姓名：杨艳

学历/职称/职务：博士，讲师

联系方式：**

邮箱：yany@ouc.edu.cn 电话：**

地址：青岛市鱼山路5号，中国海洋大学海洋生命学院 工作照：

学习工作简历：

受教育经历：

2000/09– 2005/06，中国海洋大学，海洋生命学院，博士

1996/09– 2000/06，烟台大学，化学生物理工学院，学士

研究工作经历：

2005/09 –2009/02，中国海洋大学，海洋生命学院，讲师

2009/03– 2010/02，美国国立卫生研究院，癌症研究所，博士后

2010/03– 2011/06 ，中国海洋大学，海洋生命学院，讲师

2011/07– 2012/03，美国国立卫生研究院，癌症研究所，交流访问

2012/04–，中国海洋大学，海洋生命学院，讲师




科研领域描述：

（1）海洋生物酶类产生菌的筛选、发酵、酶的分离纯化，活性及作用机理研究

（2）壳聚糖基纳米材料在基因递送中的应用

（3）载基因壳聚糖纳米复合物在疾病的基因治疗中的应用研究

代表性成果：

[1]Liu J, Cai W, Liu W, Han B, Chang J, Yang Y. Modulation of liver L-glutamyl -L-cysteinylglycine homeostasis by N-acetyl-glucosamine-thiazolidine-4(R)-carboxylic acid in mice. Am J Med Sci.343(4): 310-5，2012.

[2]Yang Yan, Liu Ying, Yao Xiaohong, Huang Jian, Wang Jiming. Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through formyl peptide receptor 1. American Journal of Pathology, 179(3):1504-12，2011.

[3]Ying Liu, Yan Yang, Xiaohong Yao, Jian Huang, Wanghua Gong, Keqiang Chen1, Xiuwu Bian, Ji Ming Wang. Identification of Annexin 1 (Anx A1) as a necrotic glioblastoma cell-derived chemotactic agonist for the G protein- coupled receptor FPR (FPR1) Cytokine, 52(1–2):24–25，2011.

[4]张沛，韩宝芹，陈列欢，彭燕飞，刘万顺，杨艳，用酶法制备壳寡糖及其对机体免疫功能的调节作用。中国免疫学杂志，28（1）：8-13,2013.

[5]Chenghua Guo, Xuexi Tang, Xinwei Dong, Yan Yang. Studies on the expectorant, antitussive and antiasthmatic properties of asterosaponin extracted from Luidis quinaria. African Journal of Biotechnology. 2009;8(23): 6694-9996.

[6]Yang Yan, Liu Wanshun, Han Baoqin, Wang Changhong, Fu Chenwei, Liu Bing, Chen Liehuan. The antioxidative and immunostimulating properties of D-glucosamine. International Immunopharmacology, 2007;7:29-35.

[7]Chun L. Li, Yan Yang, Bao Q. Han, Wan S. Liu. Antioxidant activity of N-acetyl-glucosamine based thiazolidine derivative. High-tech Letters. 2007;13:15-21

[8]Yang Yan, Liu Wan-Shun, Han Bao-Qin, Sun Hai-Zhou. Antioxidative Properties of a newly synthesized 2-glucosamine-thiazolidine-4(R)- Carboxylic Acid (GlcNH2Cys) in mice. Nutrition Research, 2006;26: 369-377.

[9]Yang Yan, Liu Wanshun, Han Baoqin, Liu Bing, Fu Chenwei. Protective effects of chitosan oligosaccharide and its derivatives against carbon tetrachloride induced liver damage in mice. Hepatology Research, 2006;35:178-184.

[10]Jin Liming, Liu Wanshun, Han Baoqin, Yang Yan, Tian Wenjie, Fan Shengdi. Factors influencing the in vitro culture of osteoblasts. Chinese Jounal of Clinical Rehabilitation. 2006,20(9):190-192.

[11]Yang Yan, Liu Wanshun, Han Baoqin, Fu Chenwei, Sun Haizhou. Synthesis of two new thiazolidines and evaluation of their hepatoprotective effects. High-tech Letters, 2005;11 (1): 437-442

[12]Yang Yan, Liu Wanshun, Han Baoqin, Sun Mingkun, Zheng Qiusheng. Antioxidative Properties of 2-Substituted-Thiazolidine-4(R)-Carboxylic Acids. ACTA Biochimica et Biophysica Sinica. 2003 (35): 11

[13]金黎明，杨艳，刘万顺，韩宝芹，田文杰，范圣第。壳寡糖及其衍生物对CCl4诱导的小鼠肝损伤的保护作用。山东大学学报（理学版）2007；42(7):1-5

[14]付辰炜，刘万顺，韩宝芹，杨艳，刘冰。氨基葡萄糖对小鼠免疫功能的影响。营养学报，2007；29（1）：51-55

[15]刘吉，蔡文迪，杨艳，刘万顺，韩宝芹，常菁。噻唑烷酸提高肝组织GSH含量功能的研究。中国海洋大学学报







Curriculum Vitae

Name: Yan Yang

Title : PhD, Lecturer

Contact

Email：yany@ouc.edu.cn Tel：**

Address：Ocean University of China

5 Yushan Road, Qingdao,P.R.China Photo

Experiences:

