车文良 主任医师，副教授
硕士招生类型：学术型；专业型
硕士招生专业：内科学（心血管内科）
博士招生类型：专业型
博士招生专业：内科学（心血管内科）
所在院系：附属第十人民医院
联系方式：chewenliang@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

肾动脉狭窄加速性动脉粥样硬化机制
冠脉非阻塞性心肌梗死临床特征、机制及预后研究
基于体视化智能建模理论的多模态心血管影像定量检测与分析研究
Novel mechanism of renal artery stenosis accelerated atherosclerosis
Clinical features, mechanism and prognosis of myocardial infarction with non-obstructive coronary arteries
Quantitative detection and analysis of multimodal cardiovascular images based on intelligent stereo visualization modeling theory
上海市第十人民医院心脏中心CCU组长兼崇明分院心内科主任，中华医学会心血管病学分会第10及11届委员会动脉粥样硬化与冠心病学组委员，中国医疗保健国际交流促进会胸痛分会青年委员，上海市胸痛中心联盟专业委员，中国医师协会心内科分会会员，中国心血管疾病介入诊疗培训项目冠心病介入导师，国家自然科学基金及上海自然科学基金评审专家，上海市住院医师规范化培训结业考试考官。
Attending physician of CCU of Shanghai Tenth People's Hospital, Director of Department of Cardiology of Shanghai Tenth People's Hospital Chongming Branch, Member of Atherosclerosis and Coronary Heart Disease Group of the 10th and 11th Committees of the Cardiovascular Society of the Chinese Medical Association, Young Member of Chest Pain Branch of the International Association for the Promotion of Medical Care, Professional Member of Shanghai Chest Pain Center Alliance, China Member of Cardiology Branch of Medical Association, Instructor of Coronary Intervention in China Cardiovascular Intervention Training Project, Assessment Expert of National Natural Science Foundation of China and Shanghai Natural Science Foundation, Examiner of Shanghai Resident Standardized Training Completion Examination
科研课题：国家自然科学基金面上项目，**，Oncostatin M在肾动脉狭窄加速动脉粥样硬化中的作用及机制研究，2016/01-2019/12，68.4万，在研，主持
上海市卫计委面上项目，，LncRNA TUG1在急性心肌梗死诊断及预后评判中的作用研究，2017/1- 2019/12，10万，在研，主持
同济大学2019年人工智能领域学科交叉重点项，，基于体视化智能建模理论的多模态心血管影像定量检测与分析研究，2019/9- 2021/9，60万，在研，主持
上海市崇明区“可持续发展科技创新行动计划”项目，CKY2017-16，崇明心肌梗死基层胸痛中心救治模式的建立，2017/4-2019/3，3万，在研，主持
上海市崇明区“可持续发展科技创新行动计划”项目，CKY2018-18，崇明区早发急性心肌梗死患者家族性高胆固醇血症患病率及诊疗现状研究，2018/4-2020/3，3万，在研，主持
医院350项目：IVUS/OCT/FFR优化复杂冠脉病变PCI治疗，2017/6-2019/5，3万，在研，主持
医院教学项目：反转课堂模式在MBBS心脏病学教学中的运用评价，2018/1-2019/12, 1万，在研，主持
上海市科委，上海市医学引导项目基金，肾动脉狭窄加速性动脉粥样硬化相关炎性因子及其对心血管不良事件的预测价值，负责人， 124119a6900，10万元，2012.10～2015.10，结题
上海市科委，上海市自然科学基金，microRNA调控Gelsolin参与心梗后心肌重塑的机制研究，负责人，11ZR**，10万元，2011.3～2014.4，结题
同济大学优秀青年人才培养行动计划，心梗后心肌重塑过程中miRNA表达特征，负责人，2009KJ011，，2万元，2009.10～2012.10，结题
上海市第十人民医院，2012院优秀学术骨干培养计划，Oncostatin M在肾动脉狭窄加速性动脉粥样硬化中的作用及机制，负责人，12XSGG103，10万元，2012.7～2014.6，结题
PROJECT：The role and mechanism of Oncostatin M in accelerating atherosclerosis of renal artery stenosis, the National Natural Science Foundation of China, **，from 2016/01 to 2019/12,684,000.
