胡晓丽 博士，教授，博士生导师

研究方向：贝类分子遗传学




一、学习及工作经历

1989.9－1993.7 青岛海洋大学水产学院食品工程专业，获学士学位

1993.9－2000.8 青岛市农业科学研究所工作

2000.9－2005.6 中国海洋大学海洋生命学院海洋生物学专业，获博士学位

2005.7－至今 中国海洋大学海洋生命学院工作

2009.8－2010.8 美国斯坦福大学生物系访问学者




二、近三年主要科研项目

1. 国家重点基础研究发展规划项目计划（973计划）：贝类分子设计育种的关键技术研究（2010CB126406），2012-2014，主持

2. 国家自然科学基金：引种日本皱纹盘鲍对我国本土种质资源遗传结构影响的研究（**），2012-2015，主持

3. 国家自然科学基金：栉孔扇贝抑肌素myostatin及其信号途径基因的表达调控（**），2010-2012，主持

4. 国家高技术研究发展计划（863计划）重大项目：海洋生物分子细胞育种关键技术（2012AA10A402），2012-2015，第二位

5. 国家重点基础研究发展规划项目计划（973计划）：贝类SNP规模发掘及高密度遗传连锁图谱的构建（2010CB126402），2010-2011，第三位




三、近五年发表论文（*通讯作者）

1. Liying Feng, Xue Li, Qian Yu, Xianhui Ning, Jinzhuang Dou, Jiajun Zou, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao*. A Scallop IGF Binding Protein Gene: Molecular Characterization and Association of Variants with Growth Traits. PLoS ONE. 2014; 9(2): e89039.

2. Wenqian Jiao, Xiaoteng Fu, Jinqin Li, Ling Li, Liying Feng, Jia Lv, Lu Zhang, Xiaojian Wang, Yangping Li, Rui Hou, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Large-scale development of gene-associated single-nucleotide polymorphism markers for molluscan population genomic, comparative genomic, and genome-wide association studies. DNA Research. 2014. 21(2):183-193.

3. Xiaoteng Fu, Yan Sun, Jing Wang, Qiang Xing, Jiajun Zou, R Li, Z Wang, Shi Wang, Xiaoli Hu, Lingling Zhang*, Zhenmin Bao*. Sequencing-based gene network analysis provides a core set of gene resource for understanding thermal adaptation in Zhikong scallop Chlamys farreri. Molecular Ecology Resources. 2014. 14(1): 184–198.

4. Yueyue Zhang, Lingling Zhang, Jin Sun, Jianwen Qiu, Xiaoli Hu, Jingjie Hu, Zhenmin Bao*. Proteomic analysis identifies proteins related to carotenoid accumulation in Yesso scallop (Patinopecten yessoensis). Food Chemistry. 2014. 147: 111-116.

5. Jessica Chang, Yiqi Zhou, Xiaoli Hu, Lucia Lam, Cameron Henry, Erin M. Green, Ryosuke Kita, Michael S. Kobor, Hunter B. Fraser*. The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genetics. 2013. 9(9):e**.

6. Jia Lv, Liying Feng, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Wenqian Jiao, Lingling Zhang, Shi Wang, Yan He*, Xiaoli Hu*. Molecular characterization of RXR (Retinoid X Receptor) gene isoforms from the bivalve species Chlamys farreri. PLoS ONE. 2013. 8(9): e74290.

7. Liying Feng, Qian Yu, Xue Li, Xianhui Ning, Jing Wang, Jiajun Zou, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*, Zhenmin Bao. Identification of reference genes for qRT-PCR analysis in Yesso scallop Patinopecten yessoensis. PLoS ONE. 2013. 8(9): e75609.

8. Yan He, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*. Molecular cloning and characterization of SoxB2 gene from Zhikong scallop Chlamys farreri. Chinese Journal of Oceanology and Limnology. 2013. 31(6):1216-1225.

9. Shan Wang, Rui Hou, Zhenmin Bao, Huixia Du, Yan He, Hailin Su, Yueyue Zhang, Xiaoteng Fu, Wenqian Jiao, Yan Li, Lingling Zhang, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing of Zhikong Scallop (Chlamys farreri) and comparative transcriptomic analysis with Yesso Scallop (Patinopecten yessoensis). PLoS ONE. 2013. 8(5): e63927.

10. Jiqin Li, Zhenmin Bao, Ling Li, Xiaojian Wang, Shi Wang, Xiaoli Hu*. Development of 101 novel EST-derived single nucleotide polymorphism markers for Zhikong scallop, Chlamys farreri. Journal of Ocean University of China. 2013. 12 (3): 403-412.

11. Huihui Guo, Zhenmin Bao, Huixia Du, Lingling Zhang, Shi Wang, Luyang Sun, Xiaoyu Mou, Xiaoli Hu*. Identification of Cytochrome P450 (CYP) Genes in Zhikong Scallop (Chlamys farreri). Journal of Ocean University of China. 2013. 12(1): 97-102.

