明人)：
1.一种新型α-淀粉酶及其应用； .4, 已授权
2.一种异源表达群体感应淬灭酶的方法；1.3
3.一种用于农作物病害防治的重组菌株；2.8
4.一种用于病害防治的高活力蛋白的构建方法与应用；2.8， 已授权
5.一种基于抑制细菌毒力释放的降低抗生素用量的方法与应用；6.1
6.吲哚在制备抑制黄单胞菌科细菌抗生素耐药性药物中的应用；7.8