姓名：张全启

学历/职称/职务：博士/教授

联系方式：

邮箱：qzhang@ouc.edu.c 电话：**

地址：青岛市鱼山路5号

学习工作简历：

1979.9-1983.7：中国海洋大学（原山东海洋学院）海洋生命学院，获理学学士学位。

1983.9-1986.7：中国海洋大学海洋生命学院，获理学硕士学位。

1986.7-1994.2：中国海洋大学海洋生命学院，助教、讲师。

1994.10-1998.2：日本广岛大学生物生产学部，获哲学博士学位。

1998.3-1999.2：美国威廉马丽大学海洋研究所，博士后。

1999.3-2001.2：日本水产养殖研究所，科技厅特别研究员（博士后）。

1999.12—现在：中国海洋大学海洋生命学院教授、博士生导师。其中，

2003.10-2011.7期间，任中国海洋大学海洋生命学院院长。

科研领域描述：

多年来，一直从事海洋生物遗传学和基因组学研究，主要研究内容包括：（1）鱼类分子遗传学及优良品种选育；（2）鱼类染色体组操作与性别决定机制；（3）鱼类基因组学和功能基因研究；（4）鱼类胚胎干细胞、生殖干细胞分离培养、移植及借腹生子研究。

（1）在我国率先建立了星鲽和石鲽的生殖调控人工繁殖技术体系，实现了星鲽和石鲽的人工繁殖，使我国鲽类人工繁殖技术达到国际先进水平。（2）率先开展半滑舌鳎基因组学研究，分析了半滑舌鳎基因组特征；建立了鱼类染色体显微切割技术、性别鉴定技术、性别控制育种技术等，在国内外同领域产生重要影响。（3）开展了牙鲆分子和细胞遗传学研究，建立了牙鲆优良品种培育体系。（4）开展了鲆鲽鱼类胚胎干细胞和生殖干细胞研究，分离鉴定了一批胚胎干细胞和生殖干细胞特异表达的基因，构建了干细胞特异表达的GFP识别载体，并成功地识别了胚胎干细胞和生殖干细胞，为进一步开展鱼类借腹生子研究奠定了基础。（5）近年来承担完成国家级、省部级课题数十项；发表论文80余篇，其中SCI收录60余篇；获专利6项，国家知识产权2项，获省部级奖励4项。



代表性成果：

代表性论文

1. Qiwang Zhong, Quanqi Zhang*, Yanjie Chena, Yeying Suna, Jie Qia, Zhigang Wanga, Shuo Lia, Chunmei Lia and Xun Lan. 2008. The isolation and characterization of myostatin gene in Japanese flounder (Paralichthys olivaceus): Ubiquitous tissue expression and developmental specific regulation. Aquaculture, 281 (1-4): 247-255.

2. Qiwang Zhong, Quanqi Zhang*, Zhigang Wang, Jie Qi, Yanjie Chen, Shuo Li, Yeying Sun, Chunmei Li, Xun Lan, 2008. Expression Profiling and Validation of Potential Reference Genes During Paralichthys olivaceus Embryogenesis. Marine Biotechnology. 10(3): 310-318.

3. Xubo Wang, Quanqi Zhang*, Xiaohua Sun, Yanjie Chen, Teng Zhai, Wei Zhuang, Jie Qi and Zhigang Wang. 2009. Fosmid Library Construction and Initial Analysis of End Sequences in Female Half-smooth Tongue Sole (Cynoglossus semilaevis) Marine Biotechnology, 11(2): 236-242.

4.Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang; Fusheng Yan; Zhigang Wang; Quanqi Zhang*, 2009. Isolation and characterization of Toll-like receptor 9 in half-smooth tongue sole Cynoglossus semilaevis. Fish and Shellfish Immunology. 26：492-499.



5. Jianpeng Xu, Quanqi Zhang*, Xiaofei Xu, Zhigang Wang, Jie Qi. 2009. Intragenomic Variability and Pseudogenes of Ribosomal DNA in Stone Flounder Kareius bicoloratus. Molecular Phylogenetics and Evolution 52 (2009) 157-166.

6. Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang; Fusheng Yan; Zhigang Wang; Quanqi Zhang*, 2009. Full-length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half-smooth tongue sole Cynoglossus semilaevis. International Journal of Immunogenetics. 36: 173–182.