12. Junxia Mao, Jia Lv, Yan Miao, Changsen Sun, Liping Hu, Ru Zhang, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Development of a rapid and efficient method for non-lethal DNA sampling and genotyping in scallops. PLoS ONE. 2013. 8(7): e68096.

13. Xiaoteng Fu, Jinzhuang Dou, Junxia Mao, Hailin Su, Wenqian Jiao, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Shi Wang*, Zhenmin Bao*. RADtyping: An Integrated Package for Accurate De Novo Codominant and Dominant RAD Genotying in Mapping Populations. PLoS One. 2013. 8(11): e79960.

14. Wenqian Jiao, Xiaoteng Fu, Jinzhuang Dou, Hengde Li, Hailin Su, Junxia Mao, Qian Yu, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Yangfan Wang, Shi Wang*, Zhenmin Bao*. High-resolution linkage and quantitative trait locus mapping aided by genome survey sequencing: Building up an integrative genomic framework for a bivalve mollusc. DNA Research. 2013. Doi: 10.1091/dnares/dst043.

15. Yueyue Zhang, Ru Zhang, Jiajun Zou, Xiaoli Hu, Shi Wang, Lingling Zhang*, Zhenmin Bao*. Identification and characterization of four ferritin subunits involved in immune defense of the Yesso scallop (Patinopecten yessoensis). Fish and Shellfish Immunology. 2013. 34: 1178-1187.

16. 李纪勤, 包振民*, 李玲, 胡晓丽. 栉孔扇贝EST-SNP标记开发及多态性分析. 中国海洋大学学报. 2013. 43(1): 56-63.

17. 窦锦壮, 赵熙强, 付晓腾, 焦文倩, 王南南, 张玲玲, 胡晓丽, 王师*, 包振民. 测序错误和重复序列对无参照基因组单核苷酸多态性分型的影响. 中国海洋大学学报. 2013. 43(5):120-124.

18. 郭慧慧, 包振民, 连珊珊, 贺艳, 胡晓丽*. 栉孔扇贝骨形态发生蛋白I型受体基因的克隆及表达分析. 中国海洋大学学报. 2013. 43(5): 37-43.

19. 吕佳，侯睿，李宁，王宸，张玲玲，胡晓丽，王师，包振民*. 应用MSAP技术研究扇贝全基因组DNA甲基化水平. 中国海洋大学学报. 2013. 43(8): 48-53.

20. 封利颖, 郭慧慧, 李雪, 于茜, 胡晓丽, 张玲玲, 王师, 包振民*. 栉孔扇贝骨形态发生蛋白2基因的克隆及表达分析. 中国海洋大学学报. 2013. 43(12): 48-55.

21. Huihui Guo, Zhenmin Bao, Jiqin Li, Shanshan Lian, Shi Wang, Yan He, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu*. Molecular characterization of TGF-β Type I receptor gene (Tgfbr1) in Chlamys farreri, and the association of allelic variants with growth traits. PLoS ONE. 2012. 7(11): e51005.

22. Xiaojian Wang, Xiaoli Hu, Jiqin Li, Ling Li, Rui Hou, Shi Wang, Lingling Zhang*, Zhenmin Bao. Characterization of 38 EST-derived SNP markers in Zhikong scallop (Chlamys farreri) and their cross-species utility in Yesso scallop (Patinopecten yessoensis). Conservation Genetics Resources. 2012. 4:747–753.

23. Lingling Zhang, Rui Hou, Hailin Su, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Network analysis of Oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock. PLoS ONE. 2012. 7(4): e35484.

24. Qinglei Meng, Zhenmin Bao, Zhaoping Wang, Shi Wang, Jingjie Hu, Xiaoli Hu,Xiaoting Huang*. Growth and reproductive performance of triploid Yesso scallops (Patinopecten yessoensis) induced by hypotonic shock. Journal of Shellfish Research. 2012. 31 (4): 1-10.

25. Jinzhuang Dou, Xiqiang Zhao, Xiaoteng Fu, Wenqian Jiao, Nannan Wang, Lingling Zhang, Xiaoli Hu, Shi Wang, Zhenmin Bao*. Reference-free SNP calling: Improved accuracy by preventing incorrect calls from repetitive genomic regions. Biology Direct. 2012. 7: 17.

26. Huixia Du, Zhenmin Bao, Rui Hou, Shan Wang, Hailin Su, Jingjing Yan, Meilin Tian, Yan Li, Wen Wei, Wei Lu, Xiaoli Hu, Shi Wang*, Jingjie Hu*. Transcriptome sequencing and characterization for the sea cucumber Apostichopus japonicas (Selenka, 1867). PLoS ONE. 2012. 7(3): e33311.

