庄剑辉 讲师，主治医师
硕士招生类型：学术型
硕士招生专业：内科学（心血管内科）
博士招生类型：无
博士招生专业：无
所在院系：附属第十人民医院
联系方式：jh_zhuang@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

天然免疫与血管重构和动脉粥样硬化的基础研究The mechanism of innate immunity in vascular remodeling and atherosclerosis
同济大学附属第十人民医院 心血管内科 主治医师，讲师；上海市医学会 会员
Attending and Lecturer, Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University；Member of Shanghai Medical Association
熟练掌握心血管常见病和危重症的规范化诊疗。长期从事动脉粥样硬化和血管重构的基础与临床转化研究，目前以第一作者或通讯作者身份在Nature Communications、ATVB、FASEB J、EUROPACE和JAHA等权威杂志发表SCI论文11篇，累积影响因子超过50分；获得2020年东方新星奖和2019年院科技新人，多次在国际专业学术大会，如AHA、ACC和GW-ICC进行大会交流；担任包括ATVB、JAHA、Biomedicine & Pharmacotherapy和European Journal of Internal Medicine。目前承担国家自然科学基金、中央高校基础研究计划、上海市卫健委临床研究专项和院攀登人才浦江人才培育各一项。
以第一作者或通讯作者发表的代表性论著：1. Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J*, Xu Y*, Peng W*. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ. Nat Commun. 2019;10:2882. （IF=12.121）
2. Luan P#, Zhuang J#, Zou J, Li H, Shuai P, Xu X, Zhao Y, Kou W, Ji S, Peng A, Xu Y, Su Q, Jian W* and Peng W*. NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation. FASEB J. 2018;32:1070-1084.（IF=4.966）
3. Zhuang J, Luan P, Li H, Wang K, Zhang P, Xu Y*, Peng W*. The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling. Arteriosclerosis, thrombosis, and vascular biology. 2017;37:84-97.（IF=6.604）
4. Jiang D#, Zhuang J#, Peng W, Lu Y, Liu H, Zhao Q, Chi C, Li X, Zhu G, Xu X, Yan C, Xu Y, Ge J, Pang J*. Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity. J Am Heart Assoc. 2017;6(7). pii: e005537.（IF=4.605）
5. Chen L#, Zhuang J#, Singh S, Wang K, Xiong M, Xu D, Chen W, Pang J, Xu Y, Li X*. XAV939 Inhibits Intima Formation by Decreasing Vascular Smooth Muscle Cell Proliferation and Migration Through Blocking Wnt Signaling. J Cardiovasc Pharmacol. 2016;68(6):414-424.（IF=2.598）
Zhuang is expert in the standardized diagnosis and treatment of common cardiovascular diseases and critical diseases. His research works are focused on the cutting-edge of pathogenesis in vascular remodeling and atherosclerosis. On basis of these findings, he hosts 4 research grants, including National Nature Science Foundation of China, the clinical research project of Shanghai Health Commission, Fundamental Research Funds for the Central Universities and Climbing Program for Pujiang Talents. His representative publications appear in prestigious journals such as Nature Communications, ATVB, JAHA, Europace, FASEB J, etc. He is appointed as a reviewer for ATVB、JAHA、Biomedicine & Pharmacotherapy and European Journal of Internal Medicine.