姓名：高珊

学历/职称/职务：博士，教授

联系方式：

邮箱：shangao@ouc.edu.cn

电话：**

地址：中国海洋大学鱼山校区达尔文馆211室

网址：http://www2.ouc.edu.cn/akfs/Sub_Index.asp?ID=1&tab=memo_display&MemoName=gaoshan
科研方向：

以嗜热四膜虫为模式生物，从事表观遗传学的研究，主要兴趣包括：1）DNA复制的表观遗传调控机制； 2）表观遗传信息对四膜虫大小核分化及基因表达的调控机理。
教育经历：

2005/09 – 2011/06 中国海洋大学，理学博士

2006/10 – 2007/03 德国基尔大学，中德交换博士生

2009/01 – 2010/12 美国密歇根大学，“国家建设高水平大学公派研究生项目” 联合培养博士生

2001/09 – 2005/06 中国海洋大学，理学学士
工作经历：

2014/03 –至今，中国海洋大学，海洋生物多样性与进化研究所，教授

2011/07 – 2014/01，美国密歇根大学，病理学系, 博士后

主持或参加科研项目及人才基金项目情况：

1. 国家自然科学基金面上项目，**、以纤毛虫原生动物-嗜热四膜虫为模式：DNA复制延伸相关的表观遗传学研究、2015/01-2016/12、30万元、在研、主持。

2. 山东省自然科学基金青年基金项目，ZR2014CQ011、表观遗传信息对复制延伸过程及脆性位点表达的调控研究、2014/08-2017/08、12万元、在研、主持。

3. 中国海洋大学“英才计划”特别资助项目，筛选影响DNA复制的表观遗传因子、2014/03-2017/03、60万元、在研、主持。
近5年代表性文章：

1. Shan Gao, Ling Lu, Yan Bai, Weibo Song, and Cunming Duan. Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family. FASEB Journal, 2014, 28, 1880-1890 (IF=6.2).

2. Feng Gao, Shan Gao (通讯作者), Pu Wang, Laura Katz, and Weibo Song. Phylogenetic analyses of cyclidiids (Protista, Ciliophora, Scuticociliatia) based on multiple genes suggest their close relationship with thigmotrichids. Molecular Phylogenetics and Evolution, 2014, 75, 219-226 (IF=4.2).

3. Shan Gao, Jie Xiong, Chunchao Zhang, Brian R. Berquist, Rendong Yang, Meng Zhao, Anthony J. Molascon, Shaina Y. Kwiatkowski, Dongxia Yuan, Zhaohui Qin, Jianfen Wen, Geoffrey M. Kapler, Philip C. Andrews, Wei Miao, and Yifan Liu. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes & Development, 2013, 27, 1662-1679 (IF=12.6).

4. Yuan Xu, Shan Gao (通讯作者), Xiaozhong Hu, Khaled AS Al-Rasheid, and Weibo Song. Phylogeny and systematic revision of the karyorelictid genus Remanella (Ciliophora, Karyorelictea) with descriptions of two new species. European Journal of Protistology, 2013, 49, 438-452 (IF=2.3).

5. Jiamei Li, Weiwei Liu, and Shan Gao (通讯作者), Alan Warren, Weibo Song. Multigene-based analyses of the phylogenetic evolution of oligotrich ciliates, with consideration of the Internal Transcribed Spacer 2 secondary structure of three systematically ambiguous genera. Eukaryotic Cell, 2013, 12, 430-437 (IF=3.7).

6. Shan Gao and Yifan Liu. Intercepting noncoding messages between germline and soma. Genes & Development, 2012, 26, 1774-1779 (IF=12.6).

7. Shan Gao, Jie Huang, Jiamei Li, and and Weibo Song. Molecular phylogeny of the cyrtophorid ciliates (Protozoa, Ciliophora, Phyllopharyngea). Plos One, 2012, 7 (3), e33198 (IF=4.1).

8. Shan Gao, Michaela C. Strüder-Kypke, Khaled A. S. Al-Rasheid, Xiaofeng Lin, and Weibo Song. Molecular phylogeny of three ambiguous ciliate genera: Kentrophoros, Trachelolophos and Trachelotractus (Alveolata, Ciliophora). Zoologica Scripta, 2010, 39, 305-313 (IF=3.1).

9. Chunchao Zhang, Shan Gao, Yifan Liu, and Philip C. Andrews. Quantitative Proteomics Reveals Histone Modifications in Crosstalk with H3 Lysine 27 Methylation. Molecular & Cellular Proteomics, 2014, 13, 749-759 (IF=7.3).

10. Chunchao Zhang, Anthony J. Molascon, Shan Gao, Yifan Liu, and Philip C. Andrews. Quantitative proteomics reveals that the specific methyltransferases Txr1p and Ezl2p differentially affect the mono-, di-and tri-methylation states of histone H3 lysine 27. Molecular & Cellular Proteomics, 2013, 12, 1678–1688 (IF=7.3).

11. Xiangrui Chen, Shan Gao, Weiwei Liu, Weibo Song, Khaled AS Al-Rasheid, and Alan Warren. Taxonomic descriptions of three marine colepid ciliates, Nolandia sinica spec. nov., Apocoleps caoi spec. nov. and Tiarina fusa (Claparède & Lachmann, 1858) Bergh, 1881 (Ciliophora, Prorodontida). International journal of systematic and evolutionary microbiology, 2012, 62, 735-744 (IF=2.8).

12. Xiangrui Chen, Shan Gao, Weibo Song, Khaled A. S. Al-Rasheid, Alan Warren, Jun Gong, and Xiaofeng Lin. Parabirojimia multinucleata spec. nov. and Anteholosticha scutellum (Cohn, 1866) Berger, 2003, two marine ciliates (Ciliophora, Hypotrichida) from tropical waters in southern China, with note on their SSU rRNA gene sequences. International Journal of Systematic and Evolutionary Microbiology, 2010, 60, 234-243 (IF=2.8).

13. Cunming Duan, Hongxia Ren, and Shan Gao. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation. General and Comparative Endocrinology, 2010, 167, 344-351 (IF=2.7).