The Role of LncRNA TUG1 in the Diagnosis and Prognosis of Acute Myocardial Infarction, Shanghai Health Planning Commission, 2016 0053, 2017/1-2019/12,100,000
Interdisciplinary Key Item in Artificial Intelligence of Tongji University, , Quantitative Detection and Analysis of Multimodal Cardiovascular Images Based on the Theory of Stereo Visual Intelligent Modeling, 2019/9-2021/9, 600,000,
The project of "Action Plan for Sustainable Development of Science and Technology Innovation" in Chongming District, Shanghai, CKY2017-16, the establishment of the treatment model of Chongming Basic-level Chest Pain Center for Myocardial Infarction, 2017/4-2019/30,000
The project of "Action Plan for Sustainable Development of Science and Technology Innovation" in Chongming District, Shanghai, CKY2018-18, the prevalence and diagnosis of familial hypercholesterolemia in patients with early-onset acute myocardial infarction in Chongming District, 2018/4-2020/30,000
Hospital 350 Project: IVUS/OCT/FFR Optimized PCI Treatment for Complex Coronary Diseases, 2017/6-2019/50,000
Hospital Teaching Projects: Evaluation of the Application of Reverse Classroom Model in MBBS Cardiology Teaching, 2018/1-2019/12,10,000
Shanghai Science Committee, Shanghai Medical Guidance Project Fund, Inflammatory Factors Related to Accelerated Atherosclerosis of Renal Artery Stenosis and Their Predictive Value for Cardiovascular Adverse Events, Head, 124119a6900, 100,000 yuan, 2012.10-2015.10
Shanghai Science and Technology Commission, Shanghai Natural Science Foundation, microRNA regulates Gelsolin's involvement in the mechanism of myocardial remodeling after myocardial infarction. Head, 11ZR**, 100,000 yuan, March 2011-April 2014.
Tongji University Outstanding Youth Talents Training Action Plan, Characteristics of MicroRNAs Expression in Myocardial Remodeling after Myocardial Infarction, Director, 2009 KJ011, , 20,000 yuan, 2009.10-2012.10
The role and mechanism of Oncostatin M in accelerating atherosclerosis of renal artery stenosis, responsible person, 12XSGG103,100,000 yuan, 2012.7-2014.6
发表文章[1]Abdu FA, Liu L, Mohammed AQ, Luo Y, Xu S, Auckle R, Xu Y, Che WL*. Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients:Clinical features, treatment and 1?year follow-up. Int J Cardiol. 2019 Jul 15;287:27-31. (通讯，IF:3.471)
[2]Liu L, Zhao D, Zhang J, Yang H, Abdu FA, Guo R, Li S, Tang K, Li H, Che W*, Xu Y. Impact of Stable Coronary Artery Disease on the Efficacy of Cryoballoon Ablation for the Atrial Fibrillation. Am J Med Sci. 2019 Jun 21. pii:S0002-9629(19)30254-X. doi: 10.1016/j.amjms.2019.06.004. (通讯，IF:1.962)
[3]Xu GW, Shen XA, Chen SR, Zong YS, Zhang CY, Yue HY, Liu M, Chen F, Che WL*. A Deep Transfer Convolutional Neural Network Framework for EEG Signal Classification. IEEE Access. 2019;Accepted.(通讯，IF:4.098)
[4]Lan YS, Zhou YH, Lu YW, Wang H, Liu Q, NG E.Y.K., Peng YH, Hao YT, Liu QY, Chen F, Chen Y, Che WL*. A Nine Months Follow-up Study of Hemodynamic Effect on Bioabsorbable Coronary Stent Implantation. IEEE Access. 2019;Accepted.(通讯，IF:4.098)
[5]Lan YS, Ding YM, Luo X, Zhang YZ, Huang CX, Huang WH, Zhou XZ, Su J, Peng YQ, Wang ZC, Cheng YQ, Che WL*. A Clustering based Transfer Function for Volume Rendering Using Gray-Gradient Mode Histogram. IEEE Access. 2019;7:80737-80747.(通讯，IF:4.098)