7. Xubo Wang, Quanqi Zhang*, Jian Ren, Zhanjun Jiang, Changmeng Wang, Wei Zhuang, Teng Zhai, 2009. The preparation of sex-chromosome-specific painting probes and construction of sex chromosome DNA library in half-smooth tongue sole (Cynoglossus semilaevis). Aquaculture, 297: 78-84.

8. WANG Xubo, ZHANG Quanqi*, CHEN Yanjie, QI Jie, WANG Zhigang, WANG Xinglian, 2009. Cytogenetic characterization of olive flounder Paralichthys olivaceus: DNA content, karyotype, AgNORs and location of major ribosomal genes. Acta Oceanologica Sinica, 28(4): 72-77.

9. Yeying Sun, Haiyang Yu, Quanqi Zhang*, Jie Qi, Qiwang Zhong, Yanjie Chen, Chunmei Li. 2010. Molecular characterization and expression pattern of two zona pellucida genes in half-smooth tongue sole (Cynoglossus semilaevis). Comparative Biochemistry and Physiology, Part B. 155 (2010) 316–321.

10. Yeying Sun, Quanqi Zhang*, Jie Qi, Yanjie Chen, Qiwang Zhong, Yan Yu, Shuo Li, Zhigang Wang, Chunmei Li. 2010. Identification of differential genes in the ovary relative to the testis and their expression patterns in half-smooth tongue sole (Cynoglossus semilaevis). J. Genet. Genomomics, 37 (2): 137-145.

11. Yuding Fan, Shuo Li, Jie Qi, Lingbing Zeng, Qiwang Zhong, Quanqi Zhang*. 2010. Cloning and characterization of type II Interleukin-1 receptor cDNA from Japanese flounder (Paralichthys olivaceus). Comparative Biochemistry and Physiology, Part B. 157: 59–65.

12. Quanqi Zhang*, Haiyang Yu, Aimee Howe, Whitney Chandler & Standish K. Allen Jr. 2010. Cytogenetic mechanism for reversion of triploids to heteroploid mosaics in Crassostrea gigas (Thunberg) and Crassostrea ariakensis. Aquaculture Research, 41, 1658-1667.

13. Quanqi Zhang*, Yan Zhuang and Standish K. Allen. 2010. Meiotic chromosome configurations in triploid and heteroploid mosaic males of Crassostrea gigas and Crassostrea. ariakensis. Aquaculture Research, 41, 1699-1706.

14. Li, C., Yu, Y., Sun, Y., Li, S., Zhong, Q., Wang, X., Wang, Z., Qi, J., Zhang, Q*. 2010. Isolation, polymorphism and expression study of two distinct major histocompatibility complex class II B genes from half-smooth tongue sole (Cynoglossus semilaevis). Intern. J. Immunogenet. 37(3):185-197.

15. Chunmei Li, Quanqi Zhang*, Yan Yu, Shuo Li, Qiwang Zhong, Yeying Sun, Zhigang Wang, Jie Qi, Jieming Zhai and Xubo Wang. 2011. Sequence polymorphism of two major histocompatibility (MH) class II B genes and their association with Vibrio anguillarum infection in half-smooth tongue sole (Cynoglossus semilaevis). Chinese Journal of Oceanology and Limnology, 29 (6): 1275-1286.

16.Yu H, He Y, Wang X, Zhang Q, Bao Z, Guo X. 2011. Polymorphism in a serine protease inhibitor gene and its association with disease resistance in the eastern oyster (Crassostrea virginica Gmelin). Fish Shellfish Immunol. 30(3): 757-62.

17. Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang, Yanan Wang, Yeying Sun, Xubo Wang, Zhigang Wang, Quanqi Zhang*. 2012. Identification and characterization of IL-1 receptor-associated kinase-4 (IRAK-4) in half-smooth tongue sole Cynoglossus semilaevis. Fish and Shellfish Immunology. 32(4):609-15.

18. He Y, Yu H, Bao Z, Zhang Q, Guo X. 2012. Mutation in promoter region of a serine protease inhibitor confers Perkinsus marinus resistance in the eastern oyster (Crassostrea virginica). Fish Shellfish Immunol. 33(2): 411-7.