Education:

2000/09– 2005/06，Ocean University of China，Department of Marine Life Sciences，PhD

1996/09– 2000/06，Yantai University，Department of Life Sciencse，Bachelor

Research:

2005/09 –2009/02，，Ocean University of China，Department of Marine Life Sciences，Lecturer

2009/03– 2010/02，National Cancer Institute, National Institutes of Health, US, Postdoc research

2010/03– 2011/06 ，Ocean University of China，Department of Marine Life Sciences，Lecturer

2011/07– 2012/03，National Cancer Institute, National Institutes of Health, US, Visiting

2012/04–，Ocean University of China，Department of Marine Life Sciences，Lecturer




Research Interests:

（1）Screening of marine enzyme producing microorganism, fermentation, enzyme purification, activity and mechanisms.

（2）Chitosan based nanoparticles as gene carriers

（3）Chitosan based nanoparticles loaded with SiRNA in gene therapy.

Achievements:

[1]Liu J, Cai W, Liu W, Han B, Chang J, Yang Y. Modulation of liver L-glutamyl -L-cysteinylglycine homeostasis by N-acetyl-glucosamine-thiazolidine-4(R)-carboxylic acid in mice. Am J Med Sci.343(4): 310-5，2012.

[2]Yang Yan, Liu Ying, Yao Xiaohong, Huang Jian, Wang Jiming. Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through formyl peptide receptor 1. American Journal of Pathology, 179(3):1504-12，2011.

[3]Ying Liu, Yan Yang, Xiaohong Yao, Jian Huang, Wanghua Gong, Keqiang Chen1, Xiuwu Bian, Ji Ming Wang. Identification of Annexin 1 (Anx A1) as a necrotic glioblastoma cell-derived chemotactic agonist for the G protein- coupled receptor FPR (FPR1) Cytokine, 52(1–2):24–25，2011.

[4]张沛，韩宝芹，陈列欢，彭燕飞，刘万顺，杨艳，用酶法制备壳寡糖及其对机体免疫功能的调节作用。中国免疫学杂志，28（1）：8-13,2013.

[5]Chenghua Guo, Xuexi Tang, Xinwei Dong, Yan Yang. Studies on the expectorant, antitussive and antiasthmatic properties of asterosaponin extracted from Luidis quinaria. African Journal of Biotechnology. 2009;8(23): 6694-9996.

[6]Yang Yan, Liu Wanshun, Han Baoqin, Wang Changhong, Fu Chenwei, Liu Bing, Chen Liehuan. The antioxidative and immunostimulating properties of D-glucosamine. International Immunopharmacology, 2007;7:29-35.

[7]Chun L. Li, Yan Yang, Bao Q. Han, Wan S. Liu. Antioxidant activity of N-acetyl-glucosamine based thiazolidine derivative. High-tech Letters. 2007;13:15-21

[8]Yang Yan, Liu Wan-Shun, Han Bao-Qin, Sun Hai-Zhou. Antioxidative Properties of a newly synthesized 2-glucosamine-thiazolidine-4(R)- Carboxylic Acid (GlcNH2Cys) in mice. Nutrition Research, 2006;26: 369-377.

[9]Yang Yan, Liu Wanshun, Han Baoqin, Liu Bing, Fu Chenwei. Protective effects of chitosan oligosaccharide and its derivatives against carbon tetrachloride induced liver damage in mice. Hepatology Research, 2006;35:178-184.

[10]Jin Liming, Liu Wanshun, Han Baoqin, Yang Yan, Tian Wenjie, Fan Shengdi. Factors influencing the in vitro culture of osteoblasts. Chinese Jounal of Clinical Rehabilitation. 2006,20(9):190-192.

[11]Yang Yan, Liu Wanshun, Han Baoqin, Fu Chenwei, Sun Haizhou. Synthesis of two new thiazolidines and evaluation of their hepatoprotective effects. High-tech Letters, 2005;11 (1): 437-442

[12]Yang Yan, Liu Wanshun, Han Baoqin, Sun Mingkun, Zheng Qiusheng. Antioxidative Properties of 2-Substituted-Thiazolidine-4(R)-Carboxylic Acids. ACTA Biochimica et Biophysica Sinica. 2003 (35): 11

[13]金黎明，杨艳，刘万顺，韩宝芹，田文杰，范圣第。壳寡糖及其衍生物对CCl4诱导的小鼠肝损伤的保护作用。山东大学学报（理学版）2007；42(7):1-5

[14]付辰炜，刘万顺，韩宝芹，杨艳，刘冰。氨基葡萄糖对小鼠免疫功能的影响。营养学报，2007；29（1）：51-55

[15]刘吉，蔡文迪，杨艳，刘万顺，韩宝芹，常菁。噻唑烷酸提高肝组织GSH含量功能的研究。中国海洋大学学报