姓名：刘振辉
学历/职称/职务：博士/教授/生物系副主任
联系方式：
邮箱：zhenhuiliu@ouc.edu.cn 电话: **
地址：青岛市鱼山路5号
学习工作简历：
2012-2013, 美国Utah State University访问学者，从事味觉与肥胖调控机理研究；
2007-2008，法国欧洲味觉研究中心博士后，德国汉堡大学分子神经研究所博士后，从事味觉的分子

机理研究；
2003-现在，中国海洋大学海洋生命学院讲师、副教授、教授，主要从事原索动物和鱼类的发育、免

疫与进化研究。2008年获教育部新世纪优秀人才；
2000-2003, 中国海洋大学海洋生物学专业，获博士学位；
1997-2000，中国海洋大学水产养殖专业，获硕士学位。
科研领域描述：
1) 脂味觉的分子机制与肥胖调控研究：主要以模式动物斑马鱼为研究对象，鉴定新的脂味觉受体，

并对脂类摄食与肥胖的调控进行研究，进而开发具有调节肥胖作用的潜在药物；
2) 分子进化研究：主要以处于无脊椎动物与脊椎动物进化节点的文昌鱼为研究对象，揭示嗅觉、内

分泌调控和免疫等系统进化的奥秘；
3）海洋生物功能基因开发：对具有潜在重要应用价值的海洋生物功能基因进行克隆并研究其功能。

代表性成果：
研究课题：
国家自然科学基金主任基金“脂肪酸受体CD36 在鱼类摄食脂类的味觉感知中的作用研究”

(**)，15.00万元，2014.1-2014.12;
海洋“863”重点项目“海洋模式生物文昌鱼免疫防御的关键基因研究” （2008AA092603），132万

元，2008-2012；
教育部新世纪优秀人才项目“鱼类卵黄脂磷蛋白免疫新功能的分子机理研究”，50万元，2009-2011

；
留学回国启动基金，3万元，2010-2012；
国家自然科学基金 “文昌鱼CD19类蛋白的鉴定及基因克隆与进化研究”（**），22万元，

2006.1-2008.12；
海洋“863” 子课题 “海洋重要动物免疫相关基因的研究与开发”（2005AA626012），109万元，

2005-2006;

奖励：
山东省自然科学奖一等奖一项（第二位），2007年；
教育部自然科学奖二等奖一项（第二位），2006年；
国家海洋局海洋创新成果一等奖一项（第五位），2004年；
山东省高等学校自然科学奖一等奖（第二位），2006年；
青岛市自然科学一等奖（第二位），2005年；
中国海洋大学优秀班主任和中国海洋大学“天泰”优秀教师奖，2006年。
山东省优秀硕士毕业论文指导奖，2012年。

代表论文：(*示通讯作者）共发表论文50余篇，其中第一作者或通讯作者19篇。
Liu, Zhenhui, Fenech, Claire, Cadiou, Herve, Grall, Sylvie, Tili, Esmerina, Laugerette,

Fabienne, Wiencis, Anna, Grosmaitre, Xavier, Montmayeur, Jean-Pierre*, Identification

of new binding partners of the chemosensory signaling protein G gamma 13 expressed in

taste and olfactory sensory cells, Frontiers in Cellular Neuroscience, 6, pp 1-21,

2012. IF=4.1710
Liu, Zhenhui*, Xu, Yanping, Wu, Ling, Zhang, Shicui, Evolution of Galanin Receptor

Genes: Insights from the Deuterostome Genomes, JOURNAL OF BIOMOLECULAR STRUCTURE &

DYNAMICS, 28(1), pp 97-106, 2010. IF=4.9860
Huang Q, Feng D, Liu K, Wang P, Xiao H, Wang Y, Zhang S, Liu Zhenhui*. A medium-chain

fatty acid receptor Gpr84 in zebrafish: Expression pattern and roles in immune

regulation. Dev Comp Immunol. 2014， 45(2): 252-258. IF=3.238
Zhang M, Yanping Xu, Linfang Li, Shulei Wei, Shicui Zhang and Liu Zhenhui*,

Identification, evolution and expression of a CD36 homolog in the basal chordate

amphioxus Branchiostoma japonicum,, Fish & Shellfish Immunology. 2013, 34(2):546-555.