27. Rui Hou, Zhenmin Bao, Shan Wang, Hailin Su, Yan Li, Huixia Du, Jingjie Hu, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing and De Novo analysis for Yesso Scallop (Patinopecten yessoensis) using 454 GS FLX. PLoS ONE. 2011. 6(6): e21560.

28. 包振民*，王明玲，李艳，张玲玲，胡晓丽，黄晓婷，胡景杰，王师. 基于核基因组标记的群体遗传学研究中的数学分析方法. 中国海洋大学学报. 2011. 41(11): 48-56.

29. Xiaoli Hu, Huihui Guo, Yan He, Shan Wang, Lingling Zhang, Shi Wang, Xiaoting Huang, Scott William Roy, Wei Lu, Jingjie Hu*, Zhenmin Bao. Molecular characterization of myostatin gene from Zhikong scallop Chlamys farreri (Jones et Preston 1904). Genes & Genetic Systems. 2010. 85(3): 207-218.

30. Ning Li, Jingjie Hu, Shan Wang, Jie Cheng, Xiaoli Hu, Zhenyu Lu, Zhenjian Lin, Weiming Zhu, Zhenmin Bao*. Isolation and identification of the main carotenoid pigment from the rare orange muscle of the Yesso scallop. Food Chemistry. 2010. 118: 616-619.

31. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Min Hui, Mingling Wang, Wei Peng, Xiaoting Huang , Shi Wang, Wei Lu, Changsen Sun and Zhenmin Bao*. Construction of microsatellite-based linkage maps and identification of size-related quantitative trait loci for Zhikong scallop (Chlamys farreri). Animal Genetics. 2009. 40: 821-831.

32. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Zunchun Zhou, Min Hui, Shi Wang，Wei Peng， Mingling Wang，Zhenmin Bao*. Fine-scale population genetic structure of zhikong scallop (Chlamys farreri): Do local marine currents drive geographical differentiation? Marine Biotechnology. 2009. 11: 223-235.

33. Aibin Zhan, Zhenmin Bao, Xiaoli Hu, Wei Lu, Jingjie Hu. Methods comparison for microsatellite marker development: different isolation methods, different yield efficiency. Journal of Ocean University of China. 2009. 8(2):161-165.

34. 孟庆磊, 黄晓婷, 赵海波, 赵婷, 李宁, 王昭平, 胡晓丽*, 胡景杰, 包振民. 扇贝异源三倍体诱导.中国水产科学. 2009. 16(5): 718-727.

35. 胡景杰, 战爱斌, 胡晓丽, 陆维, 黄晓婷, 包振民*. 几种养殖扇贝微卫星标记的研究进展.水产学报. 2009. 33(2): 348-356.




四、专利

1. 胡晓丽, 包振民, 黄晓婷, 王师, 张玲玲, 陆维, 王扬帆. 一种饵料藻自动培养与投加装置（专利号：**3.6）

2. 黄晓婷, 胡晓丽, 王师, 张玲玲, 孟庆磊, 王珊, 包振民, 胡景杰. 一种栉孔扇贝基因的染色体定位方法（专利号：ZL **5.6）

3. Zhenmin Bao, Shan Wang, Ning Li, Jingjie Hu, Rui Hou, Xiaoliang Ren, Xiaoli Hu, Wei Lu. Breeding Method for Orange-Adductor-Muscle Scallop. (美国专利号：US**B2)

4. 包振民, 王珊, 胡景杰, 胡晓丽, 李纪勤, 侯睿, 付晓腾, 陆维. 一种大规模筛查扇贝SNP的方法（专利号：ZL **3.4）

5. 包振民, 王珊, 吴厚刚, 胡景杰, 李宁, 侯睿, 任晓亮, 胡晓丽, 陆维. 一种橘红色闭壳肌扇贝的培育方法（专利号：ZL **0.0）

6. 包振民, 胡晓丽, 张玲玲, 王师, 郭慧慧, 张月月. 栉孔扇贝TGF-? I型受体基因及其SNP位点（申请号：**1.0）

7. 包振民, 胡晓丽, 张玲玲, 王师, 黄晓婷, 王扬帆, 陆维.一种饵料藻自动培养与投加方法（申请号：**3.9）

8. 包振民, 张月月, 张玲玲, 胡晓丽, 陆维. 虾夷扇贝铁蛋白基因及其应用（申请号：**5.5）




五、奖励及称号

1. 教育部新世纪人才（2009）

2. 国家科技进步二等奖（第6受奖人，2008）

3. 教育部科技进步一等奖（第3受奖人，2007）

4. 青岛市科技进步一等奖（第3受奖人，2007）

5. 中国海洋大学“五四”青年奖（2008）




联系方式

电话：**

邮箱：hxl707@ouc.edu.cn

地址：青岛市鱼山路5号中国海洋大学化学馆224室