19. Wang Xubo, Jiajun Jiang, Jinning Gao, Jinxiang Liu, Jie Qi, Zhigang Wang, Haiyang Yu, Quanqi Zhang, 2013. Identification of two novel female-specific DNA sequences in half-smooth tongue sole, Cynoglossus semilaevis. Aquaculture, 388-391: 49-53.

20. Liming Jiang, Guannan Chu, Quanqi Zhang, Zhigang Wang, Xubo Wang, Jieming Zhai, Haiyang Yu, 2013. A microsatellite genetic linkage map of half smooth tongue sole (Cynoglossus semilaevis). Marine Genomics, 9: 17-23.

21. J. Jiang, C. Li, Q. Zhang, and X. Wang. 2013. Cloning and characterization of major histocompatibility complex class II genes in the stone flounder Kareius bicoloratus (Pleuronectidae). Genetics and Molecular Research. 12 (4): 5820-5832.

22. Ma Liman, Wang Wenji, Liu Conghui, Yu Haiyang, Wang Zhigang, Wang Xubo, Qi Jie, Zhang Quanqi. 2013. Selection of reference genes for reverse transcription quantitative real-time PCR normalization in black rockfish (Sebastes schlegeli). Marine Genomics. 11: 67-73.

23. Jinning Gao, JingWang, Jiajun Jiang, Lin Fan,Wenji Wang, Jinxiang Liu, Quanqi Zhang*, XuboWang. 2013. Identification and characterization of a nanog homolog in Japanese flounder (Paralichthys olivaceus). Gene. 531 (2): 411-421.

24. Xiaomeng Wu, Zhongkai Wang, Jiajun Jiang, Jinning Gao, Jing Wang, Xiaosu Zhou, Quanqi Zhang. 2014. Cloning, expression and promoter analysis of vasa gene in Japanese flounder (Paralichthys olivaceus). Comparative Biochemistry and Physiology, Part B 167: 41-50.

25. ZhengRui Zhang, Xinglian Wang, Quanqi Zhang and Standish K. Allen. Jr. 2014. Cytogenetic mechanisms on the aneuploidy and mosaicism in tetraploid Pacific oysters Crassostrea gigas (Thunberg) produced from eggs of triploids. J. Ocean Univ. China, 13 (1): 125-131.

26. ZhengRui Zhang, Xinglian Wang, Quanqi Zhang and Standish K. Allen. Jr. 2013. Preferential bivalent formation in tetraploid males of Pacific oysters Crassostrea gigas (Thunberg). J. Ocean Univ. China, 13 (2): 297-302.

27. Zhongkai Wang, Jinning Gao, Huayu Song, Xiaomeng Wu, Yan Sun, Jie Qi, Haiyang Yu, Zhigang Wang, Quanqi Zhang. 2014. Sexually dimorphic expression of vasa isoforms in the tongue sole (Cynoglossus semilaevis). PLOS ONE, 9 (3): e93380.

28. Conghui Liu, Nian Xin, Yi Zhai, Liming Jiang, Jieming Zhai, Quanqi Zhang, Jie Qi. 2014. Reference Gene Selection for Quantitative Real-Time RT-PCR Normalization in the Half-Smooth Tongue Sole (Cynoglossus semilaevis) at Different Developmental Stages, in Various Tissue Types and on Exposure to Chemicals. PLOS ONE, 9 (3): e91715.

专利、著作权

1. 王旭波，张全启，齐洁，王志刚，于海洋，**。一种激光纤维切割染色体标本制作液及其应用，ZL 2011 1 **.8

2. 王亚楠，张全启，刘旭东，王旭波，齐洁，于海洋，王兴莲，**。半滑舌鳎hepcidin抗菌肽，ZL 2011 1 **.2

3. 王亚楠，张全启，刘旭东，王旭波，齐洁，于海洋，王兴莲，**。半滑舌鳎抗菌肽hepcidin的重组表达及其应用，ZL 2011 1 **.3

4. 王旭波，张全启，高金宁，姜佳君，齐洁，王志刚，于海洋，**。荧光原位杂交技术检测半滑舌鳎的行染色体组成的方法，ZL 2011 1 **.4

杨俊杰，张全启，2009。鲽型目分类信息分析系统，2009SR02219