IF=3.3220 ;
Li Linfang, Wei Shulei, Hunag Qiaoyan, Feng Dong, Zhang Shicui, Liu Zhenhui*, A novel

galanin receptor 1a gene in zebrafish: Tissue distribution, developmental expression

roles in nutrition regulation, Comp. Biochem. Physiol. B, 2013, 164(3):159-167.

IF=1.984
Sun, Yanling, Liu, Zhenhui*, Zhang, Shicui, 2010,Tissue distribution, developmental

expression and up-regulation of p8 transcripts on stress in zebrafish, FISH & SHELLFISH

IMMUNOLOGY, 28(4), pp 549-554, 2010/4.
Liu, Zhenhui*, Li, Lei, Li, Hongyan, Zhang, Shicui, Ji, Guangdong, Sun, Yanling,

2009,EST analysis of the immune-relevant genes in Chinese amphioxus challenged with

lipopolysaccharide, FISH & SHELLFISH IMMUNOLOGY, 26(6), pp 843-849, 2009/6/6.
Liu, Zhenhui*, Sun, Yanling, Liu, Naiguo, Fan, Ningning, Zhang, Shicui,

2009,Characterization, expression, and response to stress of p8 gene in amphioxus, FISH

& SHELLFISH IMMUNOLOGY, 27(3), pp 407-413, 2009/9.
Luan, Jing, Liu, Zhenhui*, Zhang, Shicui, Li, Hongyan, Fan, Chunxin, Li, Lei,

2007,Characterization, evolution and expression of the calmodulin1 genes from the

amphioxus Branchiostoma belcheri tsingtauense, ACTA BIOCHIMICA ET BIOPHYSICA SINICA,

39(4), pp 255-264, 2007/4/4.
Sun, Yanling, Feng, Dong, Huang, Qiaoyan, Zhang, Shicui, Liu, Zhenhui*,

2012,Localization, developmental regulation and stress induction of p8-L1 and p8-L2 in

zebrafish, Central European Journal of Biology, 7(4), pp 626-633, 2012/8.
Liu, ZH, Zhang, SC, Li, HY, Luan, J, Wang, YJ, Wang, L, Xiang, JH,

2005,Characterization and expression profile of AmphiCD63 encoding a novel member of

TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense, DNA SEQUENCE, 16(3),

pp 195-201, 2005/6.
刘宁宁，魏书磊，李林芳, 张敏, 徐艳萍，刘振辉*。鱼类脂味觉的行为学检测。渔业科学进展，

33(6): 23-28. 2012.
Fenech, Claire, Patrikainen, Lila, Kerr, Daniel S., Grall, Sylvie, Liu, Zhenhui,

Laugerette, Fabienne, Malnic, Bettina, Montmayeur, Jean-Pierre*, Ric-8A, a G alpha

protein guanine nucleotide exchange factor potentiates taste receptor signaling,

Frontiers in Cellular Neuroscience, | Volume 3 | Article 11 | 1. doi:

10.3389/neuro.03.011. 2009. IF=4.1710.
Montmayeur, Jean-Pierre, Fenech, Claire, Kusumakshi, Soumya, Laugerette, Fabienne, Liu,

Zhenhui, Wiencis, Anna, Boehm, Ulrich, Screening for G-protein-coupled receptors

expressed in mouse taste papillae, Flavour and Fragrance Journal, 26(4), pp 223-230,

2011. IF=1.4240
Fan, Chunxin, Zhang, Shicui, Liu, Zhenhui, Li, Lei, Luan, Jing, Saren, Gaowa,

2007,Identification and expression of a novel class of glutathione-S-transferase from

amphioxus Branchiostoma belcheri with implications to the origin of vertebrate liver,