[6]Jiang S, Guo C, Zhang W, Che W, Zhang J, Zhuang S, Wang Y, Zhang Y, Liu B. The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation. Front Genet. 2019 Jun 13;10:526. doi: 10.3389/fgene.2019.00526. (共同第一，IF:3.517)
[7]Huang C, Tian G, Lan Y, Peng Y, Ng EYK, Hao Y, Cheng Y, Che WL*. A New Pulse Coupled Neural Network (PCNN) for Brain Medical Image Fusion Empowered by Shuffled Frog Leaping Algorithm. Front Neurosci. 2019 Mar 20;13:210. doi: 10.3389/fnins.2019.00210. (通讯，IF:3.648)
[8]Mohammed AQ, Auckle R, Li HL, Xu SL, Liu L, Zhao DD, Che WL*. Pegylated Interferon-α Plus Ribavirin Therapy Improves Left Ventricular Diastolic Dysfunction in Patients With Chronic Hepatitis C Attaining Sustained Virological Response. Am J Med Sci. 2018;355(6):566-572. (通讯，IF: 1.962)
[9] Auckle R, Su B, Li H, Xu S, Xie M, Song Y, Abdul Quddus M, Xu Y, Liu B, Che WL*. Familial hypercholesterolemia in Chinese patients with premature ST-segment-elevation myocardial infarction: Prevalence, lipid management and 1-year follow-up. PLoS One. 2017;12(10):e**. (通讯，IF: 2.766)
[10]Auckle R, Xu SL, Li HL, Mohammed AQ, Xie M, Su B, Liu B, Che WL*. Association of matrix-metalloproteinase-9 with left ventricular diastolic dysfunction in patients with hepatitis C virus infection.Int J Clin Exp Med. 2018; 11( 2): 989-995. (通讯，IF: 0.181)
[11]Huang C, Shan X, Lan Y, Liu L, Cai H, Che WL*, Hao Y, Cheng Y, Peng Y*. A Hybrid Active Contour Segmentation Method for Myocardial D-SPECT Images. IEEE Access. 2018; 6(1): 39334-39343. (共同通讯，IF: 4.098)
[12]Che WL, Liu WL, Wei YD, Xu YW, Hou L, Matsumori A, Hu DY*. Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection. Journal of Viral Hepatitis. 2012; 19(5): 327-331. (第一，IF: 4.088)
[13]Che WL, Zhang BC, Liu WL, Wei YD, Xu YW*, Hu DY*. Association between high-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in Patients with Hepatitis C Virus Infection. Mediators of Inflammation. 2012;2012:730923. doi: 10.1155/2012/730923. (第一，IF: 3.263)
[14] Che WL*, Liu B, Nie F, Wei Y, Li W, Chen W, Xu Y*. Association of TNF-α with leftventricular diastolic dysfunction in patients with hepatitis C virus infection. Int J Cardiol. 20133;168(3):2903-2904.. (第一，IF: 5.509)
[15] Liu B, Che WL(co-first author), Xue JS, Zheng CZ, Tang K, Zhang JY, Wen J, Xu YW*. SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2. Cardiomyoblast Cells. Cellular Physiology and Biochemistry. 2013;32(3):655-662. (共一，IF: 3.415)
[16] Liu B, Che WL(co-first author), Yan HW, Zhu WD, Wang HB*. Effects of Rosuvastatin vs. Simvastatin/ ezetimibe on Arterial Wall Stiffness in Patients with Coronary Artery Disease. Internal medicine. 2013;52(24):2715-2719. (共一，IF: 0.94)
[17] Liu B, Che WL(co-first author), Zheng C, et al. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2013;32(4):1050-1059. (共一，IF: 3.415)
[18]刘露，弗瓦德，印国庆，徐斌，骆艳茹，徐思玲，吕贤，车文良*. 冠状动脉非阻塞性心肌梗死（MINOCA）患者的一年预后及预后影响因素分析[J].国际心血管病杂志,2019, 录用. (通讯)
[19]苏斌杰,郭长峰,李海玲,徐思玲,刘露,徐亚伟, 车文良*.冠状动脉非阻塞性心肌梗死患者的临床特征、治疗现状及院内预后分析[J].国际心血管病杂志,2019,46(01):47-51. (通讯)
[20]李昊，苏斌杰，任莎卡，谢木金，李海玲，徐思玲，车文良*.非心脏科住院患者急性ST段抬高型心肌梗死诊疗现状分析[J].国际心血管病杂志,2018,45(2):89-93. (通讯)
[21]谢木金，任莎卡，刘露，李海玲，徐思玲，车文良*.基线血Oncostatin M水平对肾动脉狭窄患者新发心血管事件的预测价值[J].中国医药导刊,2017,19(11):1086-1089. (通讯)
[22]严叶香，车文良*.院前脉压对STEMI患者MACE发生率及心肌功能血清指标的影响[J].热带医学杂志,2017,17(10):1335-1339. (通讯)