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 39(2), pp 450-461, 2007.
Luan, Jing, Zhang, Shicui, Liu, Zhenhui, Fan, Chunxin, Ji, Guangdong, Li, Lei,

2007,Characterization, evolution and tissue-specific expression of AmphiCalbin, a novel

gene encoding EF-hand calcium-binding protein in amphioxus Branchiostoma belcheri, ACTA

BIOCHIMICA ET BIOPHYSICA SINICA, 39(11), pp 891-900, 2007/11.
He, Yanan, Tang, Bo, Zhang, Shicui, Liu, Zhenhui, Zhao, Bosheng, Chen, Linlin,

2008,Molecular and immunochemical demonstration of a novel member of Bf/C2 homolog in

amphioxus Branchiostoma belcheri: Implications for involvement of hepatic cecum in

acute phase response, FISH & SHELLFISH IMMUNOLOGY, 24(6), pp 768-778, 2008/6.
Tian, Jianxiao, Zhang, Shicui, Liu, Zhenhui, Zhuang, Yunyun, Wang, Yongjun, Jiang,

Shengjuan, 2007,Characterization and tissue-specific expression of phosphatidylcholine

transfer protein gene from amphioxus Branchiostoma belcheri, CELL AND TISSUE RESEARCH,

330(1), pp 53-61, 2007/10.
Wang, YJ, Zhang, SC, Liu, ZH, Li, HY, Wang, L, 2005,Characterization and expression of

AmphiCL encoding cathepsin L proteinase from amphioxus Branchiostoma belcheri

tsingtauense, MARINE BIOTECHNOLOGY， 7(4), pp 279-286, 2005/8.
Li, Zhaojie, Zhang, Shicui, Zhang, Jun, Liu, Min, Liu, Zhenhui, 2009,Vitellogenin is a

cidal factor capable of killing bacteria via interaction with lipopolysaccharide and

lipoteichoic acid, MOLECULAR IMMUNOLOGY, 46(16), pp 3232-3239, 2009/10.
Liu, M, Zhang, SC, Liu, ZH, Li, HY, Xu, AL, 2006,Characterization, organization and

expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma

belcheri tsingtauense, GENE, 367卷, pp 110-117, 2006/2/15.
Liu, Naiguo, Zhang, Shicui, Liu, Zhenhui, Gaowa, Saren, Wang, Yongjun,

2007,Characterization and expression of gamma-interferon-inducible lysosomal thiol

reductase (GILT) gene in amphioxus Branchiostoma belcheri with implications for GILT in

innate immune response, MOLECULAR IMMUNOLOGY, 44(10), pp 2631-2637, 2007/4.
Wang, Lei, Zhang, Shicui, Liu, Zhenhui, Li, Hongyan, Wang, Yongjun, Jiang, Shengjuan,

2007,Characterization and expression of amphioxus ApoD gene encoding an archetype of

vertebrate ApoD proteins, CELL BIOLOGY INTERNATIONAL, 31(1), pp 74-81, 2007/1/1.
Zhao, Bosheng, Zhang, Shicui, Wang, Yongjun, Liu, Zhenhui, Kong, Dexin,

2006,Characterization and expression of p23 gene in the amphioxus Branchiostoma

belcheri, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY,

145(1), pp 10-15, 2006/9.
Wang, YJ, Zhang, SC, Liu, ZH, Li, HY, Wang, L, 2005,Identification and expression of

amphioxus beta-microseininoprotein (MSP)-like gene encoding an ancient and rapidly

evolving protein in chordates, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY &

MOLECULAR BIOLOGY, 142(3), pp 251-257, 2005/11.
Wang, YJ, Zhang, SC, Liu, ZH, Li, HY, Wang, L, 2005,Amphioxus allantoicase: Molecular

cloning, expression and enzymatic activity, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-

BIOCHEMISTRY & MOLECULAR BIOLOGY, 141(2), pp 237-243, 2005/